FRAKSI ETANOL EKSTRAK KULIT DURIAN (Durio zibethinus L.) SEBAGAI ANTIFUNGI TERHADAP Trichophyton mentagrophytes DAN Candida albicans

Durian is a fruit that is in demand by the community, but during durian season environmental problems arise due to waste from skin of durian. The aimed of the study was to prove the antifungal activity of the ethanol fraction of durian skin against Trichophyton mentagrophytes and Candida albicans and to determine the active active compounds inhibiting T. mentagrophytes and C. albicans fungi. Durian skin was extracted by maceration method, then fractionated used ethanol, chloroform, and n-hexane solvents. Ethanol fraction was tested on T. mentagrophytes and C. albicans fungi used the disc method with a concentration of 10%, 20%, 40%, 60%, 80%, 100%, distilled water as a negative control, ketoconazole as a positive control. The best inhibition zone is fungi T. mentagrophytes concentration 100% ( 9.23 mm) negative control (0 mm), positive control (32.96 mm), fungi C. albicans the best inhibition zone is concentration of 100% (8.30 mm), positive control (17.17 mm) negative controls (0 mm).The ethanol fraction was screened by the Thin Layer Chromatography method and positively contained flavonoids (rf 0.7), tannins (rf 0.58), saponins (rf 0.76) and alkaloids (rf 0.64). Minimum Inhibitory Concentrations of T. mentagrophytes were 7% and C. albicans were 8%. The most effective active compound growht of T. mentagrophytes is tannins (rf 0.7) and for C. albicans is flavonoid (rf 0.6). The ethanol fraction of durian bark extract has antifungal activity against T. mentagrophytes and C. albicans. Keywords: Antifungi, Candida albicans, ethanol fraction skin of durian, Trichophytonmentagrophyte

PENDAMPINGAN PENGGUNAAN RAMUAN HERBAL UNTUK TELUR ASIN RENDAH KOLESTEROL SEBAGAI UPAYA PENINGKATAN PENDAPATAN “AMEER DUCK”

Teknologi pengolahan telur merupakan usaha untuk mengawetkan, memperpanjang daya simpan, dan mencegah penurunan kualitas telur. Pengolahan telur dapat meningkatkan pendapatan keluarga karena dapat dilakukan dalam skala rumah tangga dan dapat menjadi usaha bagi masyarakat yang hidup dipedesaan. Salah satu cara yang dapat dikembangkan adalah menerapkan teknologi pengolahan telur asin. Kandungan garam dan lemak yang tinggi di dalam telur asin  dapat meningkatkan kolesterol dalam darah, menyebabkan hipertensi, sehingga meningkatkan risiko terkena penyakit jantung, stroke, dan penyakit ginjal sehingga konsumsi untuk para orang tua dan lansia perlu dibatasi. Upaya mengatasi hal tersebut perlu upaya inovasi dalam pembuatan telur asin dengan menggunakan ramuan herbal diantaranya menggunakan kayu secang, daun mahkota dewa, daun salam, daun jambu biji dan sereh yang sudah terbukti secara ilmiah dapat menurunkan kadar lemak dan kolesterol dalam darah. Tujuan pengabdian ini adalah memproduksi telur asin herbal yang rendah kolesterol, sehingga telur asin yang diproduksi lebih sehat dengan memanfaatkan tanaman-tanaman disekitar kita yang memiliki potensi sebagai penurun kolesterol serta menginspirasi para pengusaha telur asin untuk berinovasi agar produk yang dihasilkan dapat  disenangi konsumen. Solusi yang ditawarkan melalui pembinaan dan pelatihan untuk membuat diversifikasi produk sehingga mitra dapat menghasilkan produk yang lebih banyak macamnya melalui sentuhan teknologi yang aman dan praktis. Diversifikasi produk dilakukan dengan memanfaatkan tanaman herbal antara lain kayu secang, daun mahkota dewa, daun salam, daun jambu biji dan sereh. Kesimpulan dalam pengabdian ini adalah adanya inovasi pembuatan telur asin herbal mampu meningkatakan pendapatan dan kesehatan masyarakat

FRAKSI ETANOL EKSTRAK KULIT PISANG KEPOK KUNING ( Musa balbisiana) TERHADAP BAKTERI Staphylococcus epidermidis, Staphylococcus aureus, dan Propionibacterium acnes

Yellow kepok banana peel (Musa balbisiana) contains antibacterial compounds against S. epidermidis, S. aureus and P.acne. This study aims to proved the antibacterial activity of the yellow kepok banana peel extract fractionated using ethanol as a solvent against S.epidermidis, S.aureus and P.acne. The yellow kepok banana peel extraction process was carried out by maceration method with 70% ethanol followed by fractionation to obtain ethanol fraction. Antibacterial activity testing using nutrient agar (NA) media with wells method with a concentration of 25,000 ppm, 50,000 ppm, 100,000 ppm, aquadest as a negative control and clindamycin as a positive control. The phytochemical test of the ethanol fraction showed the content of alkaloids, flavonoids, saponins, tannins and quinones. The results of the inhibition zone diameter of the ethanol fraction at a concentration of 100,000 ppm against S. epidermidis (11.87 mm), S. aureus (12.04 mm) and P. acne (11.35 mm). The test is to determined the minimum inhibitory concentration (MIC) the minimum inhibitory concentration value of the ethanol fraction of S. epidermidis, S. aureus is 20,000 ppm and for P. acne is 17,500 ppm. The conclusion of this studied was that the ethanol fraction of kepok yellow banana peel extract has inhibitory and bacteriostatic properties against S. epidermidis, S. aureus and P.acne bacteria.Keywords: alkaloids,Ant ibacter ial , flavonoids , Fractionated, Musa balbisian

AKTIVITAS ANTIBAKTERI KOMBINASI EKSTRAK DAUN KEMANGI (Ocymum x africanum L.) DENGAN DAUN PEPAYA (Carica papaya L.) TERHADAP Staphylococcus aureus

Abstract  Infectious diseases are one of the diseases that have suffered by many Indonesian people for a long time. S. aureus bacteria is the cause of pyogenic infections. Basil plants (Ocymum x africanum L.) and papaya plants (Carica papaya L.) can be used as antibacterial. This study aims to determine the antibacterial activity of the combination of basil and papaya leaf extracts against S. aureus bacteria. Using the Experimental Method with a combination of extract concentrations, namely K1 (0+100%), K2 (20%+80%), K3 (40%+60%), K4 (50%+50%), K5 (60%+40% ), K6 (80%+20%), K7 (100%+0%), K(-) aquadest, K(+) Oxfloxacin, followed by a test for S. aureus bacteria using the well method. The test results were analyzed using One Way Annova. with sig value (0.000) < p-value (0.05) followed by Tukey's further test which showed the combination of concentrations showed significant differences between the test groups. From this explanation, it can be concluded that the combination of basil leaf extract and papaya leaf extract can increase the inhibition zone, the largest inhibition zone is in K4 (50% basil leaf extract + 50% papaya leaf extract) the inhibitory response that appears 19.69 mm belongs to the strong category. inhibit the growth of S. aureus bacteria.  Keywords: Antibacterial, basil leaf, papaya leaf, Staphylococcus aureus

FRAKSI ETANOL RIMPANG KENCUR (Kaempferia Galanga L.) SEBAGAI ANTIBAKTERI TERHADAP Bacillus Subtilis dan Escherichia coli

Abstract   People were accustomed to use natural ingredients as traditional medicine because it was more economical and has little bit side effects compared with synthetic drugs. One of the herbs that has been widely known in the community as traditional medicine was the kencur rhizome. The kencur rhizome contains flavonoid and saponins which were antibacterial. The purpose of this study was to prove that there was the inhibition in ethanol fraction of kencur rhizome towards the growth of bacillus subtilis and Escherichia coli. The extraction process of kencur rhizome was carried out by maceration method used 70% ethanol solvent and continued with fractionation by using ethanol, n-hexane and chloroform solvents. Then, antibacterial test used diffusion method with concentrations of 25%, 50%, 75%, 100%, positive control of ciprofloxacin and negative control of aquadest. The test was continued by looking at the formation of inhibition zones around the diffusion and measured by using a calipers. The highest diameter of inhibition zone antibacterial activity of kencur rhizome at concentration 100% with a diameter of 22.00 mm in E. Coli and 20.00 mm for B. Subtilis, whereas positive control diameter inhibition zone of ciproflocaxin was 40.00 mm in E. Coli and 40.0 in B. Subtilis. The conclusion of this study was the ethanol fraction of kencur rhizome 100% concentration is the best concentration in the inhibition zone. Keywords: Antibacterial, Bacillus Subtilis, Escherichia coli, Kencur

PENINGKATAN PRODUKSI DAN PEMASARAN PADA USAHA RISOL MELALUI DIGITAL MARKETING

Risol is a snack that has been known for so long. As a market snack, risol sold in the form of ready-to-eat already has a relatively stable market demand. Because risol is very popular from various circles, both ordinary people and office workers, for this reason, Nasi Goreng and Gorengan SMEs are also trying to develop their talents by opening a type of business "VEGETABLE RISOL" because many of these risols imitate being partners and continue to innovate. The main problems for partners are in terms of production, management and digital marke ting. The purpose of the service activity is to increase the production and income of partners through sales promotions and implement science and technology to inspire market snack consumers to always innovate so that their products are liked by consumers. Solutions and targets by providing production support equipment needs, increasing skills, counseling on marketing strategies and simple bookkeeping as well as simulating trademark labeling and developing social media for sales promotion. The results and discussion of activities that have an important impact on the community and benefit all parties directly involved in service activities. Keywords: Digital Marketing, Production, Vegetable Riso

AKTIVITAS ANTIPIRETIK KOMBINASI EKSTRAK ETANOLMENIRAN (Phyllanthus niruriL) DAN DAUN BELIMBING WULUH (Avverhoabillimbi) PADA TIKUS PUTIH JANTAN YANG DIINDUKSI VAKSIN DPT-Hb

Abstract Fever is defined as a change in the body's temperature regulation mechanism which results in an increase in body temperature above normal above 32.7ºC. Antipyretics are drugs used to reduce fever, one of which is paracetamol, but the use of paracetamol in large doses and for a long time has the potential to cause damage to the kidneys, brain, liver (hepatotoxic), disorders of the digestive system, respiratory system and hematological effects. These unwanted effects can be minimized using the active ingredients of meniran (Phylantus niruri L) and wuluh (Avverhoa bilimbi) plants. The purpose of this study was to prove the antipyretic activity of the combination of meniran leaf extract (Phylantus niruri L) and wuluh starfruit leaf (Avverhoa bilimbi) in male white rats (Rattus norvegicus L) induced by the DPT-Hb vaccine. The principle of this research is laboratory experimental research. This study included a combination of samples of meniran leaves and starfruit leaves, making thick extracts of meniran leaves and starfruit leaves, and testing the effect of antipyretics on the test animals. This study used the DPT–Hb (fever) vaccine induction method and the SPSS analysis method. The results showed that ethanol extract of meniran leaves 200mg/200grBB, ethanol extract of belimbing wuluh leaves 7.2mg/200grBB and a combination of ethanolic extract of meniran leaves with starfruit at doses of 200mg/200grBB and 7.2mg/200grBB, 100mg/200grBB and 3.6mg/ 200grBW, 200mg/200grBW and 3.6mg/200grBW, 100mg/200grBW, and 7.2mg/200grBW had antipyretic effects on male white rats.  Keywords: antipyretic, starfruit, menira

PENGARUH PERAN FARMASIS TERHADAP PENGETAHUAN PASIEN TENTANG PENATALAKSANAAN PENYAKIT DIARE DI PUSKESMAS RAWAT INAP SUKARAJA KOTA BANDAR LAMPUNG

Diarrheal disease in developing countries like Indonesia is still a public health problem that can cause child death in the world. Diarrhea is a condition characterized by a person having loose stools three or more times a day. This case of diarrhea needs the role of pharmacists such as education to increase patient knowledge about the management of diarrheal diseases. Education is an activity to increase individual health knowledge regarding the management of risk factors for disease and healthy living behavior in an effort to improve public health status, prevent recurrence of disease and recover from disease. Factors that influence a knowledge that is age, education, occupation and sources of information. This study aims to determine whether there is a relationship between education and the level of patient knowledge about the management of diarrheal diseases at the Sukaraja Inpatient Health Center, Bandar Lampung City. This research is a non-experimental research with an observational analytic research design, using a one group pre-test and post-test study design that can be analyzed using the Statistical Product and Service Solutions (SPSS) method. This study was conducted for 2 months with the results of the study showing the characteristics of patients based on age, the most were 26-45 years old with 19 people (47.5%), high school education as many as 20 people (50%), and the most type of work was housewives 17 people (42.5%). The level of patient knowledge after being given an education can be seen from the Wilcoxon test with a significant value <0.005, stating that there is a relationship between education and the level of patient knowledge about the management of diarrheal diseases at the Sukaraja Inpatient Health Center, Bandar Lampung. Keywords: Diarrhea, Education, Knowledge Level

EKSTRAK DAUN KATUK (Sauropus androgynus (L) Merr) SEBAGAI ANTIBAKTERI TERHADAP Propionibacterium acnes dan Staphylococcus epidermidis

Katuk is one of the most common plant species in Indonesia which is known by the community to treat the disease, especially the leaf part can be used as a milk mat. katuk leaf (Sauropus androgynus (L) Merr) also contains saponin, flavonoid and tannin Inhibits the growth of bacteria one of the bacteria that cause acne bacteria P. acnes and S. epidermidis. The aim of this research is to know the antibacterial inhibition effect of katuk leaf extract to growth of P. acnes and S. epidermidis using Cup-plate or pit diffusion method with concentration 20%, 40%, 60%, 80% and 100%. Clindamycin is used as a positive control and aquades as a negative control. The leaves of katuk extracted with 70% ethanol solvent showed no antibacterial activity against P. acnes bacteria while against S. epidermidis bacteria showed antibacterial activity. The highest antibacterial activity at 100% concentration with 18.17 mm zone diameter belong to the category of inhibitory resistance of medium growth and the lowest concentration at concentration of 40% with 16.68 mm inhibitory zone diameter belong to the weak growth inhibitory response category. The minimum inhibitory concentrations produced in S. epidermidis bacteria were 39% - 36%. Keywords : Sauropus androgynus, Propionibacterium acnes, Staphilococcus epidermidis, Minimal Inhibitory Concentration

AKTIVITAS ANTIBAKTERI KOMBINASI EKSTRAK DAUN JAMBU BIJI (Psidium guajava L.)DENGAN DAUN SIRSAK ( Annona muricata L.) TERHADAP Escherichia coli

Infection is a type of disease that is often found in developing countries, including Indonesia. Escherichia coli is one of the most common causes of infection in society. The most common clinical symptoms in cases of this infection include watery diarrhea, abdominal cramps, low-grade fever, nausea, and malaise. Guava plants (Psidium guajava L.) and soursop plants (Annona muricata L.) are medicinal plants that are easy to find in Indonesia. Guava leaves and soursop leaves can be used as antibacterials. This study aims to determine the antibacterial activity of a combination of guava leaf extract (Psidium guajava L.) and soursop leaves (Annona muricata L.) against Escherichia coli bacteria. The method used is an experimental method of combining the concentrations of guava leaf extract and soursop leaves, namely K1 (100% + 0%), K2 (80% + 20%), K3 (60% + 40%), K4 (50% + 50% ), K5 (40%+60%), K6 (20%+80%), K7 (0%+100%), K(-) aquadest, K(+) Ciprofloxacin which was then followed by testing for Escherichia coli bacteria using the hole or well method. The variable measured in this study was the diameter of the inhibition zone formed in the combination of extracts. The results of observations were analyzed using One Way Annova with a sig value (0.000) <p value (0.050) followed by a follow-up tukey test which showed K1, K2, K3, K4, K5, K6, K7, K(-) and K(+) real different. It can be concluded from this study that the largest inhibition zone of combined extracts was found in K2 (80% guava leaf extract + 20% soursop leaf extract) with an average inhibition zone of 11.89 mm which belonged to the strong category. Inhibits the growth of E.coli bacteria. Keywords : guava leaves, soursop leaves, Escherichia coli, inhibition zon