Produksi dan Pemasaran Produk Manisan Pala “Ilomata” di Kelurahan Girian Weru, Kota Bitung

The purpose of this research is to describe the process of making candied nutmeg by UD Ilomata and describing Ilomata\u27s candied nutmeg marketing. The research carried out start from preparation in the April until preparation of reports in the June 2016. Data used is primary data obtained through interviews by giving questioners to the owner of UD Ilomata, and from direct observation to the production activity and marketing of Ilomata\u27s candied nutmeg. Data analysis used is descriptive analysis. Data analysis in this research is analysing market margin by calculating cost and the price margins on every channel marketing that involved in the marketing of Ilomata\u27s candied nutmeg and also calculate the Break Even Point. The result of this research shows that Ilomata\u27s candied nutmeg packed in three different packages, 3 ounce package, 2.5 ounce package, and 3 ounce package. Ilomata\u27s candied nutmeg marketed on four stores in Bitung City, two stores in Manado City, a store in Gorontalo province and the marketing directly from producer to the consumer in UD Ilomata. Biggest marketing margin is Rp 5.000 with 16% share found in the Gorontalo province\u27s channel marketing from the 2.5 ounce package and with the biggest profit margin is Rp 3.764 found in the Bitung CityMart\u27s channel marketing from the 2 ounce package. All of Ilotama\u27s channel marketing can be said efficient because total cost is small seen from the rotation of sold time product. UD Ilotmata\u27s Candied nutmeg business can hold on and exist till today because theres diligence, curiosity and entrepreneurship from the owner namely Mrs. Renny Umar.*lwths

PENGARUH KOMPONEN CITRA MEREK (BRAND IMAGE) TERHADAP LOYALITAS KONSUMEN PRODUK MINUMAN SHARE TEA DI KOTA MANADO

This study aims to determine the influence of brand image on consumer loyalty Share Tea drink in the city of Manado. In its development, bubble tea drinks into today's drinks with a variety of flavor variants that can attract consumers in all ages. Reach back the market that has declined, and to maintain the market it has gained is a challenge that Share Tea companies must face in creating consumer loyalty. This study uses data obtained from questionnaires, observations and direct interviews with the manager of Tea Share in Manado City. The analysis technique used is multiple regressions. From this research can be concluded that Components of brand image consisting of coorporate image, user image, and product image has a influence on Consumer Loyalty. The components of the brand image together have a positive influence on consumer loyalty. The coorporate image and user image individually does not significantly affect consumer loyalty, while product image individually has a significant effect on consumer loyalty

The application of cortical layer markers in the evaluation of cortical dysplasias in epilepsy

The diagnostic criteria for focal cortical dysplasia type I (FCD I) remain to be well and consistently defined. Cortical layer-specific markers (CLM) provide a potential tool for the objective assessment of any dyslamination. We studied expression patterns of recognised CLM using immunohistochemistry for N200, ER81, Otx1, Map1b (subsets of V/VI projection neurones), Pax6, Tbr1, Tbr2 (differentially expressed in cortical neurones from intermediate progenitor cells), Cux 1 (outer cortical layers) and MASH1 (ventricular zone progenitors). Dysplasia subtypes included FCD I and II, dysplasias adjacent to hippocampal sclerosis (HS) or dysembryoplastic neuroepithelial tumours (DNTs); all were compared to neonatal and adult controls. Laminar expression patterns in normal cortex were observed with Tbr1, Map1b, N200 and Otx1. FCDI cases in younger patients were characterised by abnormal expression in layer II for Tbr1 and Otx1. FCDII showed distinct labelling of balloon cells (Pax6, ER81 and Otx1) and dysmorphic neurones (Tbr 1, N200 and Map1b) supporting origins from radial glia and intermediate progenitor cells, respectively. In temporal lobe sclerosis cases with dysplasia adjacent to HS, Tbr1 and Map1b highlighted abnormal orientation of neurones in layer II. Dyslamination was not confirmed in the perilesional cortex of DNT with CLM. Finally, immature cell types (Otx1, Pax6 and Tbr2) were noted in varied pathologies. One possibility is activation of progenitor cell populations which could contribute to the pathophysiology of these lesions