Modular hybrid total hip arthroplasty. Experimental study in dogs

Background: This prospective experimental study evaluated the surgical procedure and results of modular hybrid total hip arthroplasty in dogs.Methods: Ten skeletally mature healthy mongrel dogs with weights varying between 19 and 27 kg were used. Cemented modular femoral stems and uncemented porous-coated acetabular cups were employed. Clinical and radiographic evaluations were performed before surgery and at 30, 60, 90, 120, 180 and 360 days post-operation.Results: Excellent weight bearing was noticed in the operated limb in seven dogs. Dislocation followed by loosening of the prosthesis was noticed in two dogs, which were therefore properly treated with a femoral head osteotomy. Femoral fracture occurred in one dog, which was promptly treated with full implant removal and femoral osteosynthesis.Conclusions: The canine modular hybrid total hip arthroplasty provided excellent functionality of the operated limb

Acquired resistance to anti-EGFR mAb ICR62 in cancer cells is accompanied by an increased EGFR expression, HER-2/HER-3 signalling and sensitivity to pan HER blockers

Our results provide a novel mechanistic insight into the development of acquired resistance to EGFR antibody-based therapy in colorectal cancer cells and justify further investigations on the therapeutic benefits of pan-HER family inhibitors in the treatment of colorectal cancer patients once acquired resistance to EGFR antibody-based therapy is developed

A survey on orthopedic injuries during a marathon sled dog race

Dirsko JF von Pfeil,1,2 William D Liska,3 Stuart Nelson, Jr,4 Sabine Mann,5 Joseph J Wakshlag61Friendship Surgical Services of the Friendship Hospital for Animals, Washington, DC, 2Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI, 3Global Veterinary Specialists, Sugar Land, TX, 4The Iditarod Headquarters, Wasilla, AK, 5Department of Population Medicine, 6Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USAPurpose: This prospective observational study aimed to describe and quantify orthopedic injuries (OI) during a marathon sled dog race that led to discontinuation of racing (dropped dogs [DDs]) and to suggest potential associations with risk factors during the event.Study design: Prospective observational study.Animals: A total of 989 Nordic breed endurance sled dogs that participated in the 2011 Iditarod Sled Dog Race. Data were collected via an extensive questionnaire, medical records, and speed calculations based on Global Positioning System equipment on each dog sled. OI risk factors and DD incidence were statistically analyzed on dogs and teams completing at least half the race distance, including Student’s t-test, Pearson’s chi-squared test, Poisson regression, and various frailty analysis models as indicated. Significance was set at P<0.10 for inclusion in the models with trends established at P≤0.10 and significance declared at P<0.05.Results: Questionnaire response was 40.3%. DD incidence was 38.3%, most often due to OI (50.6%). OI occurred most frequently in the thoracic limb (43.3%) compared with pelvic limb injuries (7.3%). Increased speed was associated with fewer shoulder injuries (Ratio=0.65, P=0.03). Carpal injuries were positively related with increased conditioning distance (defined as training miles; Hazard ratio =1.61, P=0.02). The risk to become a DD decreased with every year of increased age of the dogs (Hazard ratio =0.92, P=0.03).Conclusion: OI, specifically of the shoulder and carpus, are common in marathon sled dogs. Injury risk may be speed-related and decreases with increasing age of the dog. Further study of environmental, dietary, and trail conditions in sled dog racing orthopedic research is needed.Keywords: veterinary sports medicine, endurance, canine, athlete, Iditarod, arcti