Control of effective free energy landscape in a frustrated magnet by a field pulse

Thermal fluctuations can lift the degeneracy of a ground state manifold, producing a free energy landscape without accidentally degenerate minima. In a process known as order by disorder, a subset of states incorporating symmetry-breaking may be selected. Here, we show that such a free energy landscape can be controlled in a non-equilibrium setting as the slow motion within the ground state manifold is governed by the fast modes out of it. For the paradigmatic case of the classical pyrochlore XY antiferromagnet, we show that a uniform magnetic field pulse can excite these fast modes to generate a tunable effective free energy landscape with minima at thermodynamically unstable portions of the ground state manifold.Comment: 10 pages, 6 figures; minor revision

5-hydroxymethylcytosine is a key epigenetic regulator of keratinocyte stem cells during psoriasis pathogenesis

Epigenetic regulation is now known to play an important role in determining stem cell fate during normal tissue development and disease pathogenesis. In this study, we report loss of 5-hydroxymethylcytosine (5-hmC) mediated by ten-eleven translocation (TET) methylcytosine dioxygenases in keratinocyte stem cells (KSCs) and in their progenitor transit-amplifying (TA) cells of psoriatic lesions. We establish the DNA hydroxymethylation profile in both human psoriasis as well as in the imiquimod (IMQ)-induced mouse psoriasis model. Genome-wide mapping of 5-hmC in IMQ-treated mice epithelium revealed a loci-specific reduction of 5-hmC in genes associated with maintaining stem cell homeostasis including those involved in the RAR and Wnt/β-catenin signaling pathways. Restoration of TET expression in human KSC cultures via vitamin C treatment increased 5-hmC levels and induced more normal KSC differentiation. We found that by modulating 5-hmC levels in vitro, we could alter downstream expression of genes important in regulating stem cell homeostasis like nestin as well as IL-17R known to promote the psoriatic phenotype. Our findings demonstrate that loss of 5-hmC is a critical epigenomic phenomenon in KSCs and TA cells during psoriasis pathogenesis.2019-12-17T00:00:00

Can We Predict Vulnerability to Poverty?

There are alternative definitions of vulnerability to poverty. Most researchers prefer to define vulnerability as the probability of a household or individual falling into poverty in the future. Based on this definition and using household survey panel data from rural China, this paper attempt to assess the extent to which we can measure vulnerability to poverty. The assessment is based on comparisons between predicted vulnerability and actually observed poverty. We find that the precision of prediction, first, varies depending on the vulnerability line; our results suggest setting the line at 50 per cent in order to improve predictive power. Second, precision depends on how permanent income is estimated. Assuming log-normal distribution of income, it is preferable to use past weighted average income as an estimate of permanent income rather than using regressions to gage permanent income. And third, prediction precision depends on the chosen poverty line. More accurate measurement of vulnerability to poverty is obtained with a higher poverty line of US$2 instead of US$1.vulnerability, poverty, permanent income, transitory income

Competing electronic orders on Kagome lattices at van Hove filling

The electronic orders in Hubbard models on a Kagome lattice at van Hove filling are of intense current interest and debate. We study this issue using the singular-mode functional renormalization group theory. We discover a rich variety of electronic instabilities under short range interactions. With increasing on-site repulsion $U$, the system develops successively ferromagnetism, intra unit-cell antiferromagnetism, and charge bond order. With nearest-neighbor Coulomb interaction $V$ alone (U=0), the system develops intra-unit-cell charge density wave order for small $V$, s-wave superconductivity for moderate $V$, and the charge density wave order appears again for even larger $V$. With both $U$ and $V$, we also find spin bond order and chiral $d_{x^2 - y^2} + i d_{xy}$ superconductivity in some particular regimes of the phase diagram. We find that the s-wave superconductivity is a result of charge density wave fluctuations and the squared logarithmic divergence in the pairing susceptibility. On the other hand, the d-wave superconductivity follows from bond order fluctuations that avoid the matrix element effect. The phase diagram is vastly different from that in honeycomb lattices because of the geometrical frustration in the Kagome lattice.Comment: 8 pages with 9 color figure

Quantum dimer model for the spin-1/2 kagome Z2 spin liquid

We revisit the description of the low-energy singlet sector of the spin-1/2 Heisenberg antiferromagnet on kagome in terms of an effective quantum dimer model. With the help of exact diagonalizations of appropriate finite-size clusters, we show that the embedding of a given process in its kagome environment leads to dramatic modifications of the amplitudes of the elementary loop processes, an effect not accessible to the standard approach based on the truncation of the Hamiltonian to the nearest-neighbour valence-bond basis. The resulting parameters are consistent with a Z$_2$ spin liquid rather than with a valence-bond crystal, in agreement with the last density matrix renormalization group results.Comment: Potential terms of the effective QDM include