Search for Rare b-hadron Decays at CDF

We report on searches for B^0_s to \mu^+ \mu^-, B^0_d to \mu^+ \mu^- decays and b to s \mu^+\mu^- transitions in exclusive decays of B mesons. Using 2 fb^{-1} of data collected by the CDF II detector we find upper limits on the branching fractions B(B^0_s to \mu^+ \mu^-) < 5.8 x 10^{-8} and B(B^0_d to \mu^+ \mu^-) < 1.8 x 10^{-8} at 95% confidence level. Using 924 pb^{-1} of data we measure the branching fractions B(B^+ to \mu^+ \mu^- K^+) = (0.60 \pm 0.15 \pm 0.04) x 10^{-6}, B(B^0_d to \mu^+ \mu^- K^{*0}) = (0.82 \pm 0.31 \pm 0.10) x 10^{-6} and the limit B(B^0_s to \mu^+ \mu^- phi)/B(B^0_s to J/\psi\phi) < 2.61(2.30) x 10^{-3} at 95(90)% confidence level.Comment: 3 pages, 5 figures, conference proceedings to the 2007 Europhysics Conference on High Energy Physics (Manchester, July 2007

Radiative penguin Bs decays at Belle

We report searches for the radiative penguin decays Bs to phi gamma and Bs to gamma gamma based on a 23.6 fb-1 data sample collected with the Belle detector at the KEKB e+e- energy-asymmetric collider operating at the Upsilon(5S) resonance.Comment: On behalf of the Belle Collaboration. To appear in the proceedings of the International Europhysics Conference on High Energy Physics (EPS-HEP2007), Manchester, England, 19-25 July 2007. 3 pages, 2 figure

New parametrization for the nuclear covariant energy density functional with point-coupling interaction

A new parametrization PC-PK1 for the nuclear covariant energy density functional with nonlinear point-coupling interaction is proposed by fitting to observables for 60 selected spherical nuclei, including the binding energies, charge radii and empirical pairing gaps. The success of PC-PK1 is illustrated in its description for infinite nuclear matter and finite nuclei including the ground-state and low-lying excited states. Particularly, PC-PK1 improves the description for isospin dependence of binding energy along either the isotopic or the isotonic chains, which makes it more reliable for application in exotic nuclei. The predictive power of PC-PK1 is also illustrated for the nuclear low-lying excitation states in a five-dimensional collective Hamiltonian in which the parameters are determined by constrained calculations for triaxial shapes.Comment: 32 pages, 12 figures, 4 tables, accepted by Phys. Rev.

Model-independent analysis for determining mass splittings of heavy baryons

We study the hyperfine mass differences of heavy hadrons in the heavy quark effect theory (HQET). The effects of one-gluon exchange interaction are considered for the heavy mesons and baryons. Base on the known experimental data, we predict the masses of some heavy baryons in a model-independent way.Comment: 14 pages, 1 figur

Effect of pairing correlations on nuclear low-energy structure: BCS and general Bogoliubov transformation

Low-lying nuclear states of Sm isotopes are studied in the framework of a collective Hamiltonian based on covariant energy density functional theory. Pairing correlation are treated by both BCS and Bogoliubov methods. It is found that the pairing correlations deduced from relativistic Hartree-Bogoliubov (RHB) calculations are generally stronger than those by relativistic mean-field plus BCS (RMF+BCS) with same pairing force. By simply renormalizing the pairing strength, the diagonal part of the pairing field is changed in such a way that the essential effects of the off-diagonal parts of the pairing field neglected in the RMF+BCS calculations can be recovered, and consequently the low-energy structure is in a good agreement with the predictions of the RHB model.Comment: 5 figures, 5 page

Numerical simulation of solid tumor blood perfusion and drug delivery during the “vascular normalization window” with antiangiogenic therapy

This Article is provided by the Brunel Open Access Publishing Fund - Copyright @ 2011 Hindawi PublishingTo investigate the influence of vascular normalization on solid tumor blood perfusion and drug delivery, we used the generated blood vessel network for simulations. Considering the hemodynamic parameters changing after antiangiogenic therapies, the results show that the interstitial fluid pressure (IFP) in tumor tissue domain decreases while the pressure gradient increases during the normalization window. The decreased IFP results in more efficient delivery of conventional drugs to the targeted cancer cells. The outcome of therapies will improve if the antiangiogenic therapies and conventional therapies are carefully scheduled

Local anaesthetic bupivacaine induced ovarian and prostate cancer apoptotic cell death and underlying mechanisms in vitro

Retrospective studies indicate that the use of regional anesthesia can reduce cancer recurrence after surgery which could be due to ranging from immune function preservation to direct molecular mechanisms. This study was to investigate the effects of bupivacaine on ovarian and prostate cancer cell biology and the underlying molecular mechanisms. Cell viability, proliferation and migration of ovarian carcinoma (SKOV-3) and prostate carcinoma (PC-3) were examined following treatment with bupivacaine. Cleaved caspase 3, 8 and 9, and GSK-3β, pGSK-3β(tyr216) and pGSK-3β(ser9) expression were assessed by immunofluorescence. FAS ligand neutralization, caspase and GSK-3 inhibitors and GSK-3β siRNA were applied to further explore underlying mechanisms. Clinically relevant concentrations of bupivacaine reduced cell viability and inhibited cellular proliferation and migration in both cell lines. Caspase 8 and 9 inhibition generated partial cell death reversal in SKOV-3, whilst only caspase 9 was effective in PC-3. Bupivacaine increased the phosphorylation of GSK-3β(Tyr216) in SKOV-3 but without measurable effect in PC3. GSK-3β inhibition and siRNA gene knockdown decreased bupivacaine induced cell death in SKOV-3 but not in PC3. Our data suggests that bupivacaine has direct ‘anti-cancer’ properties through the activation of intrinsic and extrinsic apoptotic pathways in ovarian cancer but only the intrinsic pathway in prostate cancer