Lawinen-Photodetektoren auf der Basis von III-V Verbindungs-Halbleitern fuer die optische Nachrichtentechnnik Abschlussbericht. Abschlussdatum: Maerz 1982

TIB: AC 8128 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman

Photonik II - Optische Millimeterwellenverbindungen. Optisches 60 GHz Millimeterwellen-System Schlussbericht

Optical millimeterwave systems offer a new application area for advanced photonic technologies and represent an important interface between radio based networks and optical broadband communication networks. Main objectives of this project were the investigation and realisation of novel methods and subsystems for the generation, fiber based transmission or distribution and for efficient optoelectronic conversion of optical millimeterwave carriers at frequencies around 60 GHz for the transport of broadband signals over hybrid fiber-radio (HFR) networks. HFR systems offer attractive options for broadband wireless local loop (BWLL) applications and cellular broadband information systems. Within this project has been demonstrated worldwide for the first time in the field the transport of broadband signal channels (3-140 Mbit/s) via 60 GHz optical millimeterwave carriers over hybrid fiber radio networks including G.652 fiber feeder lengths of more than 100 km. Further has been realised for the first time a compact hybrid-integrated o/e 60 GHz antenna base station, including high speed photodiode, MMIC amplifier and planar antenna. (orig.)SIGLEAvailable from TIB Hannover: DtF QN1(74,22) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekBundesministerium fuer Bildung, Wissenschaft, Forschung und Technologie, Bonn (Germany)DEGerman

900 MHz pulse-width-modulated class-S power amplifier with improved linearity

The following paper presents a novel 900MHz pulse-width-modulated current-mode class-S power amplifier. The conversion from an analog to a digital signal, which can be handled by the subsequent switch-mode-stage, is implemented using a fast pulse-width-modulator. The complete class-S amplifier is characterized using clipped WCDMA signals with 5MHz and 80MHz bandwidth, respectively. For the 5MHz signal, the measured spectrum at the amplifier's output shows good EVM of < 12% (approx. 1.5% degradation assumed for class-S PA) and also meets the 3GPP ACLR requirements within 9dB input power range. The capability to support large signal bandwidths is demonstrated, using an 80MHz WCDMA signal, thus meeting the expectations on class-S amplifier for the first time with respect to signal bandwidth

MiR-34a is differentially expressed in dorsal root ganglia in a rat model of chronic neuropathic pain

Introduction: Recent evidence shows that numerous microRNAs (miRNAs) regulate pain-related genes in chronic pain. The aim of the present study was to further explore the regulation of miRNAs and their effect on the expression of pain-associated target genes in experimental neuropathic pain. Methods: Male Wistar rats underwent chronic constriction injury (CCI) of the sciatic nerve or Sham procedure. After assessment of mechanical allodynia, the ipsilateral dorsal root ganglia (DRG) were harvested. MiRNA expression levels were analysed with Agilent microRNA microarrays and real time quantitative PCR. An interaction between miRNAs and pain-relevant genes was confirmed by luciferase assays. Western Blot analysis and ELISA were performed to evaluate protein expression, respectively. Results: Mechanical allodynia developed within 6 days after CCI. MiRNA-arrays revealed the differential expression of 49 miRNAs after 4 h, of 3 miRNAs after 1 d, of 26 miRNAs after 6 d and of 28 miRNAs after 12 d in the CCI group versus Sham. Time-dependent down regulation of miR-34a was verified by qPCR. Bioinformatic prediction revealed an interaction with several pain-relevant targets including voltage-gated sodium channel β2 subunit (SCN2B) and vesicle-associated membrane protein 2 (VAMP-2), both of which were subsequently confirmed by luciferase assay. VAMP-2 expression was statistically significantly increased 12 d after CCI. A non-significant upregulation of SCN2B in the DRG after CCI was confirmed by ELISA. Discussion: Peripheral mononeuropathic pain in rats was associated with distinct alterations of miRNA expression in the ipsilateral DRG. Notably, miR-34a was time-dependently down regulated. We validated SCN2B and VAMP-2 as new targets of miR-34a. While SCN2B expression was only marginally altered, VAMP-2 expression was increased. The present study underlines that the induction and maintenance of neuropathic pain is accompanied by expression changes of miRNAs in the peripheral nervous system, adding several previously unreported miRNAs, including miR-34a

Photodetektoren fuer die langwellige optische Nachrichtenuebertragung Schlussbericht

With 114 refs., 4 tabs., 77 figs.SIGLECopy held by FIZ Karlsruhe; available from UB/TIB Hannover / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekDEGerman

Overview of the Third International Workshop on Swine Leukocyte Differentiation Antigens

The aim of the Third International Workshop on Swine Leukocyte Differentiation Antigens (CD workshop), supported by the Veterinary Immunology Committee (VIC) of the International Union of Immunological Societies (IUIS), was to standardize the assignment of monoclonal antibodies (mAb) reactive with porcine leukocyte differentiation antigens and to define new antibody clusters, using nomenclature in accordance with human and ruminant CD nomenclature, as agreed at the summary meeting of the Second International Swine CD Workshop in Davis, 1995: only mAb with proven reactivity for the orthologous porcine gene product or cross-reactivity for the human gene products, were given the full CD nomenclature, all other allocations were prefixed with 'w'.As in previous workshops, the overall organization was entrusted to the chair and first author, with support by the chair of the previous workshop and second author.In addition to the existing 26 pig leukocyte CD/SWC determinants established in previous workshops, this workshop established/confirmed another 11 CDs for pig leukocytes, identified by a total of 21 mAb: CD11R1 (2 mAb), CD11R2 (1 mAb), CD11R3 (4 mAb), wCD40 (1 mAb), wCD46 (4 mAb), wCD47 (3 mAb), wCD49d (1 mAb), CD61 (1 mAb), wCD92 (1 mAb), wCD93 (1 mAb) and CD163 (2 mAb). Copyrigh

Overview of the Third International Workshop on Swine Leukocyte Differentiation Antigens

The aim of the Third International Workshop on Swine Leukocyte Differentiation Antigens (CD workshop), supported by the Veterinary Immunology Committee (VIC) of the International Union of Immunological Societies (IUIS), was to standardize the assignment of monoclonal antibodies (mAb) reactive with porcine leukocyte differentiation antigens and to define new antibody clusters, using nomenclature in accordance with human and ruminant CD nomenclature, as agreed at the summary meeting of the Second International Swine CD Workshop in Davis, 1995 only mAb with proven reactivity for the orthologous porcine gene product or cross-reactivity for the human gene products, were given the full CD nomenclature, all other allocations were prefixed with 'w'.As in previous workshops, the overall organization was entrusted to the chair and first author, with support by the chair of the previous workshop and second author.In addition to the existing 26 pig leukocyte CD/SWC determinants established in previous workshops, this workshop established/confirmed another 11 CDs for pig leukocytes, identified by a total of 21 mAb CD11R1 (2 mAb), CD11R2 (1 mAb), CD11R3 (4 mAb), wCD40 (1 mAb), wCD46 (4 mAb), wCD47 (3 mAb), wCD49d (1 mAb), CD61 (1 mAb), wCD92 (1 mAb), wCD93 (1 mAb) and CD163 (2 mAb). Copyright © 2001 Elsevier Science B.V