Synthesis of enantiomerically enriched benzimidazole-triazoles: Application as organocatalyst for asymmertric Diels-Alder reaction

93-1014-(Benzimidazolylmethyl)-1,2,3-triazole derivatives 8a-g and 9a-g have been developed using click chemistry protocol in regioselective manner and in high yields. These compounds have geometry to behave as chiral tweezers due to the presence of flexibly bound pi-rich hetero-aryl rings in addition to a chiral center. The synthesized chiral benzimidazole-triazoles have been found to be useful as organocatalysts for the enantioselective Diels-Alder (DA) reaction between anthrone 10 and maleimide detivatives 11a-g. Enantioselectivity levels have been found to be dependent on several factors including nature of substituents in benzimidazole-triazoles 8a-g and 9a-g

Blind docking of 4-Amino-7-Chloroquinoline analogs as potential dengue virus protease inhibitor using CB Dock a web server

Currently, there is no approved drug to combat dengue. Various quinoline derivatives are known for potential antimalarial, antiviral activities, etc. In the present work docking between 4-Amino-7-Chloroquinoline analogs was performed with dengue virus NS2B/NS3 protease using CB dock, a web server. Lys74, Ile165, Val147, Asn152, Asn167, Trp83 and Leu149 amino acid residues were found to be in contact with designed 4-Amino-7-Chloroquinoline analogs. Different modes of binding like hydrogen bonding, hydrophobic interactions, etc with designed compounds improve potential anti-dengue characteristics in silico. ADME results are in acceptable range

A convenient route to benzimidazole fused chiral heterocyclic bases

707-712<span style="font-size:11.0pt;font-family: " times="" new="" roman","serif";mso-fareast-font-family:"times="" roman";mso-bidi-font-family:="" mangal;mso-ansi-language:en-gb;mso-fareast-language:en-us;mso-bidi-language:="" hi"="" lang="EN-GB">An efficient synthetic protocol has been developed to obtain new chiral heterocyclic bases pyrrolo-benzimidazoles (DHP-Bz) and thiazolo-benzimidazoles (DHT-Bz). Notable characteristic of both series of the fused heterocycles is the presence of a chiral center. Chiral HPLC separations of the fused heterocycles have been achieved. These molecules possess structural features well-suited to function as chiral organocatalysts after resolution, apart from potential biological activities.</span

Blind docking of 4-Amino-7-Chloroquinoline analogs as potential dengue virus protease inhibitor using CB Dock a web server

55-57Currently, there is no approved drug to combat dengue. Various quinoline derivatives are known for potential antimalarial, antiviral activities, etc. In the present work docking between 4-Amino-7-Chloroquinoline analogs was performed with dengue virus NS2B/NS3 protease using CB dock, a web server. Lys74, Ile165, Val147, Asn152, Asn167, Trp83 and Leu149 amino acid residues were found to be in contact with designed 4-Amino-7-Chloroquinoline analogs. Different modes of binding like hydrogen bonding, hydrophobic interactions, etc with designed compounds improve potential anti-dengue characteristics in silico. ADME results are in acceptable range

Synthesis of cholest-5-en-3-ol(3β)-3-[4-(2,2,2-trifluoroacetamido) benzoate] (ChTfAB) a thermotropic liquid crystalline material

755-760The synthesis of cholest-5-en-3-ol(3β)-3-[4-(2,2,2-trifluoroacetamido)benzoate] (ChTfAB) is carried out by esterification of cholesterol and p-nitrobenzoic acid using DCC, DMAP, followed by reduction of nitro group using SnCl2. The so formed amino group is further N-acylated using trifluoroacetic anhydride. The newly synthesized compound is characterized using IR and 1H NMR spectroscopic techniques. Its mesomorphic properties have been investigated using Differential Scanning Colorimetry (DSC) and Polarising Optical Microscopy (POM). The thermal and phase behaviour studies reveal the synthesized compound to be an enantiotropic, thermotropic liquid crystal. This synthesized compound overcomes the problem of degrading at the melting temperature associated with one of the previously synthesized and reported steroidal compound