Exploring The Relationship Between Egris and The Need For Mechanical Ventilation In Guillain Barré Syndrome

Background and objective: Guillain-Barré syndrome (GBS) is an immune system-mediated polyradiculoneuropathy that accounts for approximately 100,000 new patients per year globally. GBS has also been linked to respiratory failure in 20% to 40% of cases. The objective of this study was to find an association between Erasmus GBS respiratory insufficiency score (EGRIS) and the need for mechanical ventilation. Methods: We conducted our cross-sectional study at department of Neurology, Pakistan Institute of Medical Sciences from November 2019 to February 2020. Sixty patients were selected for this study. Data including demographic profile, variant of GBS, and EGRIS was calculated from all the study participants. Data was entered and analyzed using SPSS version 25. Results: All 60 patients enrolled in the study underwent continuous monitoring during admission time. Out of 60 patients, three (5%) endured mechanical ventilation with a mean EGRIS of 4.5. Others who didn\u27t need mechanical ventilation had mean EGRIS of 1.5. The three patients requiring mechanical ventilation were one each from Acute Inflammatory Demyelinating polyradiculoneuropathy, Acute Motor Axonal Neuropathy, and Acute Motor and Sensory Axonal Neuropathy variants of GBS. p-value was non-significant for the presented data. Conclusion: EGRIS could not meet statistical significance in identifying the requirement of mechanical ventilation for GBS in this study. This may be due to low sample size

Complex Formation during SID and Its Effect on Proton Mobility

Surface-induced dissociation (SID) of protonated peptides is a vibrant, active field of study. Significant focus has been placed on understanding the mechanism of dissociation, with most approaches using equilibrium thermodynamic arguments. Here, we explore the dynamics of SID using atomistic simulations. We find that it is common for complexes of peptide fragments to form following dissociation. An important consequence of complexation is that excess protons are not isolated following initial fragmentation and can participate in subsequent chemical reactions. Our work reveals an alternate mechanism for proton mobility that, to our knowledge, has not been previously observed in simulations

Stretched flow of Oldroyd-B fluid with Cattaneo-Christov heat flux

The objective of present attempt is to analyse the flow and heat transfer in the flow of an Oldroyd-B fluid over a non-linear stretching sheet having variable thickness. Characteristics of heat transfer are analyzed with temperature dependent thermal conductivity and heat source/sink. Cattaneo-Christov heat flux model is considered rather than Fourier’s law of heat conduction in the present flow analysis. Thermal conductivity varies with temperature. Resulting partial differential equations through laws of conservation of mass, linear momentum and energy are converted into ordinary differential equations by suitable transformations. Convergent series solutions for the velocity and temperature distributions are developed and discussed. Keywords: Oldroyd-B fluid, Variable sheet thickness, Cattaneo-Christov heat flux model, Heat source/sink, Temperature dependent thermal conductivit

Numerical investigation of magnetohydrodynamic stagnation point flow with variable properties

This article is concerned with the two-dimensional flow of Powell–Eyring fluid with variable thermal conductivity. The flow is caused due to a stretching cylinder. Temperature dependent thermal conductivity is considered. Both numerical and analytic solutions are obtained and compared. Analytic solution is found by homotopy analysis method. Numerical solution by shooting technique is presented. Discussion to different physical parameters for the velocity and temperature is assigned. It is observed that the velocity profile enhances for larger magnetic parameter. It is also further noted that for increasing the value of Prandtl number temperature profile decreases

Scientific Validation of Ethnomedicinal Use of Ipomoea batatas L. Lam. as Aphrodisiac and Gonadoprotective Agent against Bisphenol A Induced Testicular Toxicity in Male Sprague Dawley Rats

Sweet potato (Ipomoea batatas L. Lam.), known as “Shakarqandi” in Pakistan, is an imperative root vegetable with large size, traditionally used as aphrodisiac, antiprostatic, anti-inflammatory, antidiabetic, cardiotonic, and anticancer agent. Present study was conducted to gauge aphrodisiac potential of Ipomoea batatas ethyl acetate (IPT-EA, IPA-EA) and methanol (IPT-M, IPA-M) extracts from tuber and aerial part, respectively, via behavioral and biochemical tests and their possible protective role in BPA-induced gonadotoxicity at the dose 300 mg/kg in male Sprague Dawley rats. Phytochemical analysis was done qualitatively and quantitatively through total phenolic and flavonoid content (TPC and TFC) and high performance liquid chromatographic (HPLC-DAD) fingerprinting while antioxidant profiling used multimode in vitro assays. To calculate sexual excitement mount latency, intromission latency, mount frequency, intromission frequency, ejaculatory latency, and postejaculatory interval were examined while for biochemical ratification semen characteristics, levels of testosterone, follicle stimulating hormone (FSH), luteinizing hormone (LH), and estradiol were measured. Gonadoprotective ability was assessed through comet assay and histomorphological examination of testes. Qualitative analysis ensured the presence of phenols, flavonoids, tannins, anthocyanin, saponins, coumarins, terpenoids, and betacyanin. Quantitatively maximal TPC (304.32±7.20 μg GAE/mg dry extract) and TFC (214.77±4.09 μg QE/mg DE) were estimated in IPA-EA extract. IPT-EA yielded maximum rutin (7.3±0.12) and myricetin (2.7±0.14 μg/mg DE) while IPA-EA and IPA-M yielded maximum caffeic acid (4.05±0.22 and 1.92±0.17 μg/mg DE, respectively) in HPLC-DAD analysis. Extracts enhanced sexual excitement, improved semen quality, levels of testosterone, FSH, LH, and estradiol, and successfully attenuated toxic effects of BPA. Levels of endogenous antioxidant enzymes (CAT, SOD, POD, and GSH) were restored and NO abundance was minimized. Significant stimulation in sexual behavior, amelioration of toxicity symptoms, elevated spermatic production, raised viability, vitalized levels of gonadal hormones, maintained endogenous enzymes, genoprotection, and reformed testicular histology endorsed I. batatas as a better aphrodisiac alternative and gonadoprotective agent