129 research outputs found
Topological (Sliced) Doping of a 3D Peierls System: Predicted Structure of Doped BaBiO3
At hole concentrations below x=0.4, Ba_(1-x)K_xBiO_3 is non-metallic. At x=0,
pure BaBiO3 is a Peierls insulator. Very dilute holes create bipolaronic point
defects in the Peierls order parameter. Here we find that the Rice-Sneddon
version of Peierls theory predicts that more concentrated holes should form
stacking faults (two-dimensional topological defects, called slices) in the
Peierls order parameter. However, the long-range Coulomb interaction, left out
of the Rice-Sneddon model, destabilizes slices in favor of point bipolarons at
low concentrations, leaving a window near 30% doping where the sliced state is
marginally stable.Comment: 6 pages with 5 embedded postscript figure
Stellar evolution and modelling stars
In this chapter I give an overall description of the structure and evolution
of stars of different masses, and review the main ingredients included in
state-of-the-art calculations aiming at reproducing observational features. I
give particular emphasis to processes where large uncertainties still exist as
they have strong impact on stellar properties derived from large compilations
of tracks and isochrones, and are therefore of fundamental importance in many
fields of astrophysics.Comment: Lecture presented at the IVth Azores International Advanced School in
Space Sciences on "Asteroseismology and Exoplanets: Listening to the Stars
and Searching for New Worlds" (arXiv:1709.00645), which took place in Horta,
Azores Islands, Portugal in July 201
The small heat shock protein Hsp27 binds α-synuclein fibrils, preventing elongation and cytotoxicity
Proteostasis, or protein homeostasis, encompasses the maintenance of the conformational and functional integrity of the proteome and involves an integrated network of cellular pathways. Molecular chaperones, such as the small heat shock proteins (sHsps), are key elements of the proteostasis network that have crucial roles in inhibiting the aggregation of misfolded proteins. Failure of the proteostasis network can lead to the accumulation of misfolded proteins into intracellular and extracellular deposits. Deposits containing fibrillar forms of α-sy-nuclein (α-syn) are characteristic of neurodegenerative disorders including Parkinson\u27s disease and dementia with Lewy bodies. Here we show that the sHsp Hsp27 (HSPB1) binds to α-syn fibrils, inhibiting fibril growth by preventing elongation. Using total internal reflection fluorescence (TIRF)- based imaging methods, we show that Hsp27 binds along the surface of α-syn fibrils, decreasing their hydrophobicity. Binding of Hsp27 also inhibits cytotoxicity of α-syn fibrils. Our results demonstrate that the ability of sHsps, such as Hsp27, to bind fibrils represents an important mechanism through which they May mitigate cellular toxicity associated with aberrant protein aggregation. Fibril binding May represent a generic mechanism by which chaperone-active sHsps interact with aggregation-prone proteins, highlighting the potential to target sHsp activity to prevent or disrupt the onset and progression of α-syn aggregation associated with α-synucleinopathies
Trends in the Statistical Assessment of Reliability
Changes in technology have had and will continue to have a strong effect on changes in the area of statistical assessment of reliability data. These changes include higher levels of integration in electronics, improvements in measurement technology and the deployment of sensors and smart chips into more products, dramatically improved computing power and storage technology, and the development of new, powerful statistical methods for graphics, inference, and experimental design and reliability test planning. This paper traces some of the history of the development of statistical methods for reliability assessment and makes some predictions about the future
WGS-based telomere length analysis in Dutch family trios implicates stronger maternal inheritance and a role for RRM1 gene
Telomere length (TL) regulation is an important factor in ageing, reproduction and cancer development. Genetic, hereditary and environmental factors regulating TL are currently widely investigated, however, their relative contribution to TL variability is still understudied. We have used whole genome sequencing data of 250 family trios from the Genome of the Netherlands project to perform computational measurement of TL and a series of regression and genome-wide association analyses to reveal TL inheritance patterns and associated genetic factors. Our results confirm that TL is a largely heritable trait, primarily with mother’s, and, to a lesser extent, with father’s TL having the strongest influence on the offspring. In this cohort, mother’s, but not father’s age at conception was positively linked to offspring TL. Age-related TL attrition of 40 bp/year had relatively small influence on TL variability. Finally, we have identified TL-associated variations in ribonuclease reductase catalytic subunit M1 (RRM1 gene), which is known to regulate telomere maintenance in yeast. We also highlight the importance of multivariate approach and the limitations of existing tools for the analysis of TL as a polygenic heritable quantitative trait
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