1 research outputs found
TRPC6 Is Found in Distinct Compartments of the Human Kidney
In the context of renal proteinuric diseases, TRPC6 has been shown to play an important
role in ultrafiltration associated with the slit diaphragm through the control of the intracellular Ca2+
concentration in the podocytes of glomeruli. However, to date, the properties of TRPC6 have been
studied mainly in cell lines or in animal models. Therefore, the aim of the study presented here was to
investigate the presence and distribution of TRPC6 in human kidneys in order to possibly verify the
applicability of the results previously obtained in nonhuman experiments. For this purpose, kidneys
from nine cadavers were prepared for immunohistochemical staining and were supplemented with a
fresh human kidney obtained by nephrectomy. TRPC6 was detected in glomeruli and in the parietal
epithelial cells of Bowman’s capsule. Larger amounts were detected in the tubular system and
collecting ducts. In contrast to the peritubular capillary bed, which showed no immune reaction, the
cortical resistance vessels showed mild TRPC6 staining. In conclusion, our studies on the expression
of TRPC6 in human kidney tissue support the translational concept of the involvement of TRPC6 in
various renal diseases and reveal new aspects of the distribution of TRPC6 in the human kidney