Universal Mobile Application Development (UMAD) On Home Automation

At present scenario the market is flooded with many cell phones compatibility issues intended with Operating System and hardware's, so the applications are not made in a manner to suite large mass. Till now the applications made were targeted to a particular Operating System only which restricted there usability. With the limitations of above in mind there is a need of a universal mobile application development (UMAD) platform. So that an application can be developed in a universal XML format which can be easily ported to any other mobile devices.  This paper presents the design and implementation of the Home automation system on one of the Operating System and creation of a unique XML document that can be placed over the server which can be adapted by any other mobile device without any platform issues. The XML format which controls the layout of the screen remains common, only the part which needs to be coded on every platform is the downloading of the XML file from the server and parsing it. This reduces a lot of coding effort as the design part is coded only once, and the same file can be used by every other platform. We have taken Home Automation system as our application, in which all the household devices such as Bulb, Fan, AC etc. all are controlled by a smartphone which is connected to a server containing the XML file via an internet connection. Every change made by the user on the smartphone affects the data in the XML file of server, which thus helps in continuous updating of data and all other users get an updated Graphical User Interface. We have taken Home Automation as one of our application, but the same principle can be implemented in any other applications like Mobile Themes, Games etc. Keywords: Android, Hardware Modulator, Home Automation, iOS, UMAD, Universal Mobile Application, XML

INHIBITION OF α-AMYLASE AND α-GLUCOSIDASE BY (6RS)-22-HYDROXY-23,24,25,26,27-PENTANOR-VITAMIN-D3-6,19-SULFUR DIOXIDE-ADDUCT, MANOALIDE AND 5β-CHOLESTANE-3α,7α,12α,24,25,26-HEXOL ISOLATED FROM ACETONE EXTRACT OF HELIANTHUS ANNUUS L. SEEDS

Objective: This investigation includes characterization of phytochemicals from acetone extract of Helianthus annuus L. seeds responsible for α-amylase and α-glucosidase inhibition revealed from in vitroand in silico approaches. Methods: Seed extract was qualitatively and quantitatively analysed for the presence of bioactive molecules. In vitro α-amylase and α-glucosidase inhibition assays and kinetics studies for α-glucosidase were done. Thin layer chromatography (TLC) autography of extract was done to screen potent inhibitors and characterized by high-resolution liquid chromatography-mass spectrometry (HR LC-MS). Characterized molecules were further used for in silico studies. Results: Qualitative investigation reveals the presence of flavonoids, glycosides, alkaloids, terpenoids, and steroids. Quantitative analysis for total phenolic content and total flavonoid content of the extract was 0.1±0.005 mg/ml GAE and 0.025±0.003 mg/ml QE respectively. Percent inhibition of α-amylase and α-glucosidase ascertained in presence of extract was 60.42±0.6 and 83.22±0.18 at 0.01 mg while 36.24±0.81 and 37.67±0.15 at 0.005 mg of extracts for both enzymes respectively. Kinetics studies of α-glucosidase inhibition illustrated the non-competitive type of inhibition. TLC autography inhibition patterns were characterized by HR LC-MS. Characterized molecules on docking revealed (6RS)-22-hydroxy-23,24,25,26,27-pentanor-vitamin-D3-6,19-sulfurdioxide-adduct, manoalide and 5β-cholestane-3α,7α,12α,24,25,26-hexol as the best docked molecules with lowest binding energies of-12.5,-11 and-10.2 kcal/mol for α-amylase and-14.2,-11 and-11.2 kcal/mol for α-glucosidase respectively. Conclusion: Results clearly suggested that (6RS)-22-hydroxy-23,24,25,26,27-pentanor-vitamin-D3-6,19-sulfurdioxide-adduct, manoalide and 5β-cholestane-3α,7α,12α,24,25,26-hexol could be considered as lead molecules for the discovery of potent antidiabetic agents

A Bird view on Heat Transfer Enhancement in a Tube with Twisted Tape Insert

Different kinds of methods used to enhance heat transfer rate of heat exchanger without influencing overall performance of the heat exchanger referred as heat transfer enhancement techniques. This technique are categorized into three types i.e. active technique, passive technique, and compound technique Some of the application of heat exchanger which require enhancement in heat transfer are – Air conditioning equipments, radiators, refrigerators, thermal Power plants etc. The intention of enhanced heat transfer is to encourage high heat fluxes, this result in reduction in size of heat exchanger. The present paper is a review of research work in last decade on heat transfer enhancement in a Heat Exchanger DOI: 10.17762/ijritcc2321-8169.15037

A prospective study on association of migraine with tension-headache: Is neck pain a common burden in India?

Background. The present study aimed to know the association and causal relationship of neck pain with different primary and mixed-type headache disorders. Material and methods. The primary patients with headaches attending the Department of Neurology OPD throughout one-year were included in the study. The demographic features, detailed history of headaches, and the characteristics of neck pain were entered in the pre-designed proforma. With the collaboration of the Department of Neurology, All India Institute of Medical Sciences, Jodhpur, Department of Neurology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow and the Department of Neurology, IMS and SUM Hospital, Bhubaneswar, India. Results. A total of 601 primary headache patients were included in the study, among which a fraction of 66.4% (n=399) had the problem of neck pain either as a pre-disposing event or as a part of the headache. Females were predominately higher than males with a fraction of 67.6%. Among all the patients a fraction of 21% (n=84) had a migraine, 51% (n=203) had a tension-type headache (TTH) and 28% (n=112) had a mixed-type headache. Though several patients with migraine had neck pain as a part of migraine, neck pain was significantly associated with tension and mixed type headache than migraine headache (p<0.001 vs p=0.35). Among the mixed-quality of headaches; chronic TTH (CTTH) with episodic migraine (EM) was most common (54.5%, n=61), followed by CTTH with chronic migraine (CM) at 33% (n=37). Conclusion. The presence of neck pain in migraine headaches showed an increased association with TTH whereas the reverse may not be true. This is yet to prove whether this is a mere association or a causal relationship

3D-QSAR of histone deacetylase inhibitors as anticancer agents by genetic function approximation

360-371Histone deacetylases (HDACs) playa critical role in gene transcription and are implicated in cancer therapy and other diseases. Inhibitors of HDACs induce cell differentiation and suppress cell proliferation in the tumor cells. Although many such inhibitors have been designed and synthesized, but selective inhibitors for HDAC isoforms are lacking. Various hydroxamic acid analogues have been reported as HDAC inhibitors. Here, we report a three-dimensional quantitative structure-activity relationship (3D-QSAR) study performed using genetic function approximation (GFA) for this class of molecules. QSAR models were generated using a training set of 39 molecules and the predictive ability of final model was assessed using a test set of 17 molecules. The internal consistency of the final QSAR model was 0.712 and showed good external predictivity of 0.585. The results of the present QSAR study indicated that molecular shape analysis (MSA), thermodynamic and structural descriptors are important for inhibition of HDACs. </span

The evaluation of weekly extended range river basin rainfall forecasts and a new bias correction mechanism for flood management in India

Operational extended range forecasts are being disseminated once every week by the India Meteorological Department (IMD) for several sectorial applications. These forecasts show a reduction in amplitude and variance as a function of lead-time. Such reductions in variance can be due to several physical factors: inherent forecast model bias, a problem relating to initial conditions, leaddependent statistical biases, etc. A week-by-week analysis shows that such biases are not systematic. Rainfall forecasts are underestimated in some regions, while others overestimate rainfall amplitude. To correct the bias in the extended range weekly averaged forecast, a statistical post-processing method (normal ratio correction) is proposed to make the outlook more valuable at a longer lead-time. The correction method is based on the World Meteorological Organization (WMO) technical guidance on rainfall estimation and is also shown to be useful for rainfall forecasts. In this analysis, we evaluate the extended range forecast skill at the river sub-basin-scale and show that there are several river sub-basins over the central Indian region where the correction has improved the model forecast in the one to two-week range. Although this analysis was tailored toward making the river basins and sub-basins of India more readily realizable for flood forecasters, it can be used for any administrative boundaries such as block, district, or state-level requirements