Comparison of demographics and percentage with known HIV-associated cancer cases between those with HIV(+) serology and those who met clinical criteria only.

<p>[<u>Notes</u>: *Statistically significant difference (p = 0.005) between positive serology group (n = 47) and clinical criteria only group (n = 124) with respect to the patient characteristic (Chi-square test)].</p

Level of strength-of-evidence of HIV infection/AIDS in 171 cancer cases that were registered.

<p>Of the subsequent confirmed HIV(+) serology 12 were identified at the Comprehensive Care Clinic and 10 at the Department of Radiation Oncology at Kenyatta National Hospital. [<u>Notes</u>: *Statistically significant difference (p = 0.022) between positive serology group (n = 47) and clinical criteria only group (n = 124) with respect to the level strength-of-evidence (Chi-square test)].</p

Tumor types of 171 cancer cases with hierarchal association of HIV infection/AIDS.

<p>Of these total cases, 118 (69%) had demonstrable HIV association (i.e., KS, cervix, NHL, conjunctiva and Hodgkin’s disease) and the remaining 53 would be considered non-AIDS-defining cancer. [<u>Notes</u>: <b><i>Bold italics</i></b> – known HIV-associated malignancy; NOS – not otherwise specified].</p

Nairobi Cancer Registry (NCR) – reporting entities comprising this cancer population-based registry utilized for this study number of cases that met strength-of-evidence criteria for cancer-AIDS (HIV infection) match.

<p>Nairobi Cancer Registry (NCR) – reporting entities comprising this cancer population-based registry utilized for this study number of cases that met strength-of-evidence criteria for cancer-AIDS (HIV infection) match.</p

Association between cytoplasmic phospho-MAPK and pathological classification.

<p>Association between cytoplasmic phospho-MAPK and pathological classification.</p

Association between cytoplasmic phospho-Akt and pathological classification.

<p>Association between cytoplasmic phospho-Akt and pathological classification.</p

Association between nuclear phospho-EGFR and pathological classification.

<p>Association between nuclear phospho-EGFR and pathological classification.</p

Prevalence of high-risk HPV genotypes in conjunctival squamous cell carcinoma by real-time RQ PCR assay.

<p>Tumor DNA extraction was performed using Pico Pure DNA Extraction kit. The viral DNA of 4 HPV genotypes were determined using a TaqMan-based real-time quantitative PCR analysis. Type-specific primers and probes for HPV types 16, 18, 52 and 59 were selected to target genome segments of the E6/E7 region and synthesized by Applied Biosystems. RNase-P as endogenous control for each sample (in duplicate) was applied in this assay. Amplification results from the endogenous control were used to normalize the amplification results from the target HPV types. Finally, Ct, ΔCt, ΔΔCt, RQ and gene expression plots were generated by the ABI 7500 Fast System SDS Software (Version 1.4).</p

Association between EGFR mRNA expression and pathological classification.

<p>Association between EGFR mRNA expression and pathological classification.</p

Pathological classification of Patient Specimens Infected by HPV 16/18 Genotypes.

<p>Pathological classification of Patient Specimens Infected by HPV 16/18 Genotypes.</p