Digital Signal Processing Research Program

Contains table of contents for Section 2, an introduction, reports on twenty-one research projects and a list of publications.U.S. Navy - Office of Naval Research Grant N00014-93-1-0686Lockheed Sanders, Inc. Contract P.O. BY5561U.S. Air Force - Office of Scientific Research Grant AFOSR 91-0034National Science Foundation Grant MIP 95-02885U.S. Navy - Office of Naval Research Grant N00014-95-1-0834MIT-WHOI Joint Graduate Program in Oceanographic EngineeringAT&T Laboratories Doctoral Support ProgramDefense Advanced Research Projects Agency/U.S. Navy - Office of Naval Research Grant N00014-89-J-1489Lockheed Sanders/U.S. Navy - Office of Naval Research Grant N00014-91-C-0125U.S. Navy - Office of Naval Research Grant N00014-89-J-1489National Science Foundation Grant MIP 95-02885Defense Advanced Research Projects Agency/U.S. Navy Contract DAAH04-95-1-0473U.S. Navy - Office of Naval Research Grant N00014-91-J-1628University of California/Scripps Institute of Oceanography Contract 1003-73-5

Digital Signal Processing Research Program

Contains table of contents for Section 2, an introduction and reports on fourteen research projects.U.S. Navy - Office of Naval Research Grant N00014-91-J-1628Defense Advanced Research Projects Agency/U.S. Navy - Office of Naval Research Grant N00014-89-J-1489MIT - Woods Hole Oceanographic Institution Joint ProgramLockheed Sanders, Inc./U.S. Navy Office of Naval Research Contract N00014-91-C-0125U.S. Air Force - Office of Scientific Research Grant AFOSR-91-0034U.S. Navy - Office of Naval Research Grant N00014-91-J-1628AT&T Laboratories Doctoral Support ProgramNational Science Foundation Fellowshi

Entropic Forces Drive Clustering and Spatial Localization of Influenza A M2 During Viral Budding

The influenza A matrix 2 (M2) transmembrane protein facilitates virion release from the infected host cell. In particular, M2 plays a role in the induction of membrane curvature and/or in the scission process whereby the envelope is cut upon virion release. Here we show using coarse-grained computer simulations that various M2 assembly geometries emerge due to an entropic driving force, resulting in compact clusters or linearly extended aggregates as a direct consequence of the lateral membrane stresses. Conditions under which these protein assemblies will cause the lipid membrane to curve are explored and we predict that a critical cluster size is required for this to happen. We go on to demonstrate that under the stress conditions taking place in the cellular membrane as it undergoes large-scale membrane remodeling, the M2 protein will in principle be able to both contribute to curvature induction and sense curvature in order to line up in manifolds where local membrane line tension is high. M2 is found to exhibit linactant behavior in liquid-disordered/liquid-ordered phase-separated lipid mixtures and to be excluded from the liquid-ordered phase, in near-quantitative agreement with experimental observations. Our findings support a role for M2 in membrane remodeling during influenza viral budding both as an inducer and a sensor of membrane curvature, and they suggest a mechanism by which localization of M2 can occur as the virion assembles and releases from the host cell, independent of how the membrane curvature is produced

Digital Signal Processing Research Program

Contains table of contents for Section 2, an introduction, reports on sixteen research projects and a list of publications.Bose CorporationMIT-Woods Hole Oceanographic Institution Joint Graduate Program in Oceanographic EngineeringAdvanced Research Projects Agency/U.S. Navy - Office of Naval Research Grant N00014-93-1-0686Lockheed Sanders, Inc./U.S. Navy - Office of Naval Research Contract N00014-91-C-0125U.S. Air Force - Office of Scientific Research Grant AFOSR-91-0034AT&T Laboratories Doctoral Support ProgramAdvanced Research Projects Agency/U.S. Navy - Office of Naval Research Grant N00014-89-J-1489U.S. Navy - Office of Naval Research Grant N00014-93-1-0686National Science Foundation FellowshipMaryland Procurement Office Contract MDA904-93-C-4180U.S. Navy - Office of Naval Research Grant N00014-91-J-162

Digital Signal Processing Research Program

Contains table of contents for Section 2, an introduction, reports on twenty research projects and a list of publications.Lockheed Sanders, Inc. Contract BZ4962U.S. Army Research Laboratory Grant QK-8819U.S. Navy - Office of Naval Research Grant N00014-93-1-0686National Science Foundation Grant MIP 95-02885U.S. Navy - Office of Naval Research Grant N00014-95-1-0834U.S. Navy - Office of Naval Research Grant N00014-96-1-0930U.S. Navy - Office of Naval Research Grant N00014-95-1-0362National Defense Science and Engineering FellowshipU.S. Air Force - Office of Scientific Research Grant F49620-96-1-0072National Science Foundation Graduate Research Fellowship Grant MIP 95-02885Lockheed Sanders, Inc. Grant N00014-93-1-0686National Science Foundation Graduate FellowshipU.S. Army Research Laboratory/ARL Advanced Sensors Federated Lab Program Contract DAAL01-96-2-000

Digital Signal Processing Research Program

Contains table of contents for Section 2, an introduction, reports on twenty-two research projects and a list of publications.Sanders, a Lockheed-Martin Corporation Contract BZ4962U.S. Army Research Laboratory Contract DAAL01-96-2-0001U.S. Navy - Office of Naval Research Grant N00014-93-1-0686National Science Foundation Grant MIP 95-02885U.S. Navy - Office of Naval Research Grant N00014-96-1-0930National Defense Science and Engineering FellowshipU.S. Air Force - Office of Scientific Research Grant F49620-96-1-0072U.S. Navy - Office of Naval Research Grant N00014-95-1-0362National Science Foundation Graduate Research FellowshipAT&T Bell Laboratories Graduate Research FellowshipU.S. Army Research Laboratory Contract DAAL01-96-2-0002National Science Foundation Graduate FellowshipU.S. Army Research Laboratory/Advanced Sensors Federated Lab Program Contract DAAL01-96-2-000

Broadband modal coherence and beamforming at megameter ranges

Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2000.Includes bibliographical references (leaves 140-146).by Kathleen E. Wage.Ph.D

Adaptive estimation of acoustic normal modes

Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1994.Includes bibliographical references (p. 99-101).Kathleen E. Wage.M.S