A NEW TRANSDERMAL SYSTEM I.

With the aim of developing a new drug delivery system, the transdermal therapeutic system (TTS), the author has studied membranes prepared from polydimethylsiloxane-α, ω-diols with different viscosities. The solvent uptake of the membranes was studied using solvents of different polarities. The results of thermochemical investigations supported the differences found in the behaviour of the membranes

SILA-PHARMACA. II STRUCTURE OF METHYL-IODIDE SALTS OF DIMETHYLPHENYLPIPERIDINOMETHYLSILANE AND N-(,6-PHENYLETHYL)PIPERIDINE

X-ray structures of the methyliodide salts of (N-(,B-phenylethyl)piperidine (N-(,B-phenyl- ethyl )-N-methyl-piperidiniumiodide) and dimethylphenyl-piperidinomethyl-silane (N- methyl-N-(phenyldimethylsilyl )-methyl- piperidinium iodide) are reported

STUDIES ON BIOACTIVE ORGANO-SILICON COMPOUNDS

The activity of the research group for biologically active organosilicon compounds is de- scribed in the paper. The group is concerned with the investigation of silatranes and their derivatives, N,N'-diarylcyclodisilazanes, silaarylalkylamines. The compounds were synthesized and studied by X-ray diffraction and different spectroscopic techniques

Nagyrugalmasságú anyagokból készült szenzorok és pneumatikus/hidraulikus működtetésű aktuátorok = Hydraulic actuators made from high elasticity material for mechanical engineering and for the medicine

A nagyrugalmasságú szerkezetekben alkalmazható szilikon gumi típusok mechanikai, dinamikai, villamos, optikai tulajdonságainak rendszerező, és élettartam vizsgálatait végeztük el. Kimutattuk, hogy mely anyagtípusoknál helyettesíthetők a nagy tisztaságú, drága orvosi szilikonok olcsóbb ipari típusokkal. Megmutattuk, hogy a prototípus gyártás területén szokásos két technológiával előállított szilikon gumi fontos mechanikai tulajdonságai között nincs meghatározó különbség. Az új, pneumatikus aktuátoros, digitális vezérlésű, testüreg-szonda ipari és orvosi alkalmazásra alkalmas. A gyógyászat területén nagy a mesterséges sphincter (bélelzáró) bionikai prototípusa, amely alapvetően eltér az ismert megoldástól. Az alakoptimalizálás fázisában van a minimál-invazív sebészethez nélkülözhetetlen védőcső és aktuátor. Igazoltuk a nagytisztaságú optikai szilikon kettőstörő tulajdonságát, és elsőként alkalmaztuk az effektust erőmérőben. A vezető szilikon gumi szenzor nagyrugalmasságú anyagokból készült, és iparban alkalmazott szerkezetekhez való integrálhatóságát vizsgáltuk eredményesen. Modellkísérleteink szerint a szenzor versenylovak minimál-invazív mozgásanalízisére is alkalmas. Kidolgoztuk a mágnesek szilikonnal való bevonását bélfalakon átvezető nyílások létrehozására varratkészítés nélkül, a módszer jelenleg állatkísérleti fázisban van. Elkészült a kézsebészeti az ín-pótlás céljára kifejlesztett szilikon eszköz. Készült újszerű nyelőcső stent is. Műtéti segédeszközöket készítettünk és fejlesztünk folyamatosan, a legújabb sebészeti technikához (NOTES). | Mechanical, dynamical, electric and optic properties and the durability of diverse silicone rubber types applicable in high elastic systems have been investigated and compared. We showed which types of expensive medical rubbers can be substituted by industrial types. We showed that no significant differences of the mechanical properties exist between products manufactured with the two typical prototype technologies. The new type pneumatic controlled intestinal robot is usable in the medicine and in the industry as well. The prototype of the new bionic based artificial sphincter is important for the medicine. The ?overtube? with special actuator is necessary for the minimal invasive surgery. We verified the existence of the double diffraction of the pure optical silicone rubber and used this effect in force transducer. The integration of conductive silicone rubber on high elasticity industrial structures was showed. Our model experiments show that this sensor can be used successfully for the movement analysis of race horses. We developed the technology of silicone rubber covering of permanent magnets used in minimal intensive surgery for the creation of gastro-entero anastomosis. A new type of artificial tendon for the acute hand surgery and a special oesophag (gullet) stent were developed. New high flexible instruments and helps were created for the use in the newest minimal intensive surgery named NOTES

Development of Capsaicin-Containing Analgesic Silicone-Based Transdermal Patches

Transdermal therapeutic systems (TTSs) enable convenient dosing in drug therapy. Modified silicone-polymer-based patches are well-controlled and cost-effective matrix diffusion systems. In the present study, we investigated the substance release properties, skin penetration, and analgesic effect of this type of TTS loaded with low-dose capsaicin. Release properties were measured in Franz diffusion cell and continuous flow-through cell approaches. Capsaicin was detected with HPLC-UV and UV spectrophotometry. Raman spectroscopy was conducted on human skin samples exposed to the TTS. A surgical incision or carrageenan injection was performed on one hind paw of male Wistar rats. TTSs were applied to the epilated dorsal skin. Patches were kept on the animals for 6 h. The thermal hyperalgesia and mechanical pain threshold of the hind paws were detected. Patches exhibited controlled, zero-order kinetic capsaicin release. According to the Raman mapping, capsaicin penetrated into the epidermis and dermis of human skin, where the target receptors are expressed. The thermal pain threshold drop of the operated rat paws was reversed by capsaicin treatment compared to that of animals treated with control patches. It was concluded that our modified silicone-polymer-based capsaicin-containing TTS is suitable for the relief of traumatic and inflammatory pain