Design and realization of precise indoor localization mechanism for Wi-Fi devices

Despite the abundant literature in the field, there is still the need to find a time-efficient, highly accurate, easy to deploy and robust localization algorithm for real use. The algorithm only involves minimal human intervention. We propose an enhanced Received Signal Strength Indicator (RSSI) based positioning algorithm for Wi-Fi capable devices, called the Dynamic Weighted Evolution for Location Tracking (DWELT). Due to the multiple phenomena affecting the propagation of radio signals, RSSI measurements show fluctuations that hinder the utilization of straightforward positioning mechanisms from widely known propagation loss models. Instead, DWELT uses data processing of raw RSSI values and applies a weighted posterior-probabilistic evolution for quick convergence of localization and tracking. In this paper, we present the first implementation of DWELT, intended for 1D location (applicable to tunnels or corridors), and the first step towards a more generic implementation. Simulations and experiments show an accuracy of 1m in more than 81% of the cases, and less than 2m in the 95%.Peer ReviewedPostprint (published version

The TGFβ type I receptor TGFβRI functions as an inhibitor of BMP signaling in cartilage.

The type I TGFβ receptor TGFβRI (encoded by Tgfbr1) was ablated in cartilage. The resulting Tgfbr1 Col2 mice exhibited lethal chondrodysplasia. Similar defects were not seen in mice lacking the type II TGFβ receptor or SMADs 2 and 3, the intracellular mediators of canonical TGFβ signaling. However, we detected elevated BMP activity in Tgfbr1 Col2 mice. As previous studies showed that TGFβRI can physically interact with ACVRL1, a type I BMP receptor, we generated cartilage-specific Acvrl1 (Acvrl1 Col2 ) and Acvrl1/Tgfbr1 (Acvrl1/Tgfbr1 Col2 ) knockouts. Loss of ACVRL1 alone had no effect, but Acvrl1/Tgfbr1 Col2 mice exhibited a striking reversal of the chondrodysplasia seen in Tgfbr1 Col2 mice. Loss of TGFβRI led to a redistribution of the type II receptor ACTRIIB into ACVRL1/ACTRIIB complexes, which have high affinity for BMP9. Although BMP9 is not produced in cartilage, we detected BMP9 in the growth plate, most likely derived from the circulation. These findings demonstrate that the major function of TGFβRI in cartilage is not to transduce TGFβ signaling, but rather to antagonize BMP signaling mediated by ACVRL1

Health of Philippine Emigrants Study (HoPES): study design and rationale.

BackgroundImmigrants to the United States are usually healthier than their U.S.-born counterparts, yet the health of immigrants declines with duration of stay in the U.S. This pattern is often seen for numerous health problems such as obesity, and is usually attributed to acculturation (the adoption of "American" behaviors and norms). However, an alternative explanation is secular trends, given that rates of obesity have been rising globally. Few studies of immigrants are designed to distinguish the effects of acculturation versus secular trends, in part because most studies of immigrants are cross-sectional, lack baseline data prior to migration, and do not have a comparison group of non-migrants in the country of origin. This paper describes the Health of Philippine Emigrants Study (HoPES), a study designed to address many of these limitations.MethodsHoPES is a dual-cohort, longitudinal, transnational study. The first cohort consisted of Filipinos migrating to the United States (n = 832). The second cohort consisted of non-migrant Filipinos who planned to remain in the Philippines (n = 805). Baseline data were collected from both cohorts in 2017 in the Philippines, with follow-up data collection planned over 3 years in either the U.S. for the migrant cohort or the Philippines for the non-migrant cohort. At baseline, interviewers administered semi-structured questionnaires that assessed demographic characteristics, diet, physical activity, stress, and immigration experiences. Interviewers also measured weight, height, waist and hip circumferences, blood pressure, and collected dried blood spot samples.DiscussionMigrants enrolled in the study appear to be representative of recent Filipino migrants to the U.S. Additionally, migrant and non-migrant study participants are comparable on several characteristics that we attempted to balance at baseline, including age, gender, and education. HoPES is a unique study that approximates a natural experiment from which to study the effects of immigration on obesity and other health problems. A number of innovative methodological strategies were pursued to expand the boundaries of current immigrant health research. Key to accomplishing this research was investment in building collaborative relationships with stakeholders across the U.S. and the Philippines with shared interest in the health of migrants

Prospects for measuring supermassive black hole masses with future extremely large telescopes

The next generation of giant-segmented mirror telescopes ($>$ 20 m) will enable us to observe galactic nuclei at much higher angular resolution and sensitivity than ever before. These capabilities will introduce a revolutionary shift in our understanding of the origin and evolution of supermassive black holes by enabling more precise black hole mass measurements in a mass range that is unreachable today. We present simulations and predictions of the observations of nuclei that will be made with the Thirty Meter Telescope (TMT) and the adaptive optics assisted integral-field spectrograph IRIS, which is capable of diffraction-limited spectroscopy from $Z$ band (0.9 $\mu$m) to $K$ band (2.2 $\mu$m). These simulations, for the first time, use realistic values for the sky, telescope, adaptive optics system, and instrument, to determine the expected signal-to-noise ratio of a range of possible targets spanning intermediate mass black holes of $\sim10^4$ \msun to the most massive black holes known today of $>10^{10}$ $M_\odot$. We find that IRIS will be able to observe Milky Way-mass black holes out the distance of the Virgo cluster, and will allow us to observe many more brightest cluster galaxies where the most massive black holes are thought to reside. We also evaluate how well the kinematic moments of the velocity distributions can be constrained at the different spectral resolutions and plate scales designed for IRIS. We find that a spectral resolution of $\sim8000$ will be necessary to measure the masses of intermediate mass black holes. By simulating the observations of galaxies found in SDSS DR7, we find that over $10^5$ massive black holes will be observable at distances between $0.005 < z < 0.18$ with the estimated sensitivity and angular resolution provided by access to $Z$-band (0.9 $\mu$m) spectroscopy from IRIS and the TMT adaptive optics system. (Abridged)Comment: 19 pages, 20 figures, accepted to A

Functional effects of schizophrenia-linked genetic variants on intrinsic single-neuron excitability: A modeling study

Background: Recent genome-wide association studies (GWAS) have identified a large number of genetic risk factors for schizophrenia (SCZ) featuring ion channels and calcium transporters. For some of these risk factors, independent prior investigations have examined the effects of genetic alterations on the cellular electrical excitability and calcium homeostasis. In the present proof-of-concept study, we harnessed these experimental results for modeling of computational properties on layer V cortical pyramidal cell and identify possible common alterations in behavior across SCZ-related genes. Methods: We applied a biophysically detailed multi-compartmental model to study the excitability of a layer V pyramidal cell. We reviewed the literature on functional genomics for variants of genes associated with SCZ, and used changes in neuron model parameters to represent the effects of these variants. Results: We present and apply a framework for examining the effects of subtle single nucleotide polymorphisms in ion channel and Ca2+ transporter-encoding genes on neuron excitability. Our analysis indicates that most of the considered SCZ- related genetic variants affect the spiking behavior and intracellular calcium dynamics resulting from summation of inputs across the dendritic tree. Conclusions: Our results suggest that alteration in the ability of a single neuron to integrate the inputs and scale its excitability may constitute a fundamental mechanistic contributor to mental disease, alongside with the previously proposed deficits in synaptic communication and network behavior