79 research outputs found
A Transport and Microwave Study of Superconducting and Magnetic RuSr2EuCu2O8
We have performed susceptibility, thermopower, dc resistance and microwave
measurements on RuSr2EuCu2O8. This compound has recently been shown to display
the coexistence of both superconducting and magnetic order. We find clear
evidence of changes in the dc and microwave resistance near the magnetic
ordering temperature (132 K). The intergranular effects were separated from the
intragranular effects by performing microwave measurements on a sintered
ceramic sample as well as on a powder sample dispersed in an epoxy resin. We
show that the data can be interpreted in terms of the normal-state resistivity
being dominated by the CuO2 layers with exchange coupling to the Ru moments in
the RuO2 layers. Furthermore, most of the normal-state semiconductor-like
upturn in the microwave resistance is found to arise from intergranular
transport. The data in the superconducting state can be consistently
interpreted in terms of intergranular weak-links and an intragranular
spontaneous vortex phase due to the ferromagnetic component of the
magnetization arising from the RuO2 planes.Comment: 20 pages including 6 figures in pdf format. To be published in Phys.
Rev.
Is the inflammasome a potential therapeutic target in renal disease?
The inflammasome is a large, multiprotein complex that drives proinflammatory cytokine production in response to infection and tissue injury. Pattern recognition receptors that are either membrane bound or cytoplasmic trigger inflammasome assembly. These receptors sense danger signals including damage-associated molecular patterns and pathogen-associated molecular patterns (DAMPS and PAMPS respectively). The best-characterized inflammasome is the NLRP3 inflammasome. On assembly of the NLRP3 inflammasome, post-translational processing and secretion of pro-inflammatory cytokines IL-1β and IL-18 occurs; in addition, cell death may be mediated via caspase-1. Intrinsic renal cells express components of the inflammasome pathway. This is most prominent in tubular epithelial cells and, to a lesser degree, in glomeruli. Several primary renal diseases and systemic diseases affecting the kidney are associated with NLRP3 inflammasome/IL-1β/IL-18 axis activation. Most of the disorders studied have been acute inflammatory diseases. The disease spectrum includes ureteric obstruction, ischaemia reperfusion injury, glomerulonephritis, sepsis, hypoxia, glycerol-induced renal failure, and crystal nephropathy. In addition to mediating renal disease, the IL-1/ IL-18 axis may also be responsible for development of CKD itself and its related complications, including vascular calcification and sepsis. Experimental models using genetic deletions and/or receptor antagonists/antiserum against the NLRP3 inflammasome pathway have shown decreased severity of disease. As such, the inflammasome is an attractive potential therapeutic target in a variety of renal diseases
THEORY OF THERMAL CONDUCTIVITY IN MOLECULAR CRYSTALS, APPLICATION TO ALCALI CYANIDES
We investigate the influence of coupling between translational and rotational motion on the thermal conductivity of molecular crystals and present results for KCN
Verteilung von Klebsiella pneumoniae-Serotypen unterschiedlicher Herkunft und deren Empfindlichkeit gegenüber Cephalosporinen
Roles of β-Lactamases and Porins in Activities of Carbapenems and Cephalosporins against Klebsiella pneumoniae
Mayfly ecological traits in a European karst spring: species, microhabitats and life histories
beta-Lactam-resistant Pseudomonas aeruginosa with modified penicillin-binding proteins emerging during cystic fibrosis treatment
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