7 research outputs found
EficĂĄcia das lactonas macrocĂclicas sistĂȘmicas (ivermectina e moxidectina) na terapia da demodicidose canina generalizada Efficacy of systemics macrocyclic lactones (ivermectin and moxidectin) for the treatment of generalized canine demodicosis
Avaliou-se a eficĂĄcia de lactonas macrocĂclicas (ivermectina e moxidectina) sobre a eventual ocorrĂȘncia de efeitos colaterais e acompanharam-se, apĂłs a alta parasitolĂłgica, por 12 meses, os cĂŁes tratados, visando detectar a recidiva do quadro dermatopĂĄtico. Dos 63 animais, 59% eram fĂȘmeas, 76% apresentavam precisa definição racial e 67% tinham pelame curto. A ivermectina (0,6mg/kg/dia) foi administrada por via oral a 31 cĂŁes, e a moxidectina (0,5mg/kg/cada 72 horas), pela mesma via, a 32 animais. Os tempos mĂ©dios para a obtenção da primeira negativação do exame parasitolĂłgico do raspado cutĂąneo e para a consecução da alta foram, respectivamente, de 90 e 130 dias para a ivermectina e de 108 e 147 dias para a moxidectina. A ivermectina acarretou menos (16,1%) efeitos colaterais em relação Ă moxidectina (37,5%) (P=0,03). As recidivas foram, respectivamente, 10,3% e 13% para ivermectina e moxidectina. NĂŁo houve diferença entre os dois protocolos de terapia quanto aos percentuais de recidiva (P=0,67) e eficĂĄcia (P=0,61). Ambas as lactonas macrocĂclicas mostraram-se eficazes: ivermectina 89,7% e moxidectina 87%.<br>The efficacy of ivermectin and moxidectin for treatment of generalized canine demodicosis, was evaluated to detect the eventual occurrence of side effects caused by the use of these drugs, and to follow the treated dogs for 12 months after obtaining parasitologic cure. Of 63 dogs, 59% were females, 76% were defined as purebred and 67% had short hair. Ivermectin (0.6mg/kg/daily) was orally administered to 31 dogs and moxidectin (0.5mg/kg/every 72 hours) to 32 dogs. The average number of days to obtain the first negative skin scraping results and the parasitologic cure were, respectively, 90 and 130 days for ivermectin, and 108 and 147 days for moxidectin. Ivermectin caused fewer side effects (16.1%) than moxidectin (37.5%) (P<0.05). The percentages of relapse were, respectively, 10.3% and 13.0% when ivermectin and moxidectin were administered. No difference between protocols of therapy was found for percentage of relapse (P>0.67) and efficacy (P>0.61). Both drugs were effective and safe to treat generalized canine demodicosis: ivermectin 89.7% and moxidectin 87.0%