20 research outputs found
Separating lentiviral vector injection and induction of gene expression in time, does not prevent an immune response to rtTA in rats
Organic anion transporting polypeptide 1a/1b-knockout mice provide insights into hepatic handling of bilirubin, bile acids, and drugs
Organic anion transporting polypeptide 1a/1b-knockout mice provide insights into hepatic handling of bilirubin, bile acids, and drugs
Basolateral and apical ABC transporters in liver and intestine
De stofwisseling speelt een belangrijke rol in de eliminatie van lichaamsvreemde stoffen zoals medicijnen. Daarnaast is het transport door eiwitten belangrijk, zoals bijvoorbeeld de ATP-bindende cassette-transporters. Dirk de Waart toont aan dat eliminatie van stoffen vaak afhankelijk is van meerdere van deze eiwitten. Hij beschrijft voor een scala aan geneesmiddelen (zowel bestaande medicijnen als medicijnen in ontwikkeling) hoe de farmacokinetiek (de snelheid van klaring maar ook de verdeling over verschillende organen) samenhangt met activiteit en affiniteit van deze transporteiwitten
Influence of biliary cirrhosis on the detoxification and elimination of a food derived carcinogen
Absorption, distribution, and biliary excretion of cafestol, a potent cholesterol-elevating compound in unfiltered coffees, in mice.
Cafestol is a diterpene present in unfiltered coffees. It is the most potent cholesterol-elevating compound present in the human diet. However, the precise mechanisms underlying this effect are still unclear. In contrast, cafestol is also known as a hepatoprotective compound, which is likely to be related to the induction of glutathione biosynthesis and conjugation. In the present study, we investigated whole-body distribution, biliary excretion, and portal bioavailability of cafestol in mice. First, dissection was used to study distribution. Five hours after an oral dose wit