724 research outputs found
Blockade of CXCL12/CXCR4 signaling inhibits intrahepatic cholangiocarcinoma progression and metastasis via inactivation of canonical Wnt pathway
Common-mode insertion indices compensation with capacitor voltages feedforward to suppress circulating current of MMCs
Interference between distinguishable photons
Two-photon interference (TPI) lies at the heart of photonic quantum
technologies. TPI is generally regarded as quantum interference stemming from
the indistinguishability of identical photons, hence a common intuition
prevails that TPI would disappear if photons are distinguishable. Here we
disprove this perspective and uncover the essence of TPI. We report the first
demonstration of TPI between distinguishable photons with their frequency
separation up to times larger than their linewidths. We perform
time-resolved TPI between an independent laser and single photons with
ultralong coherence time (s). We observe a maximum TPI visibility of
well above the classical limit indicating the quantum
feature, and simultaneously a broad visibility background and a classical beat
visibility of less than reflecting the classical feature. These
visibilities are independent of the photon frequency separation and show no
difference between distinguishable and indistinguishable photons. Based on a
general wave superposition model, we derive the cross-correlation functions
which fully reproduce and explain the experiments. Our results reveal that TPI
as the fourth-order interference arises from the second-order interference of
two photons within the mutual coherence time and TPI is not linked to the
photon indistinguishability. This work provides new insights into the nature of
TPI with great implications in both quantum optics and photonic quantum
technologies.Comment: 7 pages, 5 figures. Comments are welcome. arXiv admin note:
substantial text overlap with arXiv:2404.0515
Quantum and Classical Two-photon Interference of Single Photons with Ultralong Coherence Time
Two-photon interference (TPI) is a fundamental phenomenon in quantum optics
and plays a crucial role in quantum information science and technology. TPI is
commonly considered as quantum interference with an upper bound of for
both the TPI visibility and the beat visibility in contrast to its classical
counterpart with a maximum visibility of . However, this is not always
the case. Here we report a simultaneous observation of quantum and classical
TPI of single photons with ultralong coherence time which is longer than the
photon correlation time by five orders of magnitude. We observe a TPI
visibility of but a beat visibility of . Besides an
anti-bunching central dip due to single-photon statistics, we observe two
bunching side peaks in cross-correlation curves for indistinguishable photons.
Using either classical wave superposition theory or quantum field approach, we
derive the same expressions for the cross-correlation functions which reproduce
and explain the experiments well. We conclude that quantum TPI with a stream of
single photons is equivalent to classical TPI, both of which are the
fourth-order interference arising from the second-order interference occurring
on the time scale of photon coherence time.Comment: 7 pages, 4 figures, Comments are welcom
The VEP Booster: A Closed-Loop AI System for Visual EEG Biomarker Auto-generation
Effective visual brain-machine interfaces (BMI) is based on reliable and
stable EEG biomarkers. However, traditional adaptive filter-based approaches
may suffer from individual variations in EEG signals, while deep neural
network-based approaches may be hindered by the non-stationarity of EEG signals
caused by biomarker attenuation and background oscillations. To address these
challenges, we propose the Visual Evoked Potential Booster (VEP Booster), a
novel closed-loop AI framework that generates reliable and stable EEG
biomarkers under visual stimulation protocols. Our system leverages an image
generator to refine stimulus images based on real-time feedback from human EEG
signals, generating visual stimuli tailored to the preferences of primary
visual cortex (V1) neurons and enabling effective targeting of neurons most
responsive to stimuli. We validated our approach by implementing a system and
employing steady-state visual evoked potential (SSVEP) visual protocols in five
human subjects. Our results show significant enhancements in the reliability
and utility of EEG biomarkers for all individuals, with the largest improvement
in SSVEP response being 105%, the smallest being 28%, and the average increase
being 76.5%. These promising results have implications for both clinical and
technological applicationsComment: 19 pages, 6 figure
Corrigendum: Causal association of gastroesophageal reflux disease with obstructive sleep apnea and sleep-related phenotypes: a bidirectional two-sample Mendelian randomization study
Causal association of gastroesophageal reflux disease with obstructive sleep apnea and sleep-related phenotypes: a bidirectional two-sample Mendelian randomization study
BackgroundThe interactions and associations between obstructive sleep apnea (OSA), sleep-related phenotypes (SRPs), and gastroesophageal reflux disease (GERD) are complex, thus it is hard to explore the effect and direction of causalities.Study objectivesA bidirectional Mendelian randomization (MR) study was performed to explore causal associations of GERD with OSA and SRPs (including insomnia, morningness, sleep duration, ease of getting up, daytime napping, daytime dozing, and snoring).MethodsFirst, we gathered summary statistics from publicly available databases. Subsequently, we identified single-nucleotide polymorphisms without strong linkage (r2 ≤ 0.001) by referencing relevant genome-wide association studies that met genome-wide significance criteria. Our primary analysis relied on inverse variance weighted to estimate the causal relationship. To ensure the validity of our findings, we also conducted several sensitivity analyses. These included MR Pleiotropy RESidual Sum and Outlier to detect and correct for potential pleiotropic effects, MR-Egger to assess directional pleiotropy, and weighted median analysis to further evaluate heterogeneity and pleiotropy. For the initial MR analysis, when causality was indicated by the results, instrumental variables that were significantly linked to the aforementioned confounding factors were removed. We will re-analyze the data after excluding outcome-related single nucleotide polymorphisms to confirm that the results are still consistent with the previous results.ResultsGERD was found to increase the risk of OSA (OR = 1.53, 95% CI = 1.37–1.70, p = 5.3 × 10−15), insomnia (OR = 1.14, 95% CI = 1.10–1.19, p = 1.3 × 10−10), snoring (OR = 1.09, 95% CI = 1.04–1.13, p = 6.3 × 10−5) and less sleep duration (OR = 0.94, 95% CI = 0.91–0.97, p = 3.7 × 10−4). According to the reverse-direction analysis, there is an elevated risk of GERD associated with OSA (OR = 1.07, 95% CI = 1.02–1.12, p = 0.005), insomnia (OR = 1.95, 95% CI = 1.60–2.37, p = 1.92 × 10−11) and snoring (OR = 1.74, 95% CI = 1.37–2.21, p = 4.4 × 10−6).ConclusionGenetic susceptibility to GERD can elevate the likelihood of experiencing insomnia, snoring, and OSA, in addition to diminishing sleep duration. Conversely, a reverse MR analysis indicates that ameliorating any one of insomnia, snoring, or OSA can mitigate the risk of developing GERD
Three-dimensional Pentagon Carbon with a genesis of emergent fermions
Carbon, the basic building block of our universe, enjoys a vast number of
allotropic structures. Owing to its bonding characteristic, most carbon
allotropes possess the motif of hexagonal rings. Here, with first-principles
calculations, we discover a new metastable three-dimensional carbon allotrope
entirely composed of pentagon rings. The unique structure of this "Pentagon
Carbon" leads to extraordinary electronic properties, making it a cornucopia of
emergent topological fermions. Under lattice strain, Pentagon Carbon exhibits
topological phase transitions, generating a series of novel quasiparticles,
from isospin-1 triplet fermions, to triply-degenerate fermions, and further to
concatenated Weyl-loop fermions. Its Landau level spectrum also exhibits
distinct features, including a huge number of almost degenerate chiral Landau
bands, implying pronounced magneto-transport signals. Our work not only
discovers a remarkable carbon allotrope with highly rare structural motifs, it
also reveals a fascinating hierarchical particle genesis with novel topological
fermions beyond the Dirac and Weyl paradigm
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