Teachers’ Experiences of School-Wide Positive Behavior Interventions and Supports: A Qualitative Study

The purpose of this study was to describe the unique personal experiences of teachers implementing School-Wide Positive Behavior Interventions and Supports (SWPBIS) in their classroom and identify themes within their experiences that impacted their desire or ability to implement SWPBIS. Phenomenological analysis was utilized to analyze data to develop a greater understanding of how teachers view and experience SWPBIS, and identify factors that aid and hinder acceptance and implementation. Four participants involved in implementing Tier 1 of SWPBIS were interviewed and asked about their experiences implementing SWPBIS. Participants described a number of experiences that negatively impacted their belief in, attitude toward, and use of SWPBIS. Themes identified that negatively impacted teachers’ belief in, attitude toward, and use of SWPBIS included: (a) reluctance and negative emotional experiences upon introduction and training, (b) personal and philosophical conflict with SWPBIS, (c) insufficient knowledge and training, and (d) lack of resources. Participants also described experiences that increased their belief in, attitude toward, and use of SWPBIS. These themes included: (a) participants utilizing Responsive Classroom to manage behavior in their classroom, (b) seeking out independent professional development, (c) peer-to-peer mentoring, and (d) implementation team training and support. Implications of this study for administrators, researchers, teachers, and clinical psychologists are discussed along with limitations and recommendations for future research

The stochastic behavior of a molecular switching circuit with feedback

Background: Using a statistical physics approach, we study the stochastic switching behavior of a model circuit of multisite phosphorylation and dephosphorylation with feedback. The circuit consists of a kinase and phosphatase acting on multiple sites of a substrate that, contingent on its modification state, catalyzes its own phosphorylation and, in a symmetric scenario, dephosphorylation. The symmetric case is viewed as a cartoon of conflicting feedback that could result from antagonistic pathways impinging on the state of a shared component. Results: Multisite phosphorylation is sufficient for bistable behavior under feedback even when catalysis is linear in substrate concentration, which is the case we consider. We compute the phase diagram, fluctuation spectrum and large-deviation properties related to switch memory within a statistical mechanics framework. Bistability occurs as either a first-order or second-order non-equilibrium phase transition, depending on the network symmetries and the ratio of phosphatase to kinase numbers. In the second-order case, the circuit never leaves the bistable regime upon increasing the number of substrate molecules at constant kinase to phosphatase ratio. Conclusions: The number of substrate molecules is a key parameter controlling both the onset of the bistable regime, fluctuation intensity, and the residence time in a switched state. The relevance of the concept of memory depends on the degree of switch symmetry, as memory presupposes information to be remembered, which is highest for equal residence times in the switched states. Reviewers: This article was reviewed by Artem Novozhilov (nominated by Eugene Koonin), Sergei Maslov, and Ned Wingreen.Comment: Version published in Biology Direct including reviewer comments and author responses, 28 pages, 7 figure

EPR of Cu\u3csup\u3e2+\u3c/sup\u3e Prion Protein Constructs at 2 GHz Using the \u3cem\u3eg\u3c/em\u3e\u3csub\u3e⊥\u3c/sub\u3e Region to Characterize Nitrogen Ligation

A double octarepeat prion protein construct, which has two histidines, mixed with copper sulfate in a 3:2 molar ratio provides at most three imidazole ligands to each copper ion to form a square-planar Cu2+ complex. This work is concerned with identification of the fourth ligand. A new (to our knowledge) electron paramagnetic resonance method based on analysis of the intense features of the electron paramagnetic resonance spectrum in the g⊥ region at 2 GHz is introduced to distinguish between three and four nitrogen ligands. The methodology was established by studies of a model system consisting of histidine imidazole ligation to Cu2+. In this spectral region at 2 GHz (S-band), g-strain and broadening from the possible rhombic character of the Zeeman interaction are small. The most intense line is identified with the MI = +1/2 extra absorption peak. Spectral simulation demonstrated that this peak is insensitive to cupric Ax and Ay hyperfine interaction. The spectral region to the high-field side of this peak is uncluttered and suitable for analysis of nitrogen superhyperfine couplings to determine the number of nitrogens. The spectral region to the low-field side of the intense extra absorption peak in the g⊥ part of the spectrum is sensitive to the rhombic distortion parameters Ax and Ay. Application of the method to the prion protein system indicates that two species are present and that the dominant species contains four nitrogen ligands. A new loop-gap microwave resonator is described that contains ∼1 mL of frozen sample

The public health engineer\u27s part on a health program

In this work the Public Health Engineer should not be confused with the Sanitary Engineer as the term is commonly used today. The Sanitary Engineer is primarily a designer or builder. He is, in fact, a civil and hydraulic engineer specializing in a rather restricted field, confined for the most part to works relating to municipal water supply and sewage. The Public Health Engineer on the other hand is primarily a student and worker in the field of public health. The range of his activities is wider, and his training and knowledge are of essentially different character. It is not so important that he know how to build a sewer as that he know why sewers are necessary and what results may be anticipated from the discharge of their contents without treatment into a body of water. Trained to think with the clearness and acuracy [sic] of an engineer, he employs as his material the data of physics, chemistry, and biology which underlie the present-day practice of public health --Introduction, page 7-8