Prospectus, November 7, 1984

KROHN MOVES FORWARD IN HER QUEST FOR LIFE…WE\u27LL MISS YOU; Veterans Day-1984; PC Happenings; Programs aid parents of pre-schoolers; Speaking Cobras take 4th; Classic presented in Parkland Theatre; Medicare workshop gives assistance; Talent auditions for \u2785 season for Busch Gardens; McDermott enjoys helping students gain knowlegde; Did You Know...; Classifieds; Creative Corner...especially for you!; Doom Story...the end draws near; Its over way before its over; Trial; I Love...; i\u27m content; divorces; self destruction; Pointless; Forty and Proud; anonymous; No More; my prison; the invisible wall; Dear Church street,; ?Blessing?; The Torch Bearers; these rooms; Still There; Koontz strikes again; Field plays greatest role; Elton John reborn; Creativity flowers in adverse conditions; Look out Belleville...here we come, and we bad!!!; Hard work pays off for Deany, Edwards; Workshop on memory disorders; Urbanek\u27s defense spearheads Hit Men to IM championship; Four Cobras advance to Nationalshttps://spark.parkland.edu/prospectus_1984/1005/thumbnail.jp

Current strategies for treatment of intervertebral disc degeneration: substitution and regeneration possibilities

Background: Intervertebral disc degeneration has an annual worldwide socioeconomic impact masked as low back pain of over 70 billion euros. This disease has a high prevalence over the working age class, which raises the socioeconomic impact over the years. Acute physical trauma or prolonged intervertebral disc mistreatment triggers a biochemical negative tendency of catabolic-anabolic balance that progress to a chronic degeneration disease. Current biomedical treatments are not only ineffective in the long-run, but can also cause degeneration to spread to adjacent intervertebral discs. Regenerative strategies are desperately needed in the clinics, such as: minimal invasive nucleus pulposus or annulus fibrosus treatments, total disc replacement, and cartilaginous endplates decalcification. Main Body: Herein, it is reviewed the state-of-the-art of intervertebral disc regeneration strategies from the perspective of cells, scaffolds, or constructs, including both popular and unique tissue engineering approaches. The premises for cell type and origin selection or even absence of cells is being explored. Choice of several raw materials and scaffold fabrication methods are evaluated. Extensive studies have been developed for fully regeneration of the annulus fibrosus and nucleus pulposus, together or separately, with a long set of different rationales already reported. Recent works show promising biomaterials and processing methods applied to intervertebral disc substitutive or regenerative strategies. Facing the abundance of studies presented in the literature aiming intervertebral disc regeneration it is interesting to observe how cartilaginous endplates have been extensively neglected, being this a major source of nutrients and water supply for the whole disc. Conclusion: Severalinnovative avenues for tackling intervertebral disc degeneration are being reported â from acellular to cellular approaches, but the cartilaginous endplates regeneration strategies remain unaddressed. Interestingly, patient-specific approaches show great promise in respecting patient anatomy and thus allow quicker translation to the clinics in the near future.The authors would like to acknowledge the support provided by the Portuguese Foundation for Science and Technology (FCT) through the project EPIDisc (UTAP-EXPL/BBBECT/0050/2014), funded in the Framework of the “International Collaboratory for Emerging Technologies, CoLab”, UT Austin|Portugal Program. The FCT distinctions attributed to J. Miguel Oliveira (IF/00423/2012 and IF/01285/ 2015) and J. Silva-Correia (IF/00115/2015) under the Investigator FCT program are also greatly acknowledged.info:eu-repo/semantics/publishedVersio

A General Small-Scale Reactor To Enable Standardization and Acceleration of Photocatalytic Reactions

Photocatalysis for organic synthesis has experienced an exponential growth in the past 10 years. However, the variety of experimental procedures that have been reported to perform photon-based catalyst excitation has hampered the establishment of general protocols to convert visible light into chemical energy. To address this issue, we have designed an integrated photoreactor for enhanced photon capture and catalyst excitation. Moreover, the evaluation of this new reactor in eight photocatalytic transformations that are widely employed in medicinal chemistry settings has confirmed significant performance advantages of this optimized design while enabling a standardized protocol