Metal contents in the edible tissues of camel and sheep: human dietary intake and risk assessment in Saudi Arabia

Camel and sheep meats are considered major sources of animal-derived protein, vitamins and minerals in certain parts of the world such as Arabian Peninsula, India and Middle East countries. Despite these health benefits, the safety of sheep and camel meat may be compromised by the presence of heavy metals. The monitoring of metal concentrations is therefore important to ensure compliance with food safety regulations and consequent consumer protection. This study was undertaken to estimate the toxic metals (lead, cadmium and arsenic) and the essential trace elements (copper, zinc and iron) contents in the edible tissues (muscle, livers and kidneys) of both camel and sheep slaughtered at Al-Ahsa, Saudi Arabia. The dietary intake and human health risk assessment of the examined metals due to consumption of these tissues by Saudi population were estimated. The results indicate that the tested metals were detected in all the tissue samples with variable concentrations. Residual concentrations of all examined metals were within the maximum permissible limits set by European Union, Food and Agricultural Organization except for the arsenic. Human health risk assessment revealed that the detected concentrations of cadmium and lead might not possess health hazards. Nevertheless, care is imperative regarding As especially in Saudi Arabia because of the excessive meat consumption

Determination of polycyclic aromatic hydrocarbon content in heat-treated meat retailed in Egypt: Health risk assessment, benzo[a]pyrene induced mutagenicity and oxidative stress in human colon (CaCo-2) cells and protection using rosmarinic and ascorbic acids

This study was undertaken to estimate the concentrations of the formed polycyclic aromatic hydrocarbons (PAHs) in heat-treated (boiled, pan-fried and grilled) meats collected from Egypt. Dietary intakes and cancer risks of PAHs among Egyptian adults were calculated. Benzo[a]pyrene (B[a]P)-induced mutagenicity and oxidative stress in human colon (CaCo-2) cell line and mechanisms behind such effects were also investigated. Finally, protection trials using rosmarinic (RMA) and ascorbic acids (ASA) were carried out. The results indicated formation of PAHs at high levels in the heat-treated meats. Calculated incremental life time cancer risk among Egyptian adults were 7.05179E - 07, 7.00604 E - 06 and 1.86069 E - 05 due to ingestion of boiled, panfried and grilled meats, respectively. B[a]P-exposed CaCo-2 cells had high abilities for mutagenicity (490.05 +/- 21.37 His + revertants) and production of reactive oxygen species. RMA and ASA protected CaCo-2 cells via reduction of B[a]P-induced mutagenicity and oxidative stress and upregulation of phase II detoxification enzymes and xenobiotic transporters