<i>Cis</i> P-tau is induced in clinical and preclinical brain injury and contributes to post-injury sequelae

Induction of the cis form of phosphorylated tau (cis P-tau) has previously been shown to occur in animal models of traumatic brain injury (TBI), and blocking this form of tau using antibody was beneficial in a rodent model of severe TBI. Here the authors show that cis P-tau induction is a feature of several different forms of TBI in humans, and that administration of cis P-tau targeting antibody to rodents reduces or delays pathological features of TBI

Mind Your Head: Potential Short- and Long-Term Effects of Concussion in Sport

Concussions are becoming an important topic in sports research and has gained significant public attention in recent years. What sometimes used to be considered just a bump or a jolt to the head is now clearly considered a true brain injury. Even more concerning, injuries that were previously considered minor can have major impacts on the individual-both short-term and long-term. However, while we may recognize concussions in the acute setting on the playing field, there is limited knowledge about the long-term impact of both concussions and sub-concussive head impacts (e.g., the heading of a football). Despite these knowledge gaps, there appears to be sufficient evidence that current protocols, if properly used, are effective tools in the clinical identification of concussion or more severe brain injury and management of return to training and competition if properly used [1, 2].In this report, we summarize the most important information about concussions, including their occurrence, symptoms, pathophysiology, and short-term and long-term effects. Our aim is to underscore the importance of following current guidelines and getting expert advice when an athlete has sustained a head injury. Doing so will ensure the best possible outcome and avoid potentially devastating long-term sequelae.</p