19 research outputs found
The ups and downs of drug discovery: the early history of Fidaxomicin
No full textThe path, from antibiotic compound discovery to the market, is marked by many potholes and its negotiation is often dependent on luck and persistence. Perhaps the prime example of this is the case of Tiacumicin B to Fidaxomicin®, where both parameters were critical and the path was particularly circuitous
Thiolutin inhibits utilization of glucose and other carbon sources in cells of Escherichia coli
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Mapping of two transcription mutations (tlnI and tlnII) conferring thiolutin resistance, adjacent to dnaZ and rho in Escherichia coli
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Identification of Two Putative Acyltransferase Genes Potentially Implicated in Dithiolopyrrolone Biosyntheses in Saccharothrix algeriensis NRRL B-24137
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