Altered levels of blood proteins in Alzheimer\u27s disease longitudinal study: Results from Australian Imaging Biomarkers Lifestyle Study of Ageing cohort

Introduction A blood-based biomarker panel to identify individuals with preclinical Alzheimer\u27s disease (AD) would be an inexpensive and accessible first step for routine testing. Methods We analyzed 14 biomarkers that have previously been linked to AD in the Australian Imaging Biomarkers lifestyle longitudinal study of aging cohort. Results Levels of apolipoprotein J (apoJ) were higher in AD individuals compared with healthy controls at baseline and 18 months (P =.0003) and chemokine-309 (I-309) were increased in AD patients compared to mild cognitive impaired individuals over 36 months (P =.0008). Discussion These data suggest that apoJ may have potential in the context of use (COU) of AD diagnostics, I-309 may be specifically useful in the COU of identifying individuals at greatest risk for progressing toward AD. This work takes an initial step toward identifying blood biomarkers with potential use in the diagnosis and prognosis of AD and should be validated across other prospective cohorts. © 2017 The Author

Little evidence of subclinical avian influenza virus infections among rural villagers in Cambodia

10.1371/journal.pone.0097097PLoS ONE95e9709

The Rosetta Stone methodology – a benefits-driven approach to SPI

The Rosetta Stone Methodology (RSM) has been developed which allows organizations to undertake Software Process Improvement (SPI) based on business- and organizational-driven goals and objectives. The methodology itself is fully customizable and allows organizations to make adjustments to the model where they feel it appropriate. To demonstrate the usefulness, appropriateness and practicality of this new approach, the Rosetta Stone IGSIISM to CMMI Instance mapping (RS-ICMMI) is developed. To aid in understanding, the Measurement and Analysis (MA) process area is used as an example of how to apply the methodology. The Rosetta Stone Methodology and the RS-ICMMI instance have been validated by experts

Prospective Study of Avian Influenza Virus Infections among Rural Thai Villagers

10.1371/journal.pone.0072196PLoS ONE88e7219

High rate of A(H1N1)pdm09 infections among rural Thai villagers, 2009-2010

10.1371/journal.pone.0106751PLoS ONE99e10675