The Enigmatic Radio Afterglow of GRB 991216

We present wide-band radio observations spanning from 1.4 GHz to 350 GHz of the afterglow of GRB 991216, taken from 1 to 80 days after the burst. The optical and X-ray afterglow of this burst were fairly typical and are explained by a jet fireball. In contrast, the radio light curve is unusual in two respects: (a) the radio light curve does not show the usual rise to maximum flux on timescales of weeks and instead appears to be declining already on day 1 and (b) the power law indices show significant steepening from the radio through the X-ray bands. We show that the standard fireball model, in which the afterglow is from a forward shock, is unable to account for (b) and we conclude that the bulk of the radio emission must arise from a different source. We consider two models, neither of which can be ruled out with the existing data. In the first (conventional) model, the early radio emission is attributed to emission from the reverse shock as in the case of GRB 990123. We predict that the prompt optical emission would have been as bright (or brighter) than 8th magnitude. In the second (exotic) model, the radio emission originates from the forward shock of an isotropically energetic fireball (10^54 erg) expanding into a tenuous medium (10^-4 cm^-3). The resulting fireball would remain relativistic for months and is potentially resolvable with VLBI techniques. Finally, we note that the near-IR bump of the afterglow is similar to that seen in GRB 971214 and no fireball model can explain this bump.Comment: ApJ, submitte

Detection of fast radio transients with multiple stations: a case study using the Very Long Baseline Array

Recent investigations reveal an important new class of transient radio phenomena that occur on sub-millisecond timescales. Often transient surveys' data volumes are too large to archive exhaustively. Instead, an on-line automatic system must excise impulsive interference and detect candidate events in real-time. This work presents a case study using data from multiple geographically distributed stations to perform simultaneous interference excision and transient detection. We present several algorithms that incorporate dedispersed data from multiple sites, and report experiments with a commensal real-time transient detection system on the Very Long Baseline Array (VLBA). We test the system using observations of pulsar B0329+54. The multiple-station algorithms enhanced sensitivity for detection of individual pulses. These strategies could improve detection performance for a future generation of geographically distributed arrays such as the Australian Square Kilometre Array Pathfinder and the Square Kilometre Array.Comment: 12 pages, 14 figures. Accepted for Ap

The Broadband Afterglow of GRB980329

We present radio observations of the afterglow of the bright gamma-ray burst GRB980329 made between one month and several years after the burst, a re-analysis of previously published submillimeter data, and late-time optical and near-infrared (NIR) observations of the host galaxy. From the absence of a spectral break in the optical/NIR colors of the host galaxy, we exclude the earlier suggestion that GRB980329 lies at a redshift of z >~5. We combine our data with the numerous multi-wavelength observations of the early afterglow, fit a comprehensive afterglow model to the entire broadband dataset, and derive fundamental physical parameters of the blast-wave and its host environment. Models for which the ejecta expand isotropically require both a high circumburst density and extreme radiative losses from the shock. No low density model (n << 10 cm^{-3}) fits the data. A burst with a total energy of ~ 10^{51} erg, with the ejecta narrowly collimated to an opening angle of a few degrees, driven into a surrounding medium with density ~ 20 cm^{-3}, provides a satisfactory fit to the lightcurves over a range of redshifts.Comment: 27 pages, incl. 6 figures, minor revisions (e.g. added/updated references) Accepted by Ap

A Continuous-Time Dynamic Factor Model for Intensive Longitudinal Data Arising from Mobile Health Studies

Intensive longitudinal data (ILD) collected in mobile health (mHealth) studies contain rich information on multiple outcomes measured frequently over time that have the potential to capture short-term and long-term dynamics. Motivated by an mHealth study of smoking cessation in which participants self-report the intensity of many emotions multiple times per day, we propose a dynamic factor model that summarizes the ILD as a low-dimensional, interpretable latent process. This model consists of two submodels: (i) a measurement submodel -- a factor model -- that summarizes the multivariate longitudinal outcome as lower-dimensional latent variables and (ii) a structural submodel -- an Ornstein-Uhlenbeck (OU) stochastic process -- that captures the temporal dynamics of the multivariate latent process in continuous time. We derive a closed-form likelihood for the marginal distribution of the outcome and the computationally-simpler sparse precision matrix for the OU process. We propose a block coordinate descent algorithm for estimation. Finally, we apply our method to the mHealth data to summarize the dynamics of 18 different emotions as two latent processes. These latent processes are interpreted by behavioral scientists as the psychological constructs of positive and negative affect and are key in understanding vulnerability to lapsing back to tobacco use among smokers attempting to quit.Comment: Main text is 19 pages with 4 figures and 1 table. Supporting material is 25 page

Responsive Sensory Evaluation to Develop Flexible Taste-Masked Paediatric Primaquine Tablets against Malaria for Low-Resource Settings

Primaquine is an important antimalarial drug for malaria transmission blocking and radical cure, but it is not currently available in child-friendly formulations in appropriate doses. Adult-strength tablets are often crushed and dissolved in water to obtain the required dose, which exposes the drug’s bitter taste. As part of the developing paediatric primaquine (DPP) project, this study adopted a responsive sensory pharmaceutics approach by integrating real-time formulation development and pre-clinical taste assessment to develop palatable, flavour-infused primaquine tablets. A design of experiment (DoE) approach was used to screen different taste-masking agents and excipient blends with trained, expert sensory assessors, with quinine hydrochloride as a model bitter tastant. The taste-masking efficacy of selected prototype formulation blends was validated with naïve assessors using the highest 15 mg primaquine dose. The mean bitterness intensity rating, measured on a discrete 11-point scale, was halved from 7.04 for the unflavoured control to 2.74–3.70 for the formulation blends. Sucralose had the biggest impact on bitterness suppression and improving palatability. Two different flavouring systems have been developed, and their acceptability in paediatric patients will be assessed as part of upcoming validation field clinical trials in Africa

Spectroscopic Identification of Massive Galaxies at z~2.3 with Strongly Suppressed Star Formation

We present first results of a spectroscopic survey targeting K-selected galaxies at z=2.0-2.7 using the GNIRS instrument on Gemini-South. We obtained near-infrared spectra with a wavelength coverage of 1.0-2.5 micron for 26 K-bright galaxies (K<19.7) selected from the MUSYC survey using photometric redshifts. We successfully derived spectroscopic redshifts for all 26 galaxies using rest-frame optical emission lines or the redshifted Balmer/4000 Angstrom break. Twenty galaxies have spectroscopic redshifts in the range 2.0<z<2.7, for which bright emission lines like Halpha and [OIII] fall in atmospheric windows. Surprisingly, we detected no emission lines for nine of these 20 galaxies. The median 2 sigma upper limit on the rest-frame equivalent width of Halpha for these nine galaxies is ~10 Angstrom. The stellar continuum emission of these same nine galaxies is best fitted by evolved stellar population models. The best-fit star formation rate (SFR) is zero for five out of nine galaxies, and consistent with zero within 1 sigma for the remaining four. Thus, both the Halpha measurements and the independent stellar continuum modeling imply that 45% of our K-selected galaxies are not forming stars intensely. This high fraction of galaxies without detected line emission and low SFRs may imply that the suppression of star formation in massive galaxies occurs at higher redshift than is predicted by current CDM galaxy formation models. However, obscured star formation may have been missed, and deep mid-infrared imaging is needed to clarify this situation.Comment: Accepted for publication in ApJ Letter

Discovery of the INTEGRAL X/Gamma-ray transient IGR J00291+5934: a Comptonised accreting ms pulsar ?

We report the discovery of a high-energy transient with the IBIS/ISGRI detector on board the INTEGRAL observatory. The source, namely IGR J00291+5934, was first detected on 2nd December 2004 in the routine monitoring of the IBIS/ISGRI 20--60 keV images. The observations were conducted during Galactic Plane Scans, which are a key part of the INTEGRAL Core Programme observations. After verifying the basic source behaviour, the discovery was announced on 3rd December. The transient shows a hard Comptonised spectrum, with peak energy release at about 20 keV and a total luminosity of ~ 0.9E36 erg/s in the 5--100 keV range, assuming a distance of 3 kpc. Following the INTEGRAL announcement of the discovery of IGR J00291+5934, a number of observations were made by other instruments. We summarise the results of those observations and, together with the INTEGRAL data, identifiy IGR J00291+5934 as the 6th member of a class of accreting X-ray millisecond pulsars.Comment: Accepted for publication as an A&A Letter 24/01/2005. 5 pages, 2 figure