PDGF-B gene therapy accelerates bone engineering and oral implant osseointegration

Platelet-derived growth factor-BB (PDGF-BB) stimulates repair of healing-impaired chronic wounds such as diabetic ulcers and periodontal lesions. However, limitations in predictability of tissue regeneration occur due, in part, to transient growth factor bioavailability in vivo. Here, we report that gene delivery of PDGF-B stimulates repair of oral implant extraction socket defects. Alveolar ridge defects were created in rats and were treated at the time of titanium implant installation with a collagen matrix containing an adenoviral (Ad) vector encoding PDGF-B (5.5 x 10(8) or 5.5 x 10(9) pfu ml(-1)), Ad encoding luciferase (Ad-Luc; 5.5 x 10(9) pfu ml(-1); control) or recombinant human PDGF-BB protein (rhPDGF-BB, 0.3 mg ml(-1)). Bone repair and osseointegration were measured through backscattered scanning electron microscopy, histomorphometry, micro-computed tomography and biomechanical assessments. Furthermore, a panel of local and systemic safety assessments was performed. Results indicated that bone repair was accelerated by Ad-PDGF-B and rhPDGF-BB delivery compared with Ad-Luc, with the high dose of Ad-PDGF-B more effective than the low dose. No significant dissemination of the vector construct or alteration of systemic parameters was noted. In summary, gene delivery of Ad-PDGF-B shows regenerative and safety capabilities for bone tissue engineering and osseointegration in alveolar bone defects comparable with rhPDGF-BB protein delivery in vivo

Industry/University Collaboration at the University of Michigan-Dearborn: A Focus on Relevant Technology

https://deepblue.lib.umich.edu/bitstream/2027.42/154106/1/kampfner1998.pd

Functional assessment of dental implant osseointegration.

The International journal of periodontics & restorative dentistry325e147-15

Location Based Logistics Services and Event Driven Business Process Management

Location-based Services (LBS) [1] have already started their market penetration process and several platforms capable of running LBS are available. With the number of LBS increasing, the current development is targeting consumer applications, although LBS have a high potential for enhancing business processes in companies as well. Considering business process optimization, one concept recently discussed in the field of Business Process Management (BPM) [2] is Event-Driven Business Process Management (ED-BPM) [3], which combines Business Process Management (BPM) and Complex Event Processing (CEP) [4]. This paper introduces ED-BPM for LBS in the logistics field, exemplifying its potential use with an example for a logistics order process execution

Numerical study of coal dust behaviours and experimental investigation on coal dust suppression efficiency of surfactant solution by using wind tunnel tests

Coal dust is one of the most serious hazards on mine sites. Water spray with surfactant added is an effective way to control the coal dust. In this study, wind tunnel experiments were designed to evaluate the surfactant on coal dust suppression efficiency. A CFD modeling was first constructed in to investigate the coal dust particles movement characteristics, and the stimulation results were provided for the wind tunnel design. The CFD results indicated that the location of the nozzle placement and the time for the water spraying start time. The coal dust suppression efficiency was then evaluated in the presence of different surfactants. The experiment results suggest that the anionic and non-ionic surfactants are helpful to improve the suppression efficiency while the cationic surfactant failed to increase it. For the SDBS at various concentrations, the highest suppression efficiency is achieved when at 0.20%. Compared with the larger coal dust particles, the finer ones are more difficult to capture for both water and SDBS surfactant solution. The results also demonstrate the potential application of this surfactant on coal mine industries