Sublingual asenapine for agitation in malabsorptive states: three patient cases

Gastric malabsorptive conditions may prevent patients from deriving benefit from orally administered medications intended for enteric absorption. While malabsorption is an increasingly common issue, current data on alternative oral options for agitation in these patients are very sparse. Sublingual (SL) asenapine is absorbed transmucosally, bypassing gut absorption, making it a viable consideration. We report on three patients, one with short bowel syndrome, one with viral gastritis, and one with aortic dissection who were trialed on SL asenapine for agitation after failing alternative antipsychotics. Two of these patients had an extensive history of psychiatric admissions for bipolar disorder and substance-induced psychosis. All three patients had significant reductions in agitation within 1–5 days, with no reported adverse effects. However, benefit of SL asenapine was hindered in two of these patients as they began inappropriately swallowing the medication, reducing bioavailability to nil. Clinicians should consider the use of SL asenapine for medically complex agitated patients where gastric absorption is questionable. There is an urgent need for guidelines on this matter, as well as more, alternative dosage forms for various medications that may help with agitation in this population

Open Bibliography for Science, Technology, and Medicine

The concept of Open Bibliography in science, technology and medicine (STM) is introduced as a combination of Open Source tools, Open specifications and Open bibliographic data. An Openly searchable and navigable network of bibliographic information and associated knowledge representations, a Bibliographic Knowledge Network, across all branches of Science, Technology and Medicine, has been designed and initiated. For this large scale endeavour, the engagement and cooperation of the multiple stakeholders in STM publishing - authors, librarians, publishers and administrators - is sought. BibJSON, a simple structured text data format (informed by BibTex, Dublin Core, PRISM and JSON) suitable for both serialisation and storage of large quantities of bibliographic data is presented. BibJSON, and companion bibliographic software systems BibServer and OpenBiblio promote the quantity and quality of Openly available bibliographic data, and encourage the development of improved algorithms and services for processing the wealth of information and knowledge embedded in bibliographic data across all fields of scholarship. Major providers of bibliographic information have joined in promoting the concept of Open Bibliography and in working together to create prototype nodes for the Bibliographic Knowledge Network. These contributions include large-scale content from PubMed and ArXiv, data available from Open Access publishers, and bibliographic collections generated by the members of the project. The concept of a distributed bibliography (BibSoup) is explored

Open bibliography for science, technology, and medicine

The concept of Open Bibliography in science, technology and medicine (STM) is introduced as a combination of Open Source tools, Open specifications and Open bibliographic data. An Openly searchable and navigable network of bibliographic information and associated knowledge representations, a Bibliographic Knowledge Network, across all branches of Science, Technology and Medicine, has been designed and initiated. For this large scale endeavour, the engagement and cooperation of the multiple stakeholders in STM publishing - authors, librarians, publishers and administrators - is sought