The efficiency of education in generating literacy: a stochastic frontier approach

The growing importance attached to education as a key factor to improve economic performance coupled with the persistent scarcity of resources for education makes it important that skills and literacy are produced efficiently. This paper provides an international comparison of the efficiency of literacy production. We find substantial differences between countries in levels of literacy, differences in literacy between education levels and differences in the efficiency of literacy production. There are some notable differences between more Anglo-Saxon countries and the Continental European countries. The findings suggest that in almost all countries the scope for efficiency improvements in education is large. So even without major increases in (public) funding, improvements in educational outcomes are achievable. We can get better value for the money we spend on education.

X-ray Halos and Large Grains in the Diffuse Interstellar Medium

Recent observations with dust detectors on board the interplanetary spacecraft Ulysses and Galileo have recorded a substantial flux of large interstellar grains with radii between 0.25 and 2.0 mu entering the solar system from the local interstellar cloud. The most commonly used interstellar grain size distribution is characterized by a a^-3.5 power law in grain radii a, and extends to a maximum grain radius of 0.25 mu. The extension of the interstellar grain size distribution to such large radii will have a major effect on the median grain size, and on the amount of mass needed to be tied up in dust for a given visual optical depth. It is therefore important to investigate whether this population of larger dust particles prevails in the general interstellar medium, or if it is merely a local phenomenon. The presence of large interstellar grains can be mainly inferred from their effect on the intensity and radial profiles of scattering halos around X-ray sources. In this paper we examine the grain size distribution that gives rise to the X-ray halo around Nova Cygni 1992. The results of our study confirm the need to extend the interstellar grain size distribution in the direction of this source to and possibly beyond 2.0 mu. The model that gives the best fit to the halo data is characterized by: (1) a grain size distribution that follows an a^-3.5 power law up to 0.50 mu, followed by an a^-4.0 extension from 0.50 mu to 2.0 mu; and (2) silicate and graphite (carbon) dust-to-gas mass ratios of 0.0044 and 0.0022, respectively, consistent with solar abundances constraints. Additional observations of X-ray halos probing other spatial directions are badly needed to test the general validity of this result.Comment: 17 pages, incl. 1 figure, accepted for publ. by ApJ Letter

A self-consistent perturbative evaluation of ground state energies: application to cohesive energies of spin lattices

The work presents a simple formalism which proposes an estimate of the ground state energy from a single reference function. It is based on a perturbative expansion but leads to non linear coupled equations. It can be viewed as well as a modified coupled cluster formulation. Applied to a series of spin lattices governed by model Hamiltonians the method leads to simple analytic solutions. The so-calculated cohesive energies are surprisingly accurate. Two examples illustrate its applicability to locate phase transition.Comment: Accepted by Phys. Rev.

Numerical Investigation of a Mesoscopic Vehicular Traffic Flow Model Based on a Stochastic Acceleration Process

In this paper a spatial homogeneous vehicular traffic flow model based on a stochastic master equation of Boltzmann type in the acceleration variable is solved numerically for a special driver interaction model. The solution is done by a modified direct simulation Monte Carlo method (DSMC) well known in non equilibrium gas kinetic. The velocity and acceleration distribution functions in stochastic equilibrium, mean velocity, traffic density, ACN, velocity scattering and correlations between some of these variables and their car density dependences are discussed.Comment: 23 pages, 10 figure

High-resolution stratigraphy of the Newark rift basin (early Mesozoic, eastern North America)

Virtually the entire Late Triassic and earliest Jurassic age section of the early Mesozoic Newark continental rift basin has been recovered in over 6770 m of continuous core as part of the Newark Basin Coring Project (NBCP). Core was collected using an offset drilling method at seven sites in the central part of the basin. The cores span most of the fluvial Stockton Formation, all of the lacustrine Lockatong and Passaic formations, the Orange Mountain Basalt, and nearly all of the lacustrine Feltville Formation. The cores allow for the first time the full Triassic-age part of the Newark basin stratigraphic sequence to be described in detail. This includes the gray, purple, and red, mostly fluvial Stockton Formation as well as the 53 members that make up the lacustrine Lockatong (mostly gray and black) and Passaic (mostly red) formations. The nearly 25% overlap zones between each of the stratigraphically adjacent cores are used to test lateral correlations in detail, scale the cores to one another, and combine them in a 4660-m-thick composite section. This composite shows that the entire post-Stockton sedimentary section consists of a hierarchy of sedimentary cycles, thought to be of Milankovitch climate cycle origin. Lithostratigraphic and magnetostratigraphic correlations between core overlap zones and outcrops demonstrate that the individual sedimentary cycles can be traced essentially basinwide. The agreement between the cyclostratigraphy and magnetostratigraphy shows both the cycles and the polarity boundaries to be isochronous horizons. Detailed analysis of the Newark basin shows that high-resolution cyclostratigraphy is possible in lacustrine, primarily red-bed rift sequences and provides a fine-scale framework for global correlations and an understanding of continental tropical climate change

Subtractive gene expression profiling of articular cartilage and mesenchymal stem cells: serpins as cartilage-relevant differentiation markers

SummaryObjectiveMesenchymal stem cells (MSCs) are a population of cells broadly discussed to support cartilage repair. The differentiation of MSCs into articular chondrocytes is, however, still poorly understood on the molecular level. The aim of this study was to perform an almost genome-wide screen for genes differentially expressed between cartilage and MSCs and to extract new markers useful to define chondrocyte differentiation stages.MethodsGene expression profiles of MSCs (n=8) and articular cartilage from OA patients (n=7) were compared on a 30,000 cDNA-fragment array and differentially expressed genes were extracted by subtraction. Expression of selected genes was assessed during in vitro chondrogenic differentiation of MSCs and during dedifferentiation of expanded chondrocytes using quantitative and semi-quantitative reverse transcriptase-polymerase chain reaction (RT-PCR). Protein secretion was measured by enzyme-linked immunosorbent assay.ResultsEighty-seven genes were differentially expressed between MSCs and cartilage with a more than three-fold difference. Sixty-seven of them were higher expressed in cartilage and among them 15 genes were previously not detected in cartilage. Differential expression was confirmed for 69% of 26 reanalysed genes by RT-PCR. The profiles of three unknown transcripts and six protease-related molecules were characterised during differentiation. SERPINA1 and SERPINA3 mRNA expression correlated with chondrogenic differentiation of MSCs and dedifferentiation of chondrocytes, and SERPINA1 protein levels in culture supernatants could be correlated alike.ConclusionscDNA-array analysis identified SERPINA1 and A3 as new differentiation-relevant genes for cartilage. Since SERPINA1 secretion correlated with both chondrogenesis of MSCs and dedifferentiation during chondrocyte expansion, it represents an attractive marker for refinement of chondrocyte differentiation

Sustained correction of B-cell development and function in a murine model of X-linked agammaglobulinemia (XLA) using retroviral-mediated gene transfer

X-linked agammaglobulinemia (XLA) is a human immunodeficiency caused by mutations in Bruton tyrosine kinase (Btk) and characterized by an arrest in early B-cell development, near absence of serum immunoglobulin, and recurrent bacteria infections. Using Btk- and Tec-deficient mice (BtkTec-/-) as a model for XLA, we determined if Btk gene therapy could correct this disorder. Bone marrow (BM) from 5-fluorouracil (5FU)-treated BtkTec-/- mice was transduced with a retroviral vector expressing human Btk and transplanted into BtkTec-/- recipients. Mice engrafted with transduced hematopoietic cells exhibited rescue of both primary and peripheral B-lineage development, revocery of peritoneal B1 B cells, and correction of serum immunoglobulin M (IgM) and IgG3 levels. Gene transfer also restored T-independent type II immune responses, and B-cell antigen receptor (BCR) proliferative responses. B-cell progenitors derived from Btk-transduced stem cells exhibited higher levels of Btk expression than non-B cells; and marking studies demonstrated a selective advantage for Btk-transduced B-lineage cells. BM derived from primary recipients also rescued Btk-dependent function in secondary hosts that had received a transplant. Together, these data demonstrate that gene transfer into hematopoietic stem cells can reconstitute Btk-dependent B-cell development and function in vivo, and strongly support the feasibility of pursuing Btk gene transfer for XLA