608 research outputs found

    Direct estimation of kinetic parametric images for dynamic PET.

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    Dynamic positron emission tomography (PET) can monitor spatiotemporal distribution of radiotracer in vivo. The spatiotemporal information can be used to estimate parametric images of radiotracer kinetics that are of physiological and biochemical interests. Direct estimation of parametric images from raw projection data allows accurate noise modeling and has been shown to offer better image quality than conventional indirect methods, which reconstruct a sequence of PET images first and then perform tracer kinetic modeling pixel-by-pixel. Direct reconstruction of parametric images has gained increasing interests with the advances in computing hardware. Many direct reconstruction algorithms have been developed for different kinetic models. In this paper we review the recent progress in the development of direct reconstruction algorithms for parametric image estimation. Algorithms for linear and nonlinear kinetic models are described and their properties are discussed

    Promising Role of Engineered Gene Circuits in Gene Therapy

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    Discovery of 21 New Changing-look AGNs in Northern Sky

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    The rare case of changing-look (CL) AGNs, with the appearance or disappearance of broad Balmer emission lines within a few years, challenges our understanding of the AGN unified model. We present a sample of 21 new CL AGNs at 0.08<z<0.580.08<z<0.58, which doubles the number of such objects known to date. These new CL AGNs were discovered by several ways, from (1) repeat spectra in the SDSS, (2) repeat spectra in the Large Sky Area Multi-Object Fiber Spectroscopic Telescope (LAMOST) and SDSS, and (3) photometric variability and new spectroscopic observations. We use the photometric data from surveys, including the SDSS imaging survey, the Pan-STARRS1, the DESI Legacy imaging survey, the Wide-field Infrared Survey Explorer (WISE), the Catalina Real-time Transient Survey, and the Palomar Transient Factory. The estimated upper limits of transition timescale of the CL AGNs in this sample spans from 0.9 to 13 years in the rest frame. The continuum flux in the optical and mid-infrared becomes brighter when the CL AGNs turn on, or vice versa. Variations of more than 0.2 mag in W1W1 band were detected in 15 CL AGNs during the transition. The optical and mid-infrared variability is not consistent with the scenario of variable obscuration in 10 CL AGNs at more than 3σ3\sigma confidence level. We confirm a bluer-when-brighter trend in the optical. However, the mid-infrared WISE colors W1W2W1-W2 become redder when the objects become brighter in the W1W1 band, possibly due to a stronger hot dust contribution in the W2W2 band when the AGN activity becomes stronger. The physical mechanism of type transition is important for understanding the evolution of AGNs.Comment: Accepted for publication in Ap

    A Thirty-Four Billion Solar Mass Black Hole in SMSS J2157-3602, the Most Luminous Known Quasar

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    From near-infrared spectroscopic measurements of the MgII emission line doublet, we estimate the black hole (BH) mass of the quasar, SMSS J215728.21-360215.1, as being (3.4 +/- 0.6) x 10^10 M_sun and refine the redshift of the quasar to be z=4.692. SMSS J2157 is the most luminous known quasar, with a 3000A luminosity of (4.7 +/- 0.5) x 10^47 erg/s and an estimated bolometric luminosity of 1.6 x 10^48 erg/s, yet its Eddington ratio is only ~0.4. Thus, the high luminosity of this quasar is a consequence of its extremely large BH -- one of the most massive BHs at z > 4.Comment: 7 pages, 3 figures. Accepted for publication in MNRA

    PCToolkit: A Unified Plug-and-Play Prompt Compression Toolkit of Large Language Models

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    Prompt compression is an innovative method for efficiently condensing input prompts while preserving essential information. To facilitate quick-start services, user-friendly interfaces, and compatibility with common datasets and metrics, we present the Prompt Compression Toolkit (PCToolkit). This toolkit is a unified plug-and-play solution for compressing prompts in Large Language Models (LLMs), featuring cutting-edge prompt compressors, diverse datasets, and metrics for comprehensive performance evaluation. PCToolkit boasts a modular design, allowing for easy integration of new datasets and metrics through portable and user-friendly interfaces. In this paper, we outline the key components and functionalities of PCToolkit. We conducted evaluations of the compressors within PCToolkit across various natural language tasks, including reconstruction, summarization, mathematical problem-solving, question answering, few-shot learning, synthetic tasks, code completion, boolean expressions, multiple choice questions, and lies recognition.Comment: For open-source repository, see https://github.com/3DAgentWorld/Toolkit-for-Prompt-Compressio

    The concept of human nature in Wei-Jin Chinese philosophy

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    Ph.DDOCTOR OF PHILOSOPH

    A Survey for High-redshift Gravitationally Lensed Quasars and Close Quasars Pairs. I. the Discoveries of an Intermediately-lensed Quasar and a Kpc-scale Quasar Pair at z5z\sim5

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    We present the first results from a new survey for high-redshift (z5)(z\gtrsim5) gravitationally lensed quasars and close quasar pairs. We carry out candidate selection based on the colors and shapes of objects in public imaging surveys, then conduct follow-up observations to confirm the nature of high-priority candidates. In this paper, we report the discoveries of J0025--0145 (z=5.07z=5.07) which we identify as an {intermediately-lensed quasar, and J2329--0522 (z=4.85z=4.85) which is a kpc-scale close quasar pair. The {\em Hubble Space Telescope (HST)} image of J0025--0145 shows a foreground lensing galaxy located 0\farcs6 away from the quasar. However, J0025--0145 does not exhibit multiple lensed images of the quasar, and we identify J0025--0145 as an intermediate lensing system (a lensing system that is not multiply imaged but has a significant magnification). The spectrum of J0025--0145 implies an extreme Eddington ratio if the quasar luminosity is intrinsic, which could be explained by a large lensing magnification. The {\em HST} image of J0025--0145 also indicates a tentative detection of the quasar host galaxy in rest-frame UV, illustrating the power of lensing magnification and distortion in studies of high-redshift quasar host galaxies. J2329--0522 consists of two resolved components with significantly different spectral properties, and a lack of lensing galaxy detection under sub-arcsecond seeing. We identify it as a close quasar pair, which is the highest confirmed kpc-scale quasar pair to date. We also report four lensed quasars and quasar pairs at 2<z<42<z<4, and discuss possible improvements to our survey strategy.Comment: 23 pages, 10 figures, 6 tables. Accepted by the Astronomical Journa
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