Linear Programming Relaxations for Goldreich's Generators over Non-Binary Alphabets

Goldreich suggested candidates of one-way functions and pseudorandom generators included in $\mathsf{NC}^0$. It is known that randomly generated Goldreich's generator using $(r-1)$-wise independent predicates with $n$ input variables and $m=C n^{r/2}$ output variables is not pseudorandom generator with high probability for sufficiently large constant $C$. Most of the previous works assume that the alphabet is binary and use techniques available only for the binary alphabet. In this paper, we deal with non-binary generalization of Goldreich's generator and derives the tight threshold for linear programming relaxation attack using local marginal polytope for randomly generated Goldreich's generators. We assume that $u(n)\in \omega(1)\cap o(n)$ input variables are known. In that case, we show that when $r\ge 3$, there is an exact threshold $\mu_\mathrm{c}(k,r):=\binom{k}{r}^{-1}\frac{(r-2)^{r-2}}{r(r-1)^{r-1}}$ such that for $m=\mu\frac{n^{r-1}}{u(n)^{r-2}}$, the LP relaxation can determine linearly many input variables of Goldreich's generator if $\mu>\mu_\mathrm{c}(k,r)$, and that the LP relaxation cannot determine $\frac1{r-2} u(n)$ input variables of Goldreich's generator if $\mu<\mu_\mathrm{c}(k,r)$. This paper uses characterization of LP solutions by combinatorial structures called stopping sets on a bipartite graph, which is related to a simple algorithm called peeling algorithm.Comment: 14 pages, 1 figur

Synthesis of artificial lymphoid tissue with immunological function.

The ability to generate functional artificial lymphoid tissue to induce specific immunity at ectopic sites could offer a potential breakthrough for treatment of diseases such as cancer and severe infection using immunotherapy. Artificial lymphoid tissue could also offer an informative tool to study further lymphoid tissue development and function in vivo. Here, we review the process of secondary and tertiary lymphoid organization, of which an understanding is essential for artificial lymphoid tissue synthesis. Using this knowledge, we consider the combination of cell types, soluble factors and scaffold properties that will enable proper accumulation and organization of lymphocytes into tissue grafts. Recent success in in vivo induction of artificial lymphoid tissue are also considered