Parental absence in early childhood and onset of smoking and alcohol consumption before adolescence

Background: Parental absence, due to death or separation from a parent, has been associated with smoking and alcohol consumption in adolescence and adulthood. The aim of this study was to investigate whether parental absence in early childhood was associated with smoking and alcohol uptake before adolescence. / Methods: Data on 10,940 children from the UK’s Millennium Cohort Study were used. Logistic regression was used to test associations between parental absence (0-7 years) and reports of smoking and alcohol consumption at age 11. / Results: Children who experienced parental absence were more likely to have smoked (OR=2.58, 95% CI: 1.88, 3.56) and consumed alcohol (OR=1.46, 95% CI: 1.25, 1.72). No differences were found by child sex or age, or parent absent. Children who experienced parental death were less likely to have drunk alcohol but those who had were more likely to have consumed enough to feel drunk. / Conclusions: Parental absence was associated with early uptake of risky health behaviours in a large, nationally representative UK cohort. Children who experience parental absence should be supported in early life in order to prevent smoking and alcohol initiation

Inhibition of large conductance calcium-dependent potassium channel by Rho-kinase contributes to agonist-induced vasoconstriction

We tested the hypothesis that Rho-kinase inhibits the large-conductance, calcium and voltage dependent potassium (BKCa) channels thereby promoting vasoconstriction. Our results show that the Rho-kinase inhibitor, Y-27632, induced concentration-dependent relaxation in rat mesenteric artery. The selective BKCa channel inhibitors, iberiotoxin (0.1 mM) and tetraethylammonium (10 mM) increased the EC50 of Y-27632 more than 2-fold and decreased Y-27632-induced maximum relaxation (P<0.05). In the inside-out patch clamp configuration, constitutively active Rho-kinase (1mg/ml) attenuated BKCa channel activity induced by protein kinase G (PKG) (P<0.05). Y-27632 (10 mM) reversed the inhibitory effect of active Rhokinase (P<0.01). Furthermore, in the presence of Y-27632, addition of active Rho-kinase had no effect on PKG-stimulated BKCa channel activity. Taken together, our data suggest that Rho-kinase negatively regulates BKCa channels, thus providing a novel mechanism though which Rho-kinase increases smooth muscle contraction.Keywords: Rho, smooth muscle, hyperpolarization, vascular reactivity, mesenteric artery, patch clam

Informal caregiving and markers of adiposity in the UK Household Longitudinal Study

OBJECTIVES:The aim was to investigate associations between caregiving and adiposity using a representative UK longitudinal study. We also investigated whether associations differed by age, gender and caregiving characteristics. METHODS:Data on 9,421 participants aged 16+ from three waves (2009-2012) of the UK Household Longitudinal Study were used. Body mass index, waist circumference and percentage body fat were assessed. Caregiving and caregiving characteristics (hours per week, number of people cared for, co-resident caregiving and combining working and caregiving) was available from the prior wave. Gender-stratified associations between caregiving/caregiving characteristics with adiposity were tested. Covariates included caregiver's health, socioeconomic position, parenthood and partnerships. RESULTS:Caregiving was associated with higher adiposity for women but not men. Younger women caregivers had particularly higher levels of adiposity. Men combining part-time paid work with caregiving had higher levels of adiposity than men working full-time and not caregiving. Women aged 16-44 or 65+ had particularly high levels of adiposity when combining full-time work and caregiving, compared to full-time work alone. CONCLUSION:The health of caregivers should be a public health priority, particularly for younger women and those combining paid work with caregiving responsibilities

Informal caregiving patterns and trajectories of psychological distress in the UK Household Longitudinal Study

BACKGROUND: Approximately seven million people in the UK are engaged in informal caregiving. Informal caregivers are at risk of poorer mental and physical health. However, less is known about how the relationship between the informal caregiving and psychological distress changes over time. The aim of this study was to investigate longitudinal associations between the informal caregiving and psychological distress amongst UK men and women aged 16+. METHODS: Data were analysed from the UK Household Longitudinal Study (UKHLS, n = 9368), a nationally representative study of UK households. Longitudinal linear mixed modelling was used to estimate associations between the longitudinal patterns of informal caregiving (non-caregiver/one episode of 1–2 years/intermittent caregiving/3+ years caregiving) and trajectories of psychological distress across seven waves of UKHLS data. RESULTS: Informal caregiving was not associated with psychological distress for men. Women engaged in long-term (⩾3 years) or intermittent caregiving had higher levels of psychological distress at the point of initiation, compared with women who were not caregivers throughout the study period (3+ years caregiver: regression coefficient 0.48, 95% confidence interval (CI) 0.07–0.89; intermittent caregiver: regression coefficient 0.47, 95% CI 0.02–0.92). Trajectories of psychological distress changed little over time, suggesting a plateau effect for these caregiving women. CONCLUSIONS: Women engaged in long-term or repeated shorter episodes of informal caregiving reported more symptoms of psychological distress than non-caregiving women. Given the increased risk of reporting psychological distress and the increasing importance of the informal care sector, the risk of poorer mental health of informal caregivers should be a priority for public health

Crossing the road in time: Inequalities in older people's walking speeds

Pedestrian crossings in the UK and US require people to walk at 1.2 m/s to cross the road in time; however a large proportion of older people do not walk this fast, potentially discouraging walking or putting older people at risk of injury. We use longitudinal data to investigate changes in walking speed, and ability to cross the road in time, at older ages. 31,015 walking speed measurements were taken from 10,249 men and women aged 60+ years in waves 1–7 of the English Longitudinal Study of Ageing (2002–2014). Growth curve analyses were used to model how walking speed changes with increasing age, and predicted probabilities of being able to cross the road in time were estimated. 10% of measured walking speeds were fast enough to cross the road in time. Walking speed declined with age (−5.7×10$^{−3}$m/s/yr (95% CI −7.6×10$^{−3}$, −3.9×10$^{−3}$)), and the decline accelerated with increasing age (−0.3 ×10$^{−3}$m/s/yr (−0.4 ×10$^{−3}$, −0.3 ×10$^{−3}$)). Female, less wealthy and less healthy older people had slower walking speeds. For instance, predicted probability of crossing the road in time at age 60 was 14.8% (10.1, 18.5) and 2.7% (1.5, 3.8) for the richest and poorest men and 8.4% (6.0, 1.1) and 1.5% (0.9, 2.2) for the richest and poorest women, and at age 80 they were 7.1% (3.6, 10.5) and 1.0% (0.3, 1.7) for the richest and poorest men and 3.7% (1.6, 5.9) and 0.5% (0.1, 0.9) for the richest and poorest women. Most older people do not walk fast enough to cross the road in time. Even the majority of the wealthiest and healthiest people aged 60 years and older do not walk fast enough to cross pedestrian crossings in the allocated time. Crossing times should be increased to allow for older peoples’ slower walking speeds or other policies considered to improve walkability, and to help avoid injuries and social isolation.This work was supported by the UK Economic and Social Research Council (grant number ES/J019119/1 to EW), the European Research Council (grant number ERC-StG-2012-309337 to SB and ERC-2011-StG_20101124 to RL) and the UK Medical Research Council/Alcohol Research UK (grant number MR/M006638/1 to SB)

Using the theory of planned behaviour as a process evaluation tool in randomised trials of knowledge translation strategies : A case study from UK primary care

Peer reviewedPublisher PD

Atomic transition frequencies, isotope shifts, and sensitivity to variation of the fine structure constant for studies of quasar absorption spectra

Theories unifying gravity with other interactions suggest spatial and temporal variation of fundamental "constants" in the Universe. A change in the fine structure constant, alpha, could be detected via shifts in the frequencies of atomic transitions in quasar absorption systems. Recent studies using 140 absorption systems from the Keck telescope and 153 from the Very Large Telescope, suggest that alpha varies spatially. That is, in one direction on the sky alpha seems to have been smaller at the time of absorption, while in the opposite direction it seems to have been larger. To continue this study we need accurate laboratory measurements of atomic transition frequencies. The aim of this paper is to provide a compilation of transitions of importance to the search for alpha variation. They are E1 transitions to the ground state in several different atoms and ions, with wavelengths ranging from around 900 - 6000 A, and require an accuracy of better than 10^{-4} A. We discuss isotope shift measurements that are needed in order to resolve systematic effects in the study. The coefficients of sensitivity to alpha-variation (q) are also presented.Comment: Includes updated version of the "alpha line" lis

Relevant prior knowledge moderates the effect of elaboration during small group discussion on academic achievement

This study set out to test whether relevant prior knowledge would moderate a positive effect on academic achievement of elaboration during small-group discussion. In a 2 × 2 experimental design, 66 undergraduate students observed a video showing a small-group problem-based discussion about thunder and lightning. In the video, a teacher asked questions to the observing participants. Participants either elaborated by responding to these questions, or did not elaborate, but completed a

Rewarding patient-directed research: Excellence in Translational Medicine Award

The Editorial Board of Journal of Translational Medicine is pleased to announce a prize to recognize outstanding contributions in the field of translational medicine. The prize is sponsored by Pfizer Global Research and Development, Global Translational Medicine and supported by the Journal of Translational Medicine Editorial Board

Ensembles of jittered association rule classifiers

The ensembling of classifiers tends to improve predictive accuracy. To obtain an ensemble with N classifiers, one typically needs to run N learning processes. In this paper we introduce and explore Model Jittering Ensembling, where one single model is perturbed in order to obtain variants that can be used as an ensemble. We use as base classifiers sets of classification association rules. The two methods of jittering ensembling we propose are Iterative Reordering Ensembling (IRE) and Post Bagging (PB). Both methods start by learning one rule set over a single run, and then produce multiple rule sets without relearning. Empirical results on 36 data sets are positive and show that both strategies tend to reduce error with respect to the single model association rule classifier. A bias–variance analysis reveals that while both IRE and PB are able to reduce the variance component of the error, IRE is particularly effective in reducing the bias component. We show that Model Jittering Ensembling can represent a very good speed-up w.r.t. multiple model learning ensembling. We also compare Model Jittering with various state of the art classifiers in terms of predictive accuracy and computational efficiency.This work was partially supported by FCT project Rank! (PTDC/EIA/81178/2006) and by AdI project Palco3.0 financed by QREN and Fundo Europeu de Desenvolvimento Regional (FEDER), and also supported by Fundacao Ciencia e Tecnologia, FEDER e Programa de Financiamento Plurianual de Unidades de I & D. Thanks are due to William Cohen for kindly providing the executable code for the SLIPPER implementation. Our gratitude goes also to our anonymous reviewers who have helped to significantly improve this paper by sharing their knowledge and their informed criticism with the authors