1,791 research outputs found
A triclinic polymorph with Z = 3 of N,N′-bisÂ(2-pyridÂyl)oxamide
The asymmetric unit of the title compound, C12H10N4O2, contains three half-molÂecules. Each half-molÂecule is completed by crystallographic inversion symmetry. The title compound, (I), is a polymorph of the structure, (II), reported by Hsu & Chen [Eur. J. Inorg. Chem. (2004), 1488–1493]. In the original report, the compound crystallized in the tetraÂgonal space group P
21c (Z = 8), whereas the structure reported here is triclinic (P
, Z = 3). In both forms, each oxamide molÂecule is almost planar (with maximum deviations are 0.266 and 0.166 Å) and the O atoms are trans oriented. The principal difference between the two forms lies in the different hydrogen-bonding patterns. In (I), two N—H⋯O and one N—H⋯N hydrogen bonds link the molÂecules, forming a two-dimensional network, whereas in (II) there are no classical hydrogen bonds to O atoms and only weak C—H⋯O interÂactions are found along with rings of N—H⋯N bonds
Recurrence and Polya number of general one-dimensional random walks
The recurrence properties of random walks can be characterized by P\'{o}lya
number, i.e., the probability that the walker has returned to the origin at
least once. In this paper, we consider recurrence properties for a general 1D
random walk on a line, in which at each time step the walker can move to the
left or right with probabilities and , or remain at the same position
with probability (). We calculate P\'{o}lya number of this
model and find a simple expression for as, , where is
the absolute difference of and (). We prove this rigorous
expression by the method of creative telescoping, and our result suggests that
the walk is recurrent if and only if the left-moving probability equals to
the right-moving probability .Comment: 3 page short pape
The efficacy of mitochondrial targeting antiresistant epirubicin liposomes in treating resistant leukemia in animals
Ying Men*, Xiao-Xing Wang*, Ruo-Jing Li, Yan Zhang, Wei Tian, Hong-Juan Yao, Rui-Jun Ju, Xue Ying, Jia Zhou, Nan Li, Liang Zhang, Yang Yu, Wan-Liang LuState Key Laboratory of Natural and Biomimetic Drugs, and School of Pharmaceutical Sciences, Peking University, Beijing, People's Republic of China*These authors contributed equally to this manuscriptBackground: Multidrug resistance (MDR) of cancers can be circumvented by inducing programmed cell death, which is known as apoptosis. Mitochondria play a crucial role in apoptosis. Mitochondria-specific therapy would provide an efficient strategy for treating resistant cancers.Design and methods: A strategy was proposed here to overcome MDR by designing cancer mitochondria-specific drug-loaded liposomes, namely, antiresistant epirubicin mitosomes, aimed at treating resistant leukemia by targeting mitochondria. Evaluations were performed on human chronic leukemia K562, MDR K562/ADR cells, and female BALB/c nude mice xenografted with MDR K562/ADR cells. The liposomes were characterized through assays of cytotoxicity, mitochondrial targeting, caspase-9 and caspase-3, antitumor activities, and TUNEL (terminal deoxynucleotidyl transferase dUTP nick end labeling) analysis.Results: The average size of antiresistant epirubicin mitosomes was in the range of 105–115 nm. Antiresistant epirubicin mitosomes were effective in inhibiting proliferation of MDR K562/ADR cells in vitro and selectively accumulated into the mitochondria. Caspase-9 and caspase-3 activity was increased after applying antiresistant epirubicin mitosomes. In xenografted resistant MDR K562/ADR tumor in nude mice, antiresistant tumor effect of antiresistant epirubicin mitosomes was evidently observed. Apoptotic inducing effects by antiresistant epirubicin mitosomes were noticeably evidenced via mitochondrial pathway.Conclusions: Antiresistant epirubicin mitosomes had significant inhibitory effect against resistant leukemia in vitro and in vivo, hence providing a promising strategy for improving therapeutic efficacy in resistant human leukemia.Keywords: mitosomes, mitochondria signaling pathway, nude mic
Metropolitan all-pass and inter-city quantum communication network
We have demonstrated a metropolitan all-pass quantum communication network in
field fiber for four nodes. Any two nodes of them can be connected in the
network to perform quantum key distribution (QKD). An optical switching module
is presented that enables arbitrary 2-connectivity among output ports.
Integrated QKD terminals are worked out, which can operate either as a
transmitter, a receiver, or even both at the same time. Furthermore, an
additional link in another city of 60 km fiber (up to 130 km) is seamless
integrated into this network based on a trusted relay architecture. On all the
links, we have implemented protocol of decoy state scheme. All of necessary
electrical hardware, synchronization, feedback control, network software,
execution of QKD protocols are made by tailored designing, which allow a
completely automatical and stable running. Our system has been put into
operation in Hefei in August 2009, and publicly demonstrated during an
evaluation conference on quantum network organized by the Chinese Academy of
Sciences on August 29, 2009. Real-time voice telephone with one-time pad
encoding between any two of the five nodes (four all-pass nodes plus one
additional node through relay) is successfully established in the network
within 60km.Comment: 9 pages, 2 figures, 2 table
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