20 research outputs found
Heme Oxygenase-1 Accelerates Cutaneous Wound Healing in Mice
Heme oxygenase-1 (HO-1), a cytoprotective, pro-angiogenic and anti-inflammatory enzyme, is strongly induced in injured tissues. Our aim was to clarify its role in cutaneous wound healing. In wild type mice, maximal expression of HO-1 in the skin was observed on the 2nd and 3rd days after wounding. Inhibition of HO-1 by tin protoporphyrin-IX resulted in retardation of wound closure. Healing was also delayed in HO-1 deficient mice, where lack of HO-1 could lead to complete suppression of reepithelialization and to formation of extensive skin lesions, accompanied by impaired neovascularization. Experiments performed in transgenic mice bearing HO-1 under control of keratin 14 promoter showed that increased level of HO-1 in keratinocytes is enough to improve the neovascularization and hasten the closure of wounds. Importantly, induction of HO-1 in wounded skin was relatively weak and delayed in diabetic (db/db) mice, in which also angiogenesis and wound closure were impaired. In such animals local delivery of HO-1 transgene using adenoviral vectors accelerated the wound healing and increased the vascularization. In summary, induction of HO-1 is necessary for efficient wound closure and neovascularization. Impaired wound healing in diabetic mice may be associated with delayed HO-1 upregulation and can be improved by HO-1 gene transfer
A steric approach for teh design of antihistamines with low muscarinic receptor antagonism.
Non-Imidazole histamine H3 Ligands, Part 2: New 2-substituted benzothiazoles as histamine H3 antagonists.
Histamine H1 receptor ligands Part I. Novel thiazol-4-ylethanamine derivatives: synthesis and in vitro pharmacology.
A series of 2-substituted thiazol-4-ylethanamines have been synthesized and tested for their histaminergic
A steric approach for the design of antihistamines with low muscarinic receptor antagonism
Synthesis of some thiazolyl aminobenzothiazole derivatives as potential antibacterial, antifungal and anthelmintic agents
Survival after Severe acute Chromic Acid Poisoning Complicated with Renal and Liver Failure
2-(4-Alkylpiperazin-1-yl)quinolines as a New Class of Imidazole-Free Histamine H3 Receptor Antagonists
Synthesis and pharmacological identification of neutral histamine H1-receptor antagonists
In the present study we searched for neutral antagonists for the human histamine