Prostaglandin-Induced Resorption of the Adult Rat Calvarium

Prostaglandin E1-containing solutions injected under the skin overlying the calvarium of adult rats produced a visible resorptive lesion within the bone in seven days. The resorptive process was characterized by fibrous replacement of bone matrix and by increased vascularity. Inflammatory cells were not apparent.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/67319/2/10.1177_00220345740530032601.pd