Recovery index, attentiveness and state of memory after xenon or isoflurane anaesthesia: a randomized controlled trial

<p>Abstract</p> <p>Background</p> <p>Performance of patients immediately after anaesthesia is an area of special interest and so a clinical trial was conducted to compare Xenon with Isoflurane anaesthesia. In order to assess the early cognitive recovery the syndrome short test (SST) according to Erzigkeit (Geromed GmbH) was applied.</p> <p>Methods</p> <p>ASA I and II patients undergoing long and short surgical interventions were randomised to receive either general anaesthesia with Xenon or Isoflurane. The primary endpoint was the validated SST which covering memory disturbances and attentiveness. The test was used on the day prior to intervention, one and three hours post extubation. The secondary endpoint was the recovery index (RI) measured after the end of the inhalation of Xenon or Isoflurane. In addition the Aldrete score was evaluated up to 180 min. On the first post-operative day the patients rated the quality of the anaesthetic using a scoring system from 1-6.</p> <p>Results</p> <p>The demographics of the groups were similar. The sum score of the SST delivered a clear trend one hour post extubation and a statistically significant superiority for Xenon three hours post extubation (p < 0.01). The RI likewise revealed a statistically significant superiority of Xenon 5 minutes post extubation (p < 0.01). The Aldrete score was significantly higher for 45 min. The scoring system results were also better after Xenon anaesthesia (p < 0.001).</p> <p>Conclusions</p> <p>The results show that recovery from anaesthesia and the early return of post-operative cognitive functions are significantly better after Xenon anaesthesia compared to Isoflurane. The results of the RI for Xenon are similar with the previously published results.</p> <p>Trial Registration</p> <p>The trial was registered with the number ISRCTN01110844 <url>http://www.controlled-trials.com/isrctn/pf/01110844</url>.</p

Reaction Rates

Manthe U. Reaction Rates. In: W. J, ed. Lecture notes in Chemistry, Vol. 77: Methods in Reaction Dynamics. Berlin/Heidelberg: Springer-Verlag; 2001: 167

EXACT QUANTUM AND SEMICLASSICAL CALCULATION OF POSITIONS AND RESIDUES OF REGGE-POLES FOR INTERATOMIC POTENTIALS

Semiclassical and exact quantum methods have been used to calculate the positions and residues of Regge poles for two interatomic potentials. A Lennard-Jones (6,4) potential with parameters approximating H+-Ar collisions and a Lennard-Jones (12,6) potential with parameters approximating the elastic scattering of K by HBr have been used. There is good agreement between the semiclassical and quantum calculations both for the pole positions and modulus and phase of the residues. Some properties of Regge trajectories for the Lennard-Jones (12,6) potential are also investigated

PROPERTIES OF REGGE-POLE POSITIONS AND RESIDUES FOR INTER-ATOMIC POTENTIALS

A detailed investigation of the Regge properties of singular intermolecular potentials has been made. Inverse power potentials of the type r-s with s&gt;2 and Lennard-Jones (12, 6) potentials are considered. Exact quantum and semiclassical calculations are carried out for collision systems for which the residue of maximum modulus is of order unity. Good agreement between the exact quantum and semiclassical results is found. The existence of non-linear as well as linear Regge trajectories is established. The accuracy and utility of some simple approximate formulae due to Brander (1966) and Tiktopoulos (1969) for the Regge properties of r-s potentials is investigated. A new approximate formula based on a complex harmonic oscillator formalism is also derived. It is shown that these approximate formulae can be used to understand the main Regge properties of singular intermolecular potentials