31 research outputs found
The Galaxy Structure-Redshift Relationship
There exists a gradual, but persistent, evolutionary effect in the galaxy
population such that galaxy structure and morphology change with redshift. This
galaxy structure-redshift relationship is such that an increasingly large
fraction of all bright and massive galaxies at redshifts 2 < z < 3 are
morphologically peculiar at wavelengths from rest-frame ultraviolet to
rest-frame optical. There are however examples of morphologically selected
spirals and ellipticals at all redshifts up to z ~ 3. At lower redshift, the
bright galaxy population smoothly transforms into normal ellipticals and
spirals. The rate of this transformation strongly depends on redshift, with the
swiftest evolution occurring between 1 < z < 2. This review characterizes the
galaxy structure-redshift relationship, discusses its various physical causes,
and how these are revealing the mechanisms responsible for galaxy formation.Comment: 20 pages, 8 figures. Invited Review to appear in "Penetrating Bars
Through Masks of Cosmic Dust: The Hubble Tuning Fork Strikes A New Note", ed.
D. Block et a
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BENEFIT RISK JUDGMENTS FOR PATIENTS RECEIVING RETINOIDS ON A SHORT-TERM AND LONG-TERM BASIS - PANEL DISCUSSION
Vitamin A derivatives in the prevention and treatment of human cancer.
Vitamin A is essential for normal cellular growth and differentiation. A vast amount of laboratory data have clearly demonstrated the potent antiproliferative and differentiation-inducing effects of vitamin A and the synthetic analogues (retinoids). Recent in-vitro work has led to the exciting proposal that protein kinase-C may be centrally involved in many of retinoids' anticancer actions including the effects on ornithine decarboxylase induction, intracellular polyamine levels, and epidermal growth factor receptor number. Several intervention trials have clearly indicated that natural vitamin A at clinically tolerable doses has only limited activity against human neoplastic processes. Therefore, clinical work has focused on the synthetic derivatives with higher therapeutic indexes. In human cancer prevention, retinoids have been most effective for skin diseases, including actinic keratosis, keratoacanthoma, epidermodysplasia verruciformis, dysplastic nevus syndrome, and basal cell carcinoma. Several noncutaneous premaligancies, however, are currently receiving more attention in retinoid trials. Definite retinoid activity has been documented in oral leukoplakia, laryngeal papillomatosis, superficial bladder carcinoma, cervical dysplasia, bronchial metaplasia, and preleukemia. Significant therapeutic advances are also occurring with this class of drugs in some drug-resistant malignancies and several others that have become refractory, including advanced basal cell cancer, mycosis fungoides, melanoma, acute promyelocytic leukemia, and squamous cell carcinoma of the skin and of the head and neck. This report comprehensively presents the clinical data using retinoids as anticancer agents in human premalignant disorders and outlines the ongoing and planned studies with retinoids in combination and adjuvant therapy