5 research outputs found
Synthesis of enantiomerically enriched benzimidazole-triazoles: Application as organocatalyst for asymmertric Diels-Alder reaction
93-1014-(Benzimidazolylmethyl)-1,2,3-triazole derivatives 8a-g and 9a-g have been developed using click chemistry protocol in regioselective manner and in high yields. These compounds have geometry to behave as chiral tweezers due to the presence of flexibly bound pi-rich hetero-aryl rings in addition to a chiral center. The synthesized chiral benzimidazole-triazoles have been found to be useful as organocatalysts for the enantioselective Diels-Alder (DA) reaction between anthrone 10 and maleimide detivatives 11a-g. Enantioselectivity levels have been found to be dependent on several factors including nature of substituents in benzimidazole-triazoles 8a-g and 9a-g
Blind docking of 4-Amino-7-Chloroquinoline analogs as potential dengue virus protease inhibitor using CB Dock a web server
Currently, there is no approved drug to combat dengue. Various quinoline derivatives are known for potential antimalarial, antiviral activities, etc. In the present work docking between 4-Amino-7-Chloroquinoline analogs was performed with dengue virus NS2B/NS3 protease using CB dock, a web server. Lys74, Ile165, Val147, Asn152, Asn167, Trp83 and Leu149 amino acid residues were found to be in contact with designed 4-Amino-7-Chloroquinoline analogs. Different modes of binding like hydrogen bonding, hydrophobic interactions, etc with designed compounds improve potential anti-dengue characteristics in silico. ADME results are in acceptable range
A convenient route to benzimidazole fused chiral heterocyclic bases
707-712<span style="font-size:11.0pt;font-family:
" times="" new="" roman","serif";mso-fareast-font-family:"times="" roman";mso-bidi-font-family:="" mangal;mso-ansi-language:en-gb;mso-fareast-language:en-us;mso-bidi-language:="" hi"="" lang="EN-GB">An efficient synthetic protocol has been developed to obtain new chiral heterocyclic
bases pyrrolo-benzimidazoles (DHP-Bz)
and thiazolo-benzimidazoles (DHT-Bz). Notable characteristic of both series
of the fused heterocycles is the presence of a chiral center. Chiral HPLC separations
of the fused heterocycles have been achieved. These molecules possess structural
features well-suited to function as chiral organocatalysts after resolution, apart
from potential biological activities.</span
Blind docking of 4-Amino-7-Chloroquinoline analogs as potential dengue virus protease inhibitor using CB Dock a web server
55-57Currently, there is no approved drug to combat dengue. Various quinoline derivatives are known for potential
antimalarial, antiviral activities, etc. In the present work docking between 4-Amino-7-Chloroquinoline analogs was
performed with dengue virus NS2B/NS3 protease using CB dock, a web server. Lys74, Ile165, Val147, Asn152, Asn167,
Trp83 and Leu149 amino acid residues were found to be in contact with designed 4-Amino-7-Chloroquinoline analogs.
Different modes of binding like hydrogen bonding, hydrophobic interactions, etc with designed compounds improve
potential anti-dengue characteristics in silico. ADME results are in acceptable range
Synthesis of cholest-5-en-3-ol(3β)-3-[4-(2,2,2-trifluoroacetamido) benzoate] (ChTfAB) a thermotropic liquid crystalline material
755-760The synthesis of cholest-5-en-3-ol(3β)-3-[4-(2,2,2-trifluoroacetamido)benzoate] (ChTfAB) is carried out by esterification
of cholesterol and p-nitrobenzoic acid using DCC, DMAP, followed by reduction of nitro group using SnCl2. The so formed
amino group is further N-acylated using trifluoroacetic anhydride. The newly synthesized compound is characterized using
IR and 1H NMR spectroscopic techniques. Its mesomorphic properties have been investigated using Differential Scanning
Colorimetry (DSC) and Polarising Optical Microscopy (POM). The thermal and phase behaviour studies reveal the
synthesized compound to be an enantiotropic, thermotropic liquid crystal. This synthesized compound overcomes the
problem of degrading at the melting temperature associated with one of the previously synthesized and reported steroidal
compound