10 research outputs found

    Literature Watch

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    Finance information systems usage in universities in a developing country : Implementing factors and their influence on use

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    Finance information systems (FISs) store and provide timely, accurate and consistent financial data for management and decision-making. Many organizations especially in developing world however fail to attain desired success during implementation and usage of the FISs despite the fact that many success factors for implementation have been suggested. This study thus investigated the usage of FISs with the aim of finding out how factors presumed to influence implementation impact usage. The presumed factors included; top management support, effective communication, evaluation of staff performance, technical support, project management, change management program, effectiveness of IT unit and flexibility of consultants. The study focused on universities in Uganda which is a developing country. Of the nine factors that were investigated only top management support, technical training and flexibility of consultants exhibited a positive impact with only top management support being significant. The rest of the factors exhibited negative impact and only effective IT unit being significant

    Influences of Web interactivity and social identity and bonds on the quality of online discussion in a virtual community

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    [[abstract]]People participate in virtual communities (VCs) for knowledge sharing or social interaction. However, most studies of VCs have focused on elucidating knowledge sharing rather than predicting virtual social interactions. This study considers “quality of online discussion” an appropriate metric for assessing group-level outcomes of virtual social interactions, and thus for predicting member willingness to sustain an ongoing relationship with a virtual community (VC). This study develops a research model, grounded in Web interactivity, social identity and social bond theories, for predicting the quality of online discussion in terms of cognitive and social influences. Empirical results from an online survey of a VC verify distinct direct and indirect social influences (perceived internalization bonds and perceived identification bonds) and cognitive influences (perceived communication and perceived control). Implications for academics and practitioners are also discussed

    Contribution of Neutrophils to Acute Lung Injury

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    Treatment of acute lung injury (ALI) and its most severe form, acute respiratory distress syndrome (ARDS), remain unsolved problems of intensive care medicine. ALI/ARDS are characterized by lung edema due to increased permeability of the alveolar-capillary barrier and subsequent impairment of arterial oxygenation. Lung edema, endothelial and epithelial injury are accompanied by an influx of neutrophils into the interstitium and broncheoalveolar space. Hence, activation and recruitment of neutrophils are regarded to play a key role in progression of ALI/ARDS. Neutrophils are the first cells to be recruited to the site of inflammation and have a potent antimicrobial armour that includes oxidants, proteinases and cationic peptides. Under pathological circumstances, however, unregulated release of these microbicidal compounds into the extracellular space paradoxically can damage host tissues. This review focuses on the mechanisms of neutrophil recruitment into the lung and on the contribution of neutrophils to tissue damage in ALI

    The application of discovery toxicology and pathology towards the design of safer pharmaceutical lead candidates

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