Pengaruh Budaya Organisasi, Komunikasi Interpersonal, dan Perilaku Inovatif, terhadap Motivasi Kerja Guru Sekolah Dasar Negeri di Kabupaten Labuhan Batu

Abstract: The purpose of this research is to determine and analysis: (1) the effect of organizational culture on innovative behavior, (2) the effect of interpersonal communication on innovative behavior, (3) the effect of organizational culture on work motivation, (4) the effect of interpersonal communication on work motivation, and (5) the effect of innovative behavior on work motivation. The research subjects were the teachers of the State Elementary School of Labuhan Batu Regency with a total sample of 142 people taken by means of stratified proportional random sampling, the data were analyzed using path analysis after calculating the correlation of all research variables in the form of a matrix.. The analysis results of the effect exogenous variables on endogenous variables in each substructure obtained (1) organizational culture, interpersonal communication, and innovative behavior have a positive effect on teacher work motivation by 7.7%; 4.7% and 9.7% (2) innovative behavior is influenced by teacher work motivation by 5.3%. The results of the study illustrate that (1) there is a direct positive influence of organizational culture on innovative behavior by 5.24%, (2) there is a direct positive influence of interpersonal communication on innovative behavior of 3.09%, (3) there is a direct positive influence of organizational culture on work motivation, (4) there is an effect of interpersonal communication on work motivation, and (5) there is an influence of innovative behavior on work motivation.. Keyword: Organizational Culture, Interpersonal Communication, Innovative Behavior, and Work Motivation Abstrak: Tujuan penelitian ini adalah untuk mengetahui dan menganalisis: (1) pengaruh budaya organisasi terhadap perilaku inovatif, (2) pengaruh komunikasi interpersonal terhadap perilaku inovatif, (3) pengaruh budaya organisasi terhadap motivasi kerja, (4) pengaruh komunikasi interpersonal terhadap motivasi kerja, dan (5) pengaruh perilaku inovatif terhadap motivasi kerja. Subjek penelitian adalah para guru Sekolah Dasar Negeri Kabupaten Labuhan Batu dengan jumlah sampel sebanyak 283 orang yang diambil dengan cara stratified proportional random sampling, data dianalisis dengan menggunakan analisis jalur setelah dihitung korelasi seluruh variabel penelitian dalam bentuk matriks. Hasil analisis pengaruh variabel eksogen terhadap variabel endogen pada masing-masing substruktur diperoleh (1) budaya organisasi, komunikasi interpersonal, dan perilaku inovatif berpengaruh positif terhadap motivasi kerja guru sebesar 7,7%; 4,7% dan 9,7%  (2) perilaku inovatif dipengaruhi oleh motivasi kerja guru sebesar 5,3%. Hasil penelitian memberikan gambaran bahwa (1) ada pengaruh langsung positif budaya organisasi terhadap perilaku inovatif sebesar 5,24%, (2) ada pengaruh langsung positif komunikasi interpersonal terhadap perilaku inovatif 3,09%, (3) ada pengaruh langsung positif budaya organisasi terhadap motivasi kerja, (4) ada pengaruh komunikasi interpersonal terhadap motivasi kerja, dan (5) ada pengaruh perilaku inovatif terhadap motivasi kerja. Kata Kunci: Budaya Organisasi, Komunikasi Interpersonal, Perilaku Inovatif, dan Motivasi Kerj

Retrospective analysis of the treatment of BRCA1 and BRCA2 mutation carriers – the experience of a single-center tertiary institution

Introduction.Breast cancer gene 1 and 2 (BRCA1/2) mutation carriers are at a higher risk of developing breast cancer. There are several established risk-reducing therapies. Our study aimed to characterize the BRCA1/2 mutation carriers, and to evaluate the implemented treatment methods. Material and methods.A retrospective analysis of clinical records of 96 female patients hospitalized from October 2019 to December 2022 in the Breast Cancer Unit in Lodz, Poland. Results.Out of 85 BRCA1 and 11 BRCA2 mutation carriers, 96.88% received nipple-sparing or skin-sparing, unilateral or bilateral risk-reducing mastectomies. Out of all the patients, 36 developed 38 breast cancers. One patient was diagnosed with breast cancer 2 years after a bilateral risk-reducing mastectomy. The most common breast cancer subtype was triple-negative breast cancer (73.68%). The patients could receive surgery, chemotherapy, endocrine therapy and radio­therapy. 18 patients had neoadjuvant chemotherapy, in 6 of these patients a complete pathological response (ypT0N0) was achieved. Conclusions.Oncoplastic bilateral risk-reducing mastectomies are effective and safe procedures

INVESTMENT ANALYSIS OF VIETNAM

Vietnam has changed in the last thirty years from an agrarian country to a service and manufacture country leader in the world in growth and economic activity. The country has a communist system legally but, in the practice, the country has a liberal policy in the economy signing the Trans-Pacific Free Trade Agreement but maintaining the political control under the rule of one party. The country offers opportunities and risks for individual and corporation with the intention to invest

The molecular portrait of triple-negative breast cancer: the LAG3 gene single nucleotide polymorphism rs2365094 has no impact on the clinical picture

Introduction. Triple-negative breast cancer (TNBC) is characterized by a lack of oestrogen, progesterone and human epidermal growth factor receptors. It is the one of most heterogeneous and highly-aggressive breast cancers, resulting in fast progression. In humans, the lymphocyte activation gene 3 (LAG3) is located on chromosome 12p13 and encodes an immune-regulatory molecule. The aim of the study was to perform a molecular analysis of LAG3 gene polymorphisms.  Material and method. The presence of single-nucleotide polymorphisms (SNPs) at rs2365094 was determined in 30 TNBC patients and 30 healthy controls using a polymerase chain reaction (PCR) and commercially-available TaqMan SNP Genotyping Assays. SNP status was then compared with the clinical outcome.  Results. The allelic alterations in LAG3 gene SNP in rs2365094 appear to have no influence on the clinicopathological picture among TNBC patients. The carriage rate for a single allele did not differ significantly between patients and controls.  Conclusions. No significant relationship was observed between the rs2365094 SNP status and clinicopathological determinants.

The molecular portrait of triple-negative breast cancer: the LAG3 gene single nucleotide polymorphism rs2365094 has no impact on the clinical picture

Introduction. Triple-negative breast cancer (TNBC) is characterized by a lack of estrogen, progesterone and human epidermal growth factor receptors. It is the one of most heterogeneous and highly-aggressive breast cancers, resulting in fast progression. In humans, the lymphocyte activation gene 3 (LAG3) is located on chromosome 12p13 and encodes an immune-regulatory molecule. The aim of the study was to perform a molecular analysis of LAG3 gene polymorphisms. Material and method. The presence of single-nucleotide polymorphisms (SNPs) at rs2365094 was determined in 30 TNBC patients and 30 healthy controls using polymerase chain reaction (PCR) and commercially-available TaqMan SNP Genotyping Assays. SNP status was the compared with clinical outcome. Results. The allelic alterations in LAG3 gene SNP in rs2365094 appear to have no influence on the clinicopathological picture among TNBC patients. The carriage rate for a single allele did not differ significantly between patients and controls. Conclusions. No significant relationship was observed between rs2365094 SNP status and clinicopathological determinants

Liquid biopsy in targeting gene polymorphism related to the response within immunocheckpoint inhibitors therapeutic regimen

Immunotherapy belongs to the group of targeted therapies; it is based on natural immune mechanisms which axis can be promoted or blocked at appropriate points. Breast cancer is the world’s most common cancer among women and in March 2019 the FDA approved the first immunopharmaceutical Atezolizumab, for the treatment of breast cancer. So far, the only registered marker for classification for checkpoint inhibitor therapy has been the presence of PD-L1 receptor expression in tumour cells. A comprehensive search of the literature to elucidate the correlation between PD-1/PD-L1 single nucleotide polymorphism (SNP) and cancer, especially breast cancer or other diseases susceptibility and PD-1/ PD-L1 expression. Seven susceptibility loci was considered: rs41386349, rs7421861, rs36084323, rs11568821, rs2227981, rs10204525, rs2227982. Three of them may be taken into account as potentially helpful in breast cancer patient treatment tailoring: rs36084323, rs2227981, rs2227982

A Retrospective Study Assessing the Outcomes of Immediate Prepectoral and Subpectoral Implant and Mesh-Based Breast Reconstruction

(1) Introduction: In response to patient concerns about breast cancer recurrence, increased use of breast magnetic resonance imaging and genetic testing, and advancements in breast reconstruction techniques, mastectomy rates have been observed to rise over the last decade. The aim of the study is to compare the outcomes of prepectoral and subpectoral implants and long-term, dual-stage resorbable mesh-based breast reconstructions in mutation carriers (prophylactic surgery) and breast cancer patients. (2) Patients and methods: This retrospective, two-center study included 170 consecutive patients after 232 procedures: Prepectoral surgery was performed in 156 cases and subpectoral was performed in 76. (3) Results: Preoperative chemotherapy was associated with more frequent minor late complications (p < 0.001), but not major ones (p = 0.101), while postoperative chemotherapy was related to more frequent serious (p = 0.005) postoperative complications. Postoperative radiotherapy was associated with a higher rate of minor complications (31.03%) than no-radiotherapy (12.21%; p < 0.001). Multivariate logistic regression found complications to be significantly associated with an expander (OR = 4.43), skin-reducing mastectomy (OR = 9.97), therapeutic mastectomy vs. risk-reducing mastectomy (OR = 4.08), and postoperative chemotherapy (OR = 12.89). Patients in whom prepectoral surgeries were performed demonstrated significantly shorter median hospitalization time (p < 0.001) and lower minor complication rates (5.77% vs. 26.32% p < 0.001), but similar major late complication rates (p = 0.915). (4) Conclusions: Implant-based breast reconstruction with the use of long-term, dual-stage resorbable, synthetic mesh is a safe and effective method of breast restoration, associated with low morbidity and good cosmesis. Nevertheless, prospective, multicenter, and long-term outcome data studies are needed to further evaluate the benefits of such treatments

Retrospective analysis of the treatment of BRCA1 and BRCA2 mutation carriers – the experience of a single-center tertiary institution

Introduction.Breast cancer gene 1 and 2 (BRCA1/2) mutation carriers are at a higher risk of developing breast cancer. There are several established risk-reducing therapies. Our study aimed to characterize the BRCA1/2 mutation carriers, and to evaluate the implemented treatment methods. Material and methods.A retrospective analysis of clinical records of 96 female patients hospitalized from October 2019 to December 2022 in the Breast Cancer Unit in Lodz, Poland. Results.Out of 85 BRCA1 and 11 BRCA2 mutation carriers, 96.88% received nipple-sparing or skin-sparing, unilateral or bilateral risk-reducing mastectomies. Out of all the patients, 36 developed 38 breast cancers. One patient was diagnosed with breast cancer 2 years after a bilateral risk-reducing mastectomy. The most common breast cancer subtype was triple-negative breast cancer (73.68%). The patients could receive surgery, chemotherapy, endocrine therapy and radio­therapy. 18 patients had neoadjuvant chemotherapy, in 6 of these patients a complete pathological response (ypT0N0) was achieved. Conclusions.Oncoplastic bilateral risk-reducing mastectomies are effective and safe procedures