927 research outputs found
Complete quantum teleportation using nuclear magnetic resonance
Quantum mechanics provides spectacular new information processing abilities
(Bennett 1995, Preskill 1998). One of the most unexpected is a procedure called
quantum teleportation (Bennett et al 1993) that allows the quantum state of a
system to be transported from one location to another, without moving through
the intervening space. Partial implementations of teleportation (Bouwmeester et
al 1997, Boschi et al 1998) over macroscopic distances have been achieved using
optical systems, but omit the final stage of the teleportation procedure. Here
we report an experimental implementation of the full quantum teleportation
operation over inter-atomic distances using liquid state nuclear magnetic
resonance (NMR). The inclusion of the final stage enables for the first time a
teleportation implementation which may be used as a subroutine in larger
quantum computations, or for quantum communication. Our experiment also
demonstrates the use of quantum process tomography, a procedure to completely
characterize the dynamics of a quantum system. Finally, we demonstrate a
controlled exploitation of decoherence as a tool to assist in the performance
of an experiment.Comment: 15 pages, 2 figures. Minor differences between this and the published
versio
Big bang simulation in superfluid 3He-B -- Vortex nucleation in neutron-irradiated superflow
We report the observation of vortex formation upon the absorption of a
thermal neutron in a rotating container of superfluid He-B. The nuclear
reaction n + He = p + H + 0.76MeV heats a cigar shaped region of the
superfluid into the normal phase. The subsequent cooling of this region back
through the superfluid transition results in the nucleation of quantized
vortices. Depending on the superflow velocity, sufficiently large vortex rings
grow under the influence of the Magnus force and escape into the container
volume where they are detected individually with nuclear magnetic resonance.
The larger the superflow velocity the smaller the rings which can expand. Thus
it is possible to obtain information about the morphology of the initial defect
network. We suggest that the nucleation of vortices during the rapid cool-down
into the superfluid phase is similar to the formation of defects during
cosmological phase transitions in the early universe.Comment: 4 pages, LaTeX file, 4 figures are available at
ftp://boojum.hut.fi/pub/publications/lowtemp/LTL-95009.p
Parameters of Pseudo-Random Quantum Circuits
Pseudorandom circuits generate quantum states and unitary operators which are
approximately distributed according to the unitarily invariant Haar measure. We
explore how several design parameters affect the efficiency of pseudo-random
circuits, with the goal of identifying relevant trade-offs and optimizing
convergence. The parameters we explore include the choice of single- and
two-qubit gates, the topology of the underlying physical qubit architecture,
the probabilistic application of two-qubit gates, as well as circuit size,
initialization, and the effect of control constraints. Building on the
equivalence between pseudo-random circuits and approximate -designs, a
Markov matrix approach is employed to analyze asymptotic convergence properties
of pseudo-random second-order moments to a 2-design. Quantitative results on
the convergence rate as a function of the circuit size are presented for qubit
topologies with a sufficient degree of symmetry. Our results may be
theoretically and practically useful to optimize the efficiency of random state
and operator generation.Comment: 17 pages, 14 figures, 2 Appendice
Spontaneous symmetry breaking in a quenched ferromagnetic spinor Bose condensate
A central goal in condensed matter and modern atomic physics is the
exploration of many-body quantum phases and the universal characteristics of
quantum phase transitions in so far as they differ from those established for
thermal phase transitions. Compared with condensed-matter systems, atomic gases
are more precisely constructed and also provide the unique opportunity to
explore quantum dynamics far from equilibrium. Here we identify a second-order
quantum phase transition in a gaseous spinor Bose-Einstein condensate, a
quantum fluid in which superfluidity and magnetism, both associated with
symmetry breaking, are simultaneously realized. Rb spinor condensates
were rapidly quenched across this transition to a ferromagnetic state and
probed using in-situ magnetization imaging to observe spontaneous symmetry
breaking through the formation of spin textures, ferromagnetic domains and
domain walls. The observation of topological defects produced by this symmetry
breaking, identified as polar-core spin-vortices containing non-zero spin
current but no net mass current, represents the first phase-sensitive in-situ
detection of vortices in a gaseous superfluid.Comment: 6 pages, 4 figure
Counting defects with the two-point correlator
We study how topological defects manifest themselves in the equal-time
two-point field correlator. We consider a scalar field with Z_2 symmetry in 1,
2 and 3 spatial dimensions, allowing for kinks, domain lines and domain walls,
respectively. Using numerical lattice simulations, we find that in any number
of dimensions, the correlator in momentum space is to a very good approximation
the product of two factors, one describing the spatial distribution of the
defects and the other describing the defect shape. When the defects are
produced by the Kibble mechanism, the former has a universal form as a function
of k/n, which we determine numerically. This signature makes it possible to
determine the kink density from the field correlator without having to resort
to the Gaussian approximation. This is essential when studying field dynamics
with methods relying only on correlators (Schwinger-Dyson, 2PI).Comment: 11 pages, 7 figures
The sphere-in-contact model of carbon materials
A sphere-in-contact model is presented that is used to build physical models of carbon materials such as graphite, graphene, carbon nanotubes and fullerene. Unlike other molecular models, these models have correct scale and proportions because the carbon atoms are represented by their atomic radius, in contrast to the more commonly used space-fill models, where carbon atoms are represented by their van der Waals radii. Based on a survey taken among 65 undergraduate chemistry students and 28 PhD/postdoctoral students with a background in molecular modeling, we found misconceptions arising from incorrect visualization of the size and location of the electron density located in carbon materials. Based on analysis of the survey and on a conceptual basis we show that the sphere-in-contact model provides an improved molecular representation of the electron density of carbon materials compared to other molecular models commonly used in science textbooks (i.e., wire-frame, ball-and-stick, space-fill). We therefore suggest that its use in chemistry textbooks along with the ball-and-stick model would significantly enhance the visualization of molecular structures according to their electron density
Cancer risk in hospitalised psoriasis patients: a follow-up study in Sweden
We examined overall and specific cancer risks among Swedish subjects who had been hospitalised one or more times for psoriasis. A database was created by identifying such patients from the Swedish Hospital Discharge Register and linking them with the Cancer Registry. Follow-up of patients was carried out from the last hospitalisation through 2004. A total of 15 858 patients were hospitalised for psoriasis during 1965–2004, of whom 1408 developed cancer, giving an overall standardised incidence ratios (SIRs) of 1.33. A significant excess was noted for squamous cell skin cancer, and for cancers of the upper aerodigestive tract, oesophagus, stomach, liver, pancreas, lung, kidney and bladder as well as non-Hodgkin lymphoma. Many of these may reflect the effects of alcohol drinking and tobacco smoking. Patients with multiple hospitalisations showed high risk, particularly for oesophageal (SIR 6.97) and skin (SIR 4.76) cancers
SLC2A10 genetic polymorphism predicts development of peripheral arterial disease in patients with type 2 diabetes. SLC2A10 and PAD in type 2 diabetes
<p>Abstract</p> <p>Background</p> <p>Recent data indicate that loss-of-function mutation in the gene encoding the facilitative glucose transporter GLUT10 (<it>SLC2A10</it>) causes arterial tortuosity syndrome via upregulation of the TGF-β pathway in the arterial wall, a mechanism possibly causing vascular changes in diabetes.</p> <p>Methods</p> <p>We genotyped 10 single nucleotide polymorphisms and one microsatellite spanning 34 kb across the <it>SLC2A10 </it>gene in a prospective cohort of 372 diabetic patients. Their association with the development of peripheral arterial disease (PAD) in type 2 diabetic patients was analyzed.</p> <p>Results</p> <p>At baseline, several common SNPs of <it>SLC2A10 </it>gene were associated with PAD in type 2 diabetic patients. A common haplotype was associated with higher risk of PAD in type 2 diabetic patients (haplotype frequency: 6.3%, <it>P </it>= 0.03; odds ratio [OR]: 14.5; 95% confidence interval [CI]: 1.3- 160.7) at baseline. Over an average follow-up period of 5.7 years, carriers with the risk-conferring haplotype were more likely to develop PAD (<it>P </it>= 0.007; hazard ratio: 6.78; 95% CI: 1.66- 27.6) than were non-carriers. These associations remained significant after adjustment for other risk factors of PAD.</p> <p>Conclusion</p> <p>Our data demonstrate that genetic polymorphism of the <it>SLC2A10 </it>gene is an independent risk factor for PAD in type 2 diabetes.</p
Measurement of GSTP1 promoter methylation in body fluids may complement PSA screening: a meta-analysis
Background: Prostate-specific antigen (PSA) screening has low specificity. Assessment of methylation status in body fluids may complement PSA screening if the test has high specificity. Method: The purpose of this study was to conduct a meta-analysis of the sensitivity and specificity for prostate cancer detection of glutathione-s-transferase–π (GSTP1) methylation in body fluids (plasma, serum, whole blood, urine, ejaculate, and prostatic secretions). We conducted a comprehensive literature search on Medline (Pubmed). We included studies if they met all four of the following criteria: (1) measurement of DNA methylation in body fluids; (2) a case-control or case-only design; (3) publication in an English journal; and (4) adult subjects. Reviewers conducted data extraction independently using a standardised protocol. Twenty-two studies were finally included in this paper. Primer sequences and methylation method in each study were summarised and evaluated using meta-analyses. This paper represents a unique cross-disciplinary approach to molecular epidemiology. Results: The pooled specificity of GSTP1 promoter methylation measured in plasma, serum, and urine samples from negative-biopsy controls was 0.89 (95% CI, 0.80–0.95). Stratified analyses consistently showed a high specificity across different sample types and methylation methods (include both primer sequences and location). The pooled sensitivity was 0.52 (95% CI, 0.40–0.64). Conclusions: The pooled specificity of GSTP1 promoter methylation measures in plasma, serum, and urine was excellent and much higher than the specificity of PSA. The sensitivity of GSTP1 was modest, no higher than that of PSA. These results suggest that measurement of GSTP1 promoter methylation in plasma, serum, or urine samples may complement PSA screening for prostate cancer diagnosis
A Cell-Based Model for Quorum Sensing in Heterogeneous Bacterial Colonies
Although bacteria are unicellular organisms, they have the ability to act in concert by synthesizing and detecting small diffusing autoinducer molecules. The phenomenon, known as quorum sensing, has mainly been proposed to serve as a means for cell-density measurement. Here, we use a cell-based model of growing bacterial microcolonies to investigate a quorum-sensing mechanism at a single cell level. We show that the model indeed predicts a density-dependent behavior, highly dependent on local cell-clustering and the geometry of the space where the colony is evolving. We analyze the molecular network with two positive feedback loops to find the multistability regions and show how the quorum-sensing mechanism depends on different model parameters. Specifically, we show that the switching capability of the network leads to more constraints on parameters in a natural environment where the bacteria themselves produce autoinducer than compared to situations where autoinducer is introduced externally. The cell-based model also allows us to investigate mixed populations, where non-producing cheater cells are shown to have a fitness advantage, but still cannot completely outcompete producer cells. Simulations, therefore, are able to predict the relative fitness of cheater cells from experiments and can also display and account for the paradoxical phenomenon seen in experiments; even though the cheater cells have a fitness advantage in each of the investigated groups, the overall effect is an increase in the fraction of producer cells. The cell-based type of model presented here together with high-resolution experiments will play an integral role in a more explicit and precise comparison of models and experiments, addressing quorum sensing at a cellular resolution
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