Drug-induced liver injury due to the long-term oral administration of rosuvastatin

A 67-year-old man was admitted to our hospital presenting with a liver injury. He had used several types of oral medication for the prior 2 years, including rosuvastatin calcium for hypertension, hyperlipidemia, and prostatic hypertrophy. His liver dysfunction was noted for the first time in February 2013, and at re-examination in March 2013 he showed exacerbation of the liver dysfunction, he was admitted to our hospital at that time. We stopped all of his oral medications, and his liver function improved steadily. We conducted a drug-induced lymphocyte transformation test (DLST), and the rosuvastatin calcium result was positive. He was diagnosed as having a drug-induced (by rosvastatin calcium) liver injury. He resumed oral medications other than rosuvastatin calcium from the time of discharge, with no exacerbation of liver dysfunction since then. Reports of drug-induced liver injury due to drugs with a long-term oral administration are extremely rare. We discuss the relevant literature herein

NoSQL Schema Design for Time-Dependent Workloads

In this paper, we propose a schema optimization method for time-dependent workloads for NoSQL databases. In our proposed method, we migrate schema according to changing workloads, and the estimated cost of execution and migration are formulated and minimized as a single integer linear programming problem. Furthermore, we propose a method to reduce the number of optimization candidates by iterating over the time dimension abstraction and optimizing the workload while updating constraints

ブランド・コミュニティにおける ロイヤルティ向上の理論的研究

本稿の目的は、ブランド・コミュニティにおいてロイヤルティが向上する因果モデルを明らかにするために必要な課題を理論的に導き出すことにある。具体的には、既存研究で提示された2つの因果モデルを比較検討する。この2つのモデルは、自動車オーナーズクラブを対象にほとんど同じ調査方法を用いて導かれたにもかかわらずロイヤルティを向上させる先行要因が異なる、という大きなちがいがある。このようなちがいが生じた理由は、一方のモデルの適用範囲が他方のモデルのそれを包含しているからであると考えることもできる。しかし、両モデルの適用範囲は部分的にしか重なり合わないと考えることもできる。したがって、2つのモデルの適用範囲を明らかにするためには、外国産メーカーの自動車オーナーズクラブという特殊な対象に既存研究と同じ調査方法を用いてモデルを検証する必要がある

Liver Sarcoidosis with Unique MRI Images Using Gadolinium Ethoxybenzyl Diethylenetriamine Pentaacetic Acid

Sarcoidosis is a systemic disease characterized by the formation of non-caseating granulomas in multiple organs. In the diagnosis of sarcoidosis, imaging modalities such as ultrasonography, computed tomography (CT) and magnetic resonance imaging (MRI) are useful;however, there are few reports of MRI imaging using gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB) MRI. A 46-year-old Japanese female with suspected pulmonary sarcoidosis was admitted to our hospital because low-density mottles in the liver were observed incidentally by chest CT. The low-density mottles were not enhanced at the arterial phase or portal phase by abdominal CT and MRI, and decreased uptake was observed in the hepatobiliary phase of Gd-EOB MRI. No hematological disorder was observed except for a slight increase of biliary enzymes. The lesion was diagnosed as liver sarcoidosis by the liver biopsy. Since the patient refused steroid therapy, we prescribed ursodeoxycholic acid (UDCA). 600mg/day. The serum levels of biliary enzymes were normalized and the abdominal CT findings gradually improved after the initiation of UDCA medication. Gd-EOB MRI showed unique hypointense areas in the liver at the hepatobiliary phase, which might be useful in the diagnosis of liver sarcoidosis