10,524 research outputs found
Thermal and oxidative degradation of aromatic and heterocyclic polymers Progress report, 1 Aug. 1968 - 1 Feb. 1969
Thermal and oxydative decomposition of aromatic and heterocyclic polymer
Thermal and oxidative degradation of aromatic and heterocyclic polymers Progress report, May 1, 1966 - Aug. 1, 1967
Thermogravimetric measurements on high temperature polycarbonate pyrolytic product
Polymer decomposition initiated by high energy radiation Progress report, Nov. 1965 - May 1966
Polymer decomposition initiated by high energy radiatio
Thermogravimetric instrument
Thermogravimetric instrument to measure volatility under both isothermal and nonisothermal conditions and to study thermal decompositio
Automatic closed circuit television arc guidance control Patent
Automatic closed circuit television arc guidance control for welding joint
Closed circuit TV system automatically guides welding arc
Closed circuit television /CCTV/ system automatically guides a welding torch to position the welding arc accurately along weld seams. Digital counting and logic techniques incorporated in the control circuitry, ensure performance reliability
Quantum magnetism with ultracold molecules
This article gives an introduction to the realization of effective quantum
magnetism with ultracold molecules in an optical lattice, reviews experimental
and theoretical progress, and highlights future opportunities opened up by
ongoing experiments. Ultracold molecules offer capabilities that are otherwise
difficult or impossible to achieve in other effective spin systems, such as
long-ranged spin-spin interactions with controllable degrees of spatial and
spin anisotropy and favorable energy scales. Realizing quantum magnetism with
ultracold molecules provides access to rich many-body behaviors, including many
exotic phases of matter and interesting excitations and dynamics.
Far-from-equilibrium dynamics plays a key role in our exposition, just as it
did in recent ultracold molecule experiments realizing effective quantum
magnetism. In particular, we show that dynamical probes allow the observation
of correlated many-body spin physics, even in polar molecule gases that are not
quantum degenerate. After describing how quantum magnetism arises in ultracold
molecules and discussing recent observations of quantum magnetism with polar
molecules, we survey prospects for the future, ranging from immediate goals to
long-term visions.Comment: 21 pages, 6 figures, 1 table. Review articl
Structural modeling and functional analysis of the essential ribosomal processing protease Prp from Staphylococcus aureus
In Firmicutes and related bacteria, ribosomal large subunit protein L27 is encoded with a conserved N-terminal extension that is removed to expose residues critical for ribosome function. Bacteria encoding L27 with this N-terminal extension also encode a sequence-specific cysteine protease, Prp, which carries out this cleavage. In this work, we demonstrate that L27 variants with an un-cleavable N-terminal extension, or lacking the extension (pre-cleaved), are unable to complement an L27 deletion in Staphylococcus aureus. This indicates that N-terminal processing of L27 is not only essential but possibly has a regulatory role. Prp represents a new clade of previously uncharacterized cysteine proteases, and the dependence of S. aureus on L27 cleavage by Prp validates the enzyme as a target for potential antibiotic development. To better understand the mechanism of Prp activity, we analyzed Prp enzyme kinetics and substrate preference using a fluorogenic peptide cleavage assay. Molecular modeling and site-directed mutagenesis implicate several residues around the active site in catalysis and substrate binding, and support a structural model in which rearrangement of a flexible loop upon binding of the correct peptide substrate is required for the active site to assume the proper conformation. These findings lay the foundation for the development of antimicrobials that target this novel, essential pathway
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