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Supplementary Material for: The IL20 Genetic Polymorphism Is Associated with Altered Clinical Outcome in Septic Shock
Background: The IL10 family of genes includes crucial immune
regulators. We tested the hypothesis that single nucleotide
polymorphisms (SNPs) in IL10 , IL19 , IL20 , and IL24 of the
IL10 family gene cluster alter the clinical outcome of septic
shock. Methods: Patients with septic shock ( n = 1,193) were
genotyped for 13 tag SNPs of IL10 , IL19 , IL20 , and IL24 . IL20
gene expression was measured in genotyped lymphoblastoid
cells in vitro. Cardiac surgical ICU patients ( n = 981) were
genotyped for IL20 rs2981573 A/G. The primary outcome
variable was 28-day mortality. Results: Patients with the G
allele of IL20 rs2981573 had a significantly increased hazard
of death over the 28-day period compared to patients with
the A allele in the septic shock cohort (adjusted hazard ratio
1.27; 95% confidence interval 1.10–1.47; p = 8.0 × 10 –4 ). Patients
with the GG genotype had more organ dysfunction ( p < 0.05). The GG genotype was associated with increased
IL20 gene expression in stimulated lymphoblastoid cells in
vitro ( p < 0.05). The cardiac surgical ICU patients with the GG
genotype had an increased length of ICU stay ( p = 0.032).
Conclusions: The GG genotype of IL20 rs2981573 SNP was
associated with increased IL20 gene expression and increased
adverse outcomes in patients with septic shock and
following cardiac surgery. <br