Predictability of verapamil steady‐state plasma levels from single‐dose data explained

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/109880/1/cptclpt1984129.pd

A safe method for rapidly achieving plasma concentration plateaus

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/116931/1/cpt1974164691.pd

Ionic Capillary Evaporation in Weakly Charged Nanopores

Using a variational field theory, we show that an electrolyte confined to a neutral cylindrical nanopore traversing a low dielectric membrane exhibits a first-order ionic liquid-vapor pseudo-phase-transition from an ionic-penetration "liquid" phase to an ionic-exclusion "vapor" phase, controlled by nanopore-modified ionic correlations and dielectric repulsion. For weakly charged nanopores, this pseudotransition survives and may shed light on the mechanism behind the rapid switching of nanopore conductivity observed in experiments.Comment: This version is accepted for publication in PR

Prediction of steady‐state verapamil plasma concentrations in children and adults

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/110108/1/cptclpt1982144.pd

X-Ray Spectral Variability of PKS 2005-489 During the Spectacular November 1998 Flare

We report on monitoring of the BL Lac object PKS 2005-489 by the Rossi X-ray Timing Explorer (RXTE) in October-December 1998. During these months, the source underwent a spectacular flare; at its peak on November 10, its 2-10 keV flux was $3.33 \times 10^{-10} {\rm ~erg ~cm^{-2} ~s^{-1}}$, over 30 times brighter than in quiescence. During the rising phase, the X-ray spectrum of PKS 2005-489 hardened considerably, reaching $\alpha = 1.32~ (F_\nu \propto \nu^{-\alpha})$ near maximum. During the declining phase, the X-ray spectrum steepened rapidly, reaching $\alpha = 1.82$, then became somewhat harder towards the end of December ($\alpha \sim 1.6$). While such behavior has been seen before, the simplicity, magnitude and duration of this flare allowed us to study it in great detail. We argue that this flare was caused by either the injection of particles into the jet or {\it in situ} particle acceleration, and that the spectral steepening which followed the flare maximum was the result of synchrotron cooling. Contrary to other recently observed blazar flares (e.g., Mkn 501, 3C 279, PKS 2155-304), our results do not imply a major shift in the location of the synchrotron peak during this flare.Comment: ApJ Letters in press, 6 pages, 2 figures Corrected reference

An adjudicated hermeneutic single-case efficacy design study of experiential therapy for panic/phobia

This paper illustrates the application of an adjudicated form of Hermeneutic Single Case Efficacy Design (HSCED), a critical-reflective method for inferring change and therapeutic influence in single therapy cases. The client was a 61 year-old European-American male diagnosed with panic and bridge phobia. He was seen for 23 sessions of individual Process-Experiential/Emotion-Focused Therapy. In this study, affirmative and skeptic teams of researchers developed opposing arguments regarding whether the client changed over therapy and whether therapy was responsible for these changes. Three judges representing different theoretical orientations then assessed data and arguments, rendering judgments in favor of the affirmative side. We discuss clinical implications and recommendations for the future interpretive case study research

Do you need a pharmacokinetic model, and, if so, which one?

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/45062/1/10928_2005_Article_BF01059477.pd