Calculation of the relative metastabilities of proteins in subcellular compartments of Saccharomyces cerevisiae

[abridged] Background: The distribution of chemical species in an open system at metastable equilibrium can be expressed as a function of environmental variables which can include temperature, oxidation-reduction potential and others. Calculations of metastable equilibrium for various model systems were used to characterize chemical transformations among proteins and groups of proteins found in different compartments of yeast cells. Results: With increasing oxygen fugacity, the relative metastability fields of model proteins for major subcellular compartments go as mitochondrion, endoplasmic reticulum, cytoplasm, nucleus. In a metastable equilibrium setting at relatively high oxygen fugacity, proteins making up actin are predominant, but those constituting the microtubule occur with a low chemical activity. A reaction sequence involving the microtubule and spindle pole proteins was predicted by combining the known intercompartmental interactions with a hypothetical program of oxygen fugacity changes in the local environment. In further calculations, the most-abundant proteins within compartments generally occur in relative abundances that only weakly correspond to a metastable equilibrium distribution. However, physiological populations of proteins that form complexes often show an overall positive or negative correlation with the relative abundances of proteins in metastable assemblages. Conclusions: This study explored the outlines of a thermodynamic description of chemical transformations among interacting proteins in yeast cells. The results suggest that these methods can be used to measure the degree of departure of a natural biochemical process or population from a local minimum in Gibbs energy.Comment: 32 pages, 7 figures; supporting information is available at http://www.chnosz.net/yeas

Change & Maintaining Change in School Cafeterias: Economic and Behavioral-Economic Approaches to Increasing Fruit and Vegetable Consumption

Developing a daily habit of consuming fruits and vegetables (FV) in children is an important public-health goal. Eating habits acquired in childhood are predictive of adolescent and adult dietary patterns. Thus, healthy eating patterns developed early in life can protect the individual against a number of costly health deficits and may reduce the prevalence of obesity. At present, children in the United States (US) under-consume FV despite having access to them through the National School Lunch Program. Because access is an obstacle to developing healthy eating habits, particularly in low-income households, targeting children’s FV consumption in schools has the advantage of near-universal FV availability among more than 30 million US children. This chapter reviews economic and behavioral-economic approaches to increasing FV consumption in schools. Inclusion criteria include objective measurement of FV consumption (e.g., plate waste measures) and minimal demand characteristics. Simple but effective interventions include (a) increasing the variety of vegetables served, (b) serving sliced instead of whole fruits, (c) scheduling lunch after recess, and (d) giving children at least 25 minutes to eat. Improving the taste of FV and short-term incentivizing consumption of gradually increasing amounts can produce large increases in consumption of these foods. Low-cost game-based incentive program may increase the practicality of the latter strategy

Multisensory vocal communication in primates and the evolution of rhythmic speech

The integration of the visual and auditory modalities during human speech perception is the default mode of speech processing. That is, visual speech perception is not a capacity that is “piggybacked” on to auditory-only speech perception. Visual information from the mouth and other parts of the face is used by all perceivers to enhance auditory speech. This integration is ubiquitous and automatic and is similar across all individuals across all cultures. The two modalities seem to be integrated even at the earliest stages of human cognitive development. If multisensory speech is the default mode of perception, then this should be reflected in the evolution of vocal communication. The purpose of this review is to describe the data that reveal that human speech is not uniquely multisensory. In fact, the default mode of communication is multisensory in nonhuman primates as well but perhaps emerging with a different developmental trajectory. Speech production, however, exhibits a unique bimodal rhythmic structure in that both the acoustic output and the movements of the mouth are rhythmic and tightly correlated. This structure is absent in most monkey vocalizations. One hypothesis is that the bimodal speech rhythm may have evolved through the rhythmic facial expressions of ancestral primates, as indicated by mounting comparative evidence focusing on the lip-smacking gesture

Attachment states of mind and couple relationships in couples seeking to adopt

We present the results of a study carried out in Italy with 39 Italian couples seeking to adopt, aged between 35 and 45 years, and 39 matched non-adoptive couples which compared their attachment states of mind with respect to caregivers and partners and quality of couple relationship. Both partners of the couples completed individually measures of attachment to caregiver (Adult Attachment Interview; AAI), attachment to partner (Current Relationship Interview; CRI and Experiences in Close Relationships Scale-Revised; ECR-R) and marital quality (Dyadic Adjustment Scale; DAS). The results showed that couples seeking to adopt did not differ from the control group with respect to attachment to caregivers (AAI). However potential adoptive fathers were more likely to show secure attachment classifications with respect to partner (CRI) than non-adoptive fathers. Finally, couples seeking to adopt expressed higher levels of positive feelings and thoughts within the couple relationship (ECR-R) and better perceived quality of marital relationship (DAS) than the control group. Overall, these findings suggested that couples seeking to adopt placed a high value on attachment relationships, which is considered a relevant factor for positive outcome of adoption

Can biological motion research provide insight on how to reduce friendly fire incidents?

The ability to accurately detect, perceive, and recognize biological motion can be associated with a fundamental drive for survival, and it is a significant interest for perception researchers. This field examines various perceptual features of motion and has been assessed and applied in several real-world contexts (e.g., biometric, sport). Unexplored applications still exist however, including the military issue of friendly fire. There are many causes and processes leading to friendly fire and specific challenges that are associated with visual information extraction during engagement, such as brief glimpses, low acuity, camouflage, and uniform deception. Furthermore, visual information must often be processed under highly stressful (potentially threatening), time-constrained conditions that present a significant problem for soldiers. Biological motion research and anecdotal evidence from experienced combatants suggests that intentions, emotions, identities of human motion can be identified and discriminated, even when visual display is degraded or limited. Furthermore, research suggests that perceptual discriminatory capability of movement under visually constrained conditions is trainable. Therefore, given the limited military research linked to biological motion and friendly fire, an opportunity for cross-disciplinary investigations exists. The focus of this paper is twofold: first, to provide evidence for the possible link between biological motion factors and friendly fire, and second, to propose conceptual and methodological considerations and recommendations for perceptual-cognitive training within current military programs

Family Structure and the Nature of Couple Relationships: Relationship Distress, Separation, Divorce, and Repartnering

The goal of this chapter is to review the current state of theoretical and empirical knowledge on the quality of the couple relationship and the family structure as determinants of parenting behavior. Ample evidence has accumulated over the past few decades that the functioning of the interparental relationship is pivotal for positive and supportive parenting. Supporting the spillover theory, relationship distress among parenting couples may increase child maladjustment, both directly and indirectly, by disrupted child-rearing and less optimal coparenting. In separated or divorced families, coparenting is a key concept to explain why some couples succeed in compartmentalizing their parenting from their spousal role. As such, cooperative coparenting has been firmly established as a central protective factor buffering the impact of parental separation on children. Based on the reviewed data among stepfamilies, it can be tentatively concluded that a cohabiting stepparent may become a significant new caregiver for the child, but only on condition of good stepparent–child relationship quality, which has emerged as crucially important for children’s adjustment in the new family environment. This chapter posits that the interparental relationship can be regarded as the key relation which is responsible for family functioning across different family types (nuclear, divorced, and stepfamilies). As a practical implication, it might, therefore, be wise to strengthen this core relationship as a potential leverage point to positively affect parents’ individual parenting and their joint coparental alliance