Exploration of Cultivating Business English Talents of Maritime University—Taking Zhejiang Ocean University as an Example

With the construction of Zhoushan Free Trade Zone and settlement of Boeing project, internationalization has brought new opportunities to Zhoushan's foreign trade industries, vigorously promoted Zhoushan's marine economy into rapid development, and put forward higher request to the cultivation of Business English talents. But based on the current social reality, there exist few international Business English talents who both have the ability of language and operation. Zhoushan's marine industries' development is entering a new era of internationalization. If we can cultivate Business English talents who both have the ability of language and operation, we will be sure to break through the bottleneck of Zhoushan's marine industries towards the world. Based on current situation of Business English talents training, this thesis takes Zhejiang Ocean University as an example to make positive contribution to exploring innovative talents training modes of Business English major in maritime universities and promoting the development of Zhoushan's marine economy. This thesis can be divided into 3 parts. Part 1 introduces the background, significance and current situation on cultivating Business English talents of maritime universities. Part 2 is an experimental research on current situation of cultivating Business English talents in Zhejiang Ocean University. And some suggestions on cultivating Business English talents of maritime universities are mentioned in part 3

A mechanism analysis of transverse weld cracks of marine thick steel plate

U postupku zavarivanja omotača za offshore platforme, često dolazi do poprečnih lomova zavara, čak i kada su tehnike zavarivanja, materijali za zavarivanje i brodski čelični limovi pomno odabirani. Sada, međutim, postoji mali broj istraživanja i analiza uzroka takvih oštećenja. U svrhu cjelovite analize uzroka poprečnih lomova zavara brodskog debelog čeličnog lima, ovo istraživanje koristi instrumente kao što su metaloskop, skenirajući elektronski mikroskop (SEM), energo disperzivni spektrometar (EDS) i auger elektronički spektrometar (AES). Zaključak je istraživača da su poprečni lomovi zavara lomovi zbog topline zavarivanja.In the welding process of jackets for offshore platform, transverse weld cracks occur frequently, even when welding techniques, welding materials and marine steel plates used are stringently selected. But now defect failure analysis and mechanism study on this issue are scarce. To fully study the causes of transverse weld cracks of marine thick steel plate, this research uses instruments including metalloscope, scanning electron microscope (SEM), Energy Dispersive Spectrometer (EDS) and Auger Electronic Spectrom (AES). Researchers conclude that transverse weld cracks are welding hot cracks

The nucleus accumbens functional connectivity in patients with insomnia using resting-state fMRI

BackgroundThe aim of this study was to investigate the functional abnormalities between the nucleus accumbens (NAc) and the whole brain in individuals with Insomnia Disorder (ID) using resting-state functional magnetic resonance imaging (fMRI). Additionally, the study aimed to explore the underlying neural mechanisms of ID.MethodsWe enrolled 18 participants with ID and 16 normal controls (NC). Resting-state functional connectivity (FC) between the NAc and the whole brain voxels was calculated and compared between the two groups to identify differential brain region. Receiver operating characteristic (ROC) curve analysis was employed to assess the ability of differential features to distinguish between groups. Furthermore, Pearson correlation analysis was performed to examine the relationship between neurocognitive scores and differential features.ResultsThe ID group exhibited significantly reduced FC values in several brain regions, including the right supplementary motor area, the bilateral middle frontal gyrus, the bilateral median cingulate and paracingulate gyri and the left precuneus. The area under the curve (AUC) of the classification model based on FC in these brain regions was 83.3%. Additionally, the abnormal functional changes observed in ID patients were positively correlated with the Fatigue Severity Scale (R = 0.650, p = 0.004).ConclusionThese findings suggest that the NAc may play a crucial role in the diagnosis of ID and could serve as a potential imaging biomarker, providing insights into the underlying neural mechanisms of the disorder

Profiling analysis of long non-coding RNAs in early postnatal mouse hearts

Mammalian cardiomyocytes undergo a critical hyperplastic-to-hypertrophic growth transition at early postnatal age, which is important in establishing normal physiological function of postnatal hearts. In the current study, we intended to explore the role of long non-coding (lnc) RNAs in this transitional stage. We analyzed lncRNA expression profiles in mouse hearts at postnatal day (P) 1, P7 and P28 via microarray. We identified 1,146 differentially expressed lncRNAs with more than 2.0-fold change when compared the expression profiles of P1 to P7, P1 to P28, and P7 to P28. The neighboring genes of these differentially expressed lncRNAs were mainly involved in DNA replication-associated biological processes. We were particularly interested in one novel cardiac-enriched lncRNA, ENSMUST00000117266, whose expression was dramatically down-regulated from P1 to P28 and was also sensitive to hypoxia, paraquat, and myocardial infarction. Knockdown ENSMUST00000117266 led to a significant increase of neonatal mouse cardiomyocytes in G0/G1 phase and reduction in G2/M phase, suggesting that ENSMUST00000117266 is involved in regulating cardiomyocyte proliferative activity and is likely associated with hyperplastic-to-hypertrophic growth transition. In conclusion, our data have identified a large group of lncRNAs presented in the early postnatal mouse heart. Some of these lncRNAs may have important functions in cardiac hyperplastic-to-hypertrophic growth transition

Oncogenic state and cell identity combinatorially dictate the susceptibility of cells within glioma development hierarchy to IGF1R targeting

Glioblastoma is the most malignant cancer in the brain and currently incurable. It is urgent to identify effective targets for this lethal disease. Inhibition of such targets should suppress the growth of cancer cells and, ideally also precancerous cells for early prevention, but minimally affect their normal counterparts. Using genetic mouse models with neural stem cells (NSCs) or oligodendrocyte precursor cells (OPCs) as the cells‐of‐origin/mutation, it is shown that the susceptibility of cells within the development hierarchy of glioma to the knockout of insulin‐like growth factor I receptor (IGF1R) is determined not only by their oncogenic states, but also by their cell identities/states. Knockout of IGF1R selectively disrupts the growth of mutant and transformed, but not normal OPCs, or NSCs. The desirable outcome of IGF1R knockout on cell growth requires the mutant cells to commit to the OPC identity regardless of its development hierarchical status. At the molecular level, oncogenic mutations reprogram the cellular network of OPCs and force them to depend more on IGF1R for their growth. A new‐generation brain‐penetrable, orally available IGF1R inhibitor harnessing tumor OPCs in the brain is also developed. The findings reveal the cellular window of IGF1R targeting and establish IGF1R as an effective target for the prevention and treatment of glioblastoma

Potential health benefits of lowering gas production and bifidogenic effect of the blends of polydextrose with inulin in a human gut model

Polydextrose is a nutrient supplement, which is widely applied in the food industry. The use of polydextrose in combination with prebiotics and probiotics has recently increased, whereas the fermentation properties of its blend have not yet been fully revealed. We evaluated the metabolic profile of polydextrose, inulin, and their blends by a batch in vitro fermentation of fifteen human fecal inocula. After 24 h of fermentation, polydextrose increased the production of gas, ammonia, and several short chain fatty acids, including propionate and butyrate, when compared to its blends, inulin, and fructo-oligosaccharides. Furthermore, polydextrose had the slowest degradation rate of all the carbohydrates tested, consistent with its partial fermentation in the distal colon. The 16S rRNA gene sequencing analysis of the gut microbiome exhibited significantly increased relative abundance of Clostridium_XVIII, Megamonas, Mitsuokella, and Erysipelotrichaceae_incertae_sedis in polydextrose compared to other carbohydrates. On the other hand, the blends of polydextrose and inulin (1:1 or 2:1) showed reduced gas production and similar bifidogenicity to inulin alone. The blends not only had similar alpha-diversity and PCoA to inulin but also had a similar abundance of beneficial bacteria, such as Faecalibacterium and Roseburia, suggesting potential health benefits. Also their low gas production was likely due to the abundance of Faecalibacterium and Anaerostipes, which were negatively correlated with gas production. Additionally, our in vitro fermentation model shows advantages in the large-scale assessment of fermentation performance

Genome-Wide Association Study for Adult-Plant Resistance to Stripe Rust in Chinese Wheat Landraces (Triticum aestivum L.) From the Yellow and Huai River Valleys

Stripe rust (also known as yellow rust), caused by the pathogen Puccinia striiformis f. sp. tritici (Pst), is a common and serious fungal disease of wheat (Triticum aestivum L.) worldwide. To identify effective stripe rust resistance loci, a genome-wide association study was performed using 152 wheat landraces from the Yellow and Huai River Valleys in China based on Diversity Arrays Technology and simple sequence repeat markers. Phenotypic evaluation of the degree of resistance to stripe rust at the adult-plant stage under field conditions was carried out in five environments. In total, 19 accessions displayed stable, high degrees of resistance to stripe rust development when exposed to mixed races of Pst at the adult-plant stage in multi-environment field assessments. A marker–trait association analysis indicated that 51 loci were significantly associated with adult-plant resistance to stripe rust. These loci included 40 quantitative trait loci (QTL) regions for adult-plant resistance. Twenty identified resistance QTL were linked closely to previously reported yellow rust resistance genes or QTL regions, which were distributed across chromosomes 1B, 1D, 2A, 2B, 3A, 3B, 4A, 4B, 5B, 6B, 7A, 7B, and 7D. Six multi-trait QTL were detected on chromosomes 1B, 1D, 2B, 3A, 3B, and 7D. Twenty QTL were mapped to chromosomes 1D, 2A, 2D, 4B, 5B, 6A, 6B, 6D, 7A, 7B, and 7D, distant from previously identified yellow rust resistance genes. Consequently, these QTL are potentially novel loci for stripe rust resistance. Among the 20 potentially novel QTL, five (QDS.sicau-2A, QIT.sicau-4B, QDS.sicau-4B.2, QDS.sicau-6A.3, and QYr.sicau-7D) were associated with field responses at the adult-plant stage in at least two environments, and may have large effects on stripe rust resistance. The novel effective QTL for adult-plant resistance to stripe rust will improve understanding of the genetic mechanisms that control the spread of stripe rust, and will aid in the molecular marker-assisted selection-based breeding of wheat for stripe rust resistance

What is epistemic peer disagreement, and how should we deal with it?

This paper provides a general overview on the topic of epistemic peer disagreements. It is broadly structured into three sections. In the first section, I provide an introduction to epistemic peer disagreement; I explain what it is, why it is philosophically interesting and introduce the two main contrasting views on how to handle it. In the second section, I provide two arguments on how I think we should manage cases of epistemic peer disagreements. The first argument claims all unverifiable disagreements should be treated with the equal weight view; the second argument claims we should strive to adopt steadfast attitudes towards verifiable disagreements. In the last section, I briefly consider the question of whether epistemic peers even exist, before concluding that they do. Through this paper, I hope to provide a broad overview on how to manage epistemic peer disagreements. I also hope to show that while it is still a relatively new area of epistemology, epistemic peer disagreements are philosophically interesting and should deserve more development and expansion in the future.Bachelor of Arts in Philosoph

Synthesis of some new biflavonoids. (V). Total synthesis of O-hexamethyl brackenin

Oxidative coupling of 2',4',4-trimethoxydihydrochalcone in DMF in the presence of lithium diisopropylamide and CuCl gave 17% the title compd. (I). [on SciFinder (R)

A Decision Method for Autonomous Maneuver in Close Range Air Combat Based on Matrix Game Theory

Aiming at the decision-making problem of UCAV autonomous maneuvering in close range one-to-one scenarios, a close range UCAV autonomous maneuvering decision-making algorithm based on expert know-ledge base and matrix game method is proposed, which can conduct real-time situational analysis and maneuver decision-making in one-to-one close range air combat to achieve victory. This algorithm constructs the launching mechanism of UCAV autonomous air combat based on tactical library, builds the dynamics model of fighter and missile, and builds the situation evaluation function based on typical air combat factors and missile attack area analysis. Further combining the situation evaluation function based on missile attack area with matrix game theory, a set of autonomous air combat decision model is constructed. On this basis, the algorithm is used for game confrontation simulation on both sides of UCAV in typical scenarios. Multiple sets of simulation results showed that the algorithm can effectively conduct real-time maneuvering decision-making game confrontation, and the single step decision-making time of a single machine can be maintained within 80 ms