40 research outputs found
Suppression of GATA-3 Nuclear Import and Phosphorylation: A Novel Mechanism of Corticosteroid Action in Allergic Disease
Peter Barnes and colleagues show that corticosteroids have a potent inhibitory effect on GATA-3 via two interacting mechanisms that suppress Th2 cytokine expression. This novel mechanism of corticosteroid action may help explain the efficacy of corticosteroids in allergic diseases
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Foreign policy and globalization theory: The case of Israel
Since the early 1990s, international relations has witnessed a stimulating debate on globalization. This debate laid the foundations for globalization theory (GT), providing the tools for an empirical examination of the globalization of multiple activities: from politics and organized violence, to finance, trade and production, through culture and environmental degradation. However, examination of what appear to be the best-known works on globalization reveals that foreign policy has been virtually excluded from GT. In this context, based on what is described here as a synergistic transformationalist approach (STA) to globalization, I provide a critique of GT. The critique is geared towards examining why foreign policy hitherto has been overlooked by contemporary GT. I expose the problems this generates and address them by exploring how STA enables GT to incorporate foreign policy. I use the case of Israel heuristically to elicit how incorporating foreign policy into GT may provide a better understanding of the relationship between foreign policy and globalization. Three themes are highlighted: the role of foreign policy in inducing and reproducing globalization; determining the mutually constitutive relationship between globalization and the state; and shaping the interfacing between international politics and globalization
Understanding the Middle East peace process: a historical institutionalist approach
This article challenges the common assumption that the external actors involved in the Middle East Peace Process (MEPP) are driven either by neo-realist strategic competition or by the constraining power of domestic lobbies, or by a mixture of both. Such implicit assumptions are evident in the controversial argument of the power of the âIsrael lobbyâ as promoted by Stephen Walt and John Mearsheimer. This article argues that approaches based on such assumptions fail to explain adequately the policies adopted not only by the United States, but also by other key external actors who have been historically engaged in the MEPP â the Soviet Union and the European Union. A better explanatory framework is provided by treating the MEPP as an institution and by applying a historical institutionalist approach to the development of the MEPP, using such concepts as critical junctures, path dependence and positive feedback to analyse how the main external actors involved in the MEPP came to adopt their distinctive national approaches to the peace process. In particular, it is the responses of these actors to certain critical junctures, most notably but not exclusively to the period of the 1967 and 1973 ArabâIsraeli wars, that has had a particularly strong influence on policy formulation. For the US case, the creative policymaking of Henry Kissinger during the period after the 1973 war, which was subsequently incorporated into the US conceptualization of the MEPP, provides powerful and generally unrecognized insights into the initial puzzle identified by Walt and Mearsheimer â the consistent and almost unconditional support given to Israel by the United States despite the strategic problems this creates for broader US Middle East policy