824 research outputs found
Adaptive Message Quantization and Parallelization for Distributed Full-graph GNN Training
Distributed full-graph training of Graph Neural Networks (GNNs) over large
graphs is bandwidth-demanding and time-consuming. Frequent exchanges of node
features, embeddings and embedding gradients (all referred to as messages)
across devices bring significant communication overhead for nodes with remote
neighbors on other devices (marginal nodes) and unnecessary waiting time for
nodes without remote neighbors (central nodes) in the training graph. This
paper proposes an efficient GNN training system, AdaQP, to expedite distributed
full-graph GNN training. We stochastically quantize messages transferred across
devices to lower-precision integers for communication traffic reduction and
advocate communication-computation parallelization between marginal nodes and
central nodes. We provide theoretical analysis to prove fast training
convergence (at the rate of O(T^{-1}) with T being the total number of training
epochs) and design an adaptive quantization bit-width assignment scheme for
each message based on the analysis, targeting a good trade-off between training
convergence and efficiency. Extensive experiments on mainstream graph datasets
show that AdaQP substantially improves distributed full-graph training's
throughput (up to 3.01 X) with negligible accuracy drop (at most 0.30%) or even
accuracy improvement (up to 0.19%) in most cases, showing significant
advantages over the state-of-the-art works
SARS-CoV Regulates Immune Function-Related Gene Expressions in Human Monocytic Cells
Background: Severe Acute Respiratory Syndrome (SARS) is characterized by acute respiratory distress (ARDS) and pulmonary fibrosis, and the monocyte/macrophage is the key player in the pathogenesis of SARS.
 
Methods: In this study, we compared the transcriptional profiles of SARS coronavirus (SARS-CoV) infected monocytic cells against that infected by coronavirus 229E (CoV-229E). Total RNA was extracted from infected DC-SIGN transfected monocytes (THP-1-DC-SIGN) at 6 and 24 h after infection and the gene expression was profiled by oligonucleotide-based microarray. 

Results: Analysis of immune-related gene expression profiles showed that 24 h after SARS-CoV infection, (i) IFN-alpha/beta-inducible and cathepsin/proteosome genes were down-regulated; (ii) the hypoxia/hyperoxia-related genes were up-regulated; and (iii) the TLR/TLR-signaling, cytokine/cytokine receptor-related, chemokine/chemokine receptor-related, the lysosome-related, MHC/chaperon-related, and fibrosis-related genes were differentially regulated. 

Conclusion: These results elucidate that monocyte/macrophage dysfunction and dysregulation of fibrosis-related genes are two important pathogenic events of SARS. 

TRUNK AND SHOULDER MUSCLE ACTIVITIES DURING PUSH-UP EXERCISE ON STABLE AND UNSTBLE SURFACES
The purpose of this study was to evaluate muscle activity of the prime movers and core stabilizers on stable and unstable surfaces during push-up exercise. Subject: Fourteen healthy male participants (age, 21.6 ±2.3 years; height, 174.7 ±8.1cm; weight, 68.2 ±16.4kg) without low back pain and shoulder injury in the past year were recruited. The participants completed push-up exercise in three conditions: on the ground, air disc and sling. EMG activities of external abdominal oblique, pectoralis major, and anterior deltoid muscles and elbow joint kinematics were recorded. Our results showed that external abdominal oblique muscle had significantly greater activity in the sling group (
WristTrack? A Mobile Healthcare Surveillance System for Wrist Recovery Exercises
Physiotherapy is an important component for injury recovery. Progressive exercises can help in facilitating recovery when executed correctly, but it can cause damaging effects when done wrongly. However, not all patients are able to make it to the hospital every time due to reasons such as post-surgery immobility. This study introduces a self-served physiotherapy system for wrist exercises (i.e., WristTrack), allowing patients to perform wrist conditioning at their own time and place of convenience. The system integrates wearable devices with mobile and web platform, to capture, visualize and provide useful metrics for both doctors and patients to make steady progression in their recovery process
Chondroprotective effects and mechanisms of resveratrol in advanced glycation end products-stimulated chondrocytes
[[abstract]]INTRODUCTION: Accumulation of advanced glycation end products (AGEs) in joints contributes to the pathogenesis of cartilage damage in osteoarthritis (OA). We aim to explore the potential chondroprotective effects of resveratrol on AGEs-stimulated porcine chondrocytes and cartilage explants. METHODS: Chondrocytes were isolated from pig joints. Activation of the IkappaB kinase (IKK)-IkappaBalpha-nuclear factor-kappaB (NF-kappaB) and c-Jun N-terminal kinase (JNK)/extracellular signal-regulated kinase (ERK)-activator protein-1 (AP-1) pathways was assessed by electrophoretic mobility shift assay (EMSA), Western blot and transfection assay. The levels of inducible nitric oxide synthase (iNOS)-NO and cyclooxygenase-2 (COX-2)-prostaglandin E2 (PGE2) were measured by Western blot, Griess reaction or ELISA. The expression and enzyme activity of matrix metalloproteinase-13 (MMP-13) were determined by real time RT/PCR and gelatin zymography, respectively. RESULTS: We show that AGEs-induced expression of iNOS and COX-2 and production of NO and PGE2 were suppressed by resveratrol. Such effects of resveratrol were likely mediated through inhibiting IKK-IkappaBalpha-NF-kappaB and JNK/ERK-AP-1 signaling pathways induced by AGEs. By targeting these critical signaling pathways, resveratrol decreased AGEs-stimulated expression and activity of MMP-13 and prevented AGEs-mediated destruction of collagen II. Histochemistry analysis further confirms that resveratrol could prevent AGEs-induced degradation of proteoglycan and aggrecan in cartilage explants. CONCLUSIONS: The present study reveals not only the effects and mechanisms regarding how resveratrol may protect cartilage from AGEs-mediated damage but also the potential therapeutic benefit of resveratrol in the treatment of OA
Suppressing Decoherence in Quantum Plasmonic Systems by Spectral Hole Burning Effect
Quantum plasmonic systems suffer from significant decoherence due to the
intrinsically large dissipative and radiative dampings. Based on our quantum
simulations via a quantum tensor network algorithm, we numerically demonstrate
the mitigation of this restrictive drawback by hybridizing a plasmonic
nanocavity with an emitter ensemble with inhomogeneously-broadened transition
frequencies. By burning two narrow spectral holes in the spectral density of
the emitter ensemble, the coherent time of Rabi oscillation for the hybrid
system is increased tenfold. With the suppressed decoherence, we move one step
further in bringing plasmonic systems into practical quantum applications
Multiple microRNAs regulate tacrolimus metabolism through CYP3A5
The CYP3A5 gene polymorphism accounts for the majority of inter-individual variability in tacmlimus pharmacokinetics. We found that the basal expression of CYP3A5 in donor grafts also played a significant role in tacrolimus metabolism under the same genetic conditions after pediatric liver transplantation. Thus, we hypothesized that some potential epigenetic factors could affect CYP3A5 expression and contributed to the variability. We used a high-throughput functional screening for miRNAs to identify miRNAs that had the most abundant expression in normal human liver and could regulate tacmlimus metabolism in HepaRG cells and HepLPCs. Four of these miRNAs (miR-29a-3p, miR-99a-5p, miR-532-5p, and miR-26-5p) were selected for testing. We found that these miRNAs inhibited tacmlimus metabolism that was dependent on CYP3A5. Putative miRNAs targeting key drug-metabolizing enzymes and transporters (DMETs) were selected using an in silico prediction algorithm. Luciferase reporter assays and functional studies showed that miR-26b-5p inhibited tacrolimus metabolism by directly regulating CYP3A5, while miR-29a-5p, miR-99a-5p, and miR-532-5p targeted HNF4a, NR1I3, and NR1I2, respectively, in turn regulating the downstream expression of CYP3A5; the corresponding target gene siRNAs markedly abolished the effects caused by miRNA inhibitors. Also, the expression of miR-29a-3p, miR-99a-5p, miR-532-5p, and miR-26b-5p in donor grafts were negatively correlated with tacmlimus C/D following pediatric liver transplantation. Taken together, our findings identify these miRNAs as novel regulators of tacrolimus metabolism
Color-tunable mixed photoluminescence emission from Alq3 organic layer in metal-Alq3-metal surface plasmon structure
This work reports the color-tunable mixed photoluminescence (PL) emission from an Alq(3) organic layer in an Au-Alq(3)-Au plasmonic structure through the combination of organic fluorescence emission and another form of emission that is enabled by the surface plasmons in the plasmonic structure. The emission wavelength of the latter depends on the Alq(3) thickness and can be tuned within the Alq(3) fluorescent spectra. Therefore, a two-color broadband, color-tunable mixed PL structure was obtained. Obvious changes in the Commission Internationale d’Eclairage (CIE) coordinates and the corresponding emission colors of Au-Alq(3)-Au samples clearly varied with the Alq(3) thickness (90, 130, and 156 nm)
Mathematical modeling of simultaneous carbon-nitrogen-sulfur removal from industrial wastewater
A mathematical model of carbon, nitrogen and sulfur removal (C-N-S) from industrial wastewater was constructed considering the interactions of sulfate-reducing bacteria (SRB), sulfide-oxidizing bacteria (SOB), nitrate-reducing bacteria (NRB), facultative bacteria (FB), and methane producing archaea (MPA). For the kinetic network, the bioconversion of C-N by heterotrophic denitrifiers (NO\ua0→\ua0NO\ua0→\ua0N), and that of C-S by SRB (SO\ua0→\ua0S) and SOB (S\ua0→\ua0S) was proposed and calibrated based on batch experimental data. The model closely predicted the profiles of nitrate, nitrite, sulfate, sulfide, lactate, acetate, methane and oxygen under both anaerobic and micro-aerobic conditions. The best-fit kinetic parameters had small 95% confidence regions with mean values approximately at the center. The model was further validated using independent data sets generated under different operating conditions. This work was the first successful mathematical modeling of simultaneous C-N-S removal from industrial wastewater and more importantly, the proposed model was proven feasible to simulate other relevant processes, such as sulfate-reducing, sulfide-oxidizing process (SR-SO) and denitrifying sulfide removal (DSR) process. The model developed is expected to enhance our ability to predict the treatment of carbon-nitrogen-sulfur contaminated industrial wastewater
Ventricular divergence correlates with epicardial wavebreaks and predicts ventricular arrhythmia in isolated rabbit hearts during therapeutic hypothermia
INTRODUCTION:
High beat-to-beat morphological variation (divergence) on the ventricular electrogram during programmed ventricular stimulation (PVS) is associated with increased risk of ventricular fibrillation (VF), with unclear mechanisms. We hypothesized that ventricular divergence is associated with epicardial wavebreaks during PVS, and that it predicts VF occurrence.
METHOD AND RESULTS:
Langendorff-perfused rabbit hearts (n = 10) underwent 30-min therapeutic hypothermia (TH, 30°C), followed by a 20-min treatment with rotigaptide (300 nM), a gap junction modifier. VF inducibility was tested using burst ventricular pacing at the shortest pacing cycle length achieving 1:1 ventricular capture. Pseudo-ECG (p-ECG) and epicardial activation maps were simultaneously recorded for divergence and wavebreaks analysis, respectively. A total of 112 optical and p-ECG recordings (62 at TH, 50 at TH treated with rotigaptide) were analyzed. Adding rotigaptide reduced ventricular divergence, from 0.13±0.10 at TH to 0.09±0.07 (p = 0.018). Similarly, rotigaptide reduced the number of epicardial wavebreaks, from 0.59±0.73 at TH to 0.30±0.49 (p = 0.036). VF inducibility decreased, from 48±31% at TH to 22±32% after rotigaptide infusion (p = 0.032). Linear regression models showed that ventricular divergence correlated with epicardial wavebreaks during TH (p<0.001).
CONCLUSION:
Ventricular divergence correlated with, and might be predictive of epicardial wavebreaks during PVS at TH. Rotigaptide decreased both the ventricular divergence and epicardial wavebreaks, and reduced the probability of pacing-induced VF during TH
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