1,917 research outputs found
High quality ultrafast transmission electron microscopy using resonant microwave cavities
Ultrashort, low-emittance electron pulses can be created at a high repetition
rate by using a TM deflection cavity to sweep a continuous beam across
an aperture. These pulses can be used for time-resolved electron microscopy
with atomic spatial and temporal resolution at relatively large average
currents. In order to demonstrate this, a cavity has been inserted in a
transmission electron microscope, and picosecond pulses have been created. No
significant increase of either emittance or energy spread has been measured for
these pulses.
At a peak current of pA, the root-mean-square transverse normalized
emittance of the electron pulses is m rad in the direction parallel to the streak of the cavity, and
m rad in the perpendicular
direction for pulses with a pulse length of 1.1-1.3 ps. Under the same
conditions, the emittance of the continuous beam is
m rad.
Furthermore, for both the pulsed and the continuous beam a full width at half
maximum energy spread of eV has been measured
Theory and particle tracking simulations of a resonant radiofrequency deflection cavity in TM mode for ultrafast electron microscopy
We present a theoretical description of resonant radiofrequency (RF)
deflecting cavities in TM mode as dynamic optical elements for
ultrafast electron microscopy. We first derive the optical transfer matrix of
an ideal pillbox cavity and use a Courant-Snyder formalism to calculate the 6D
phase space propagation of a Gaussian electron distribution through the cavity.
We derive closed, analytic expressions for the increase in transverse emittance
and energy spread of the electron distribution. We demonstrate that for the
special case of a beam focused in the center of the cavity, the low emittance
and low energy spread of a high quality beam can be maintained, which allows
high-repetition rate, ultrafast electron microscopy with 100 fs temporal
resolution combined with the atomic resolution of a high-end TEM. This is
confirmed by charged particle tracking simulations using a realistic cavity
geometry, including fringe fields at the cavity entrance and exit apertures
Design and characterization of dielectric filled TM microwave cavities for ultrafast electron microscopy
Microwave cavities oscillating in the TM mode can be used as dynamic
electron-optical elements inside an electron microscope. By filling the cavity
with a dielectric material it becomes more compact and power efficient,
facilitating the implementation in an electron microscope. However, the
incorporation of the dielectric material makes the manufacturing process more
difficult. Presented here are the steps taken to characterize the dielectric
material, and to reproducibly fabricate dielectric filled cavities. Also
presented are two versions with improved capabilities. The first, called a
dual-mode cavity, is designed to support two modes simultaneously. The second
has been optimized for low power consumption. With this optimized cavity a
magnetic field strength of 2.84 0.07 mT was generated at an input power
of 14.2 0.2 W. Due to the low input powers and small dimensions, these
dielectric cavities are ideal as electron-optical elements for electron
microscopy setups
Feasibility of a Pulsed Ponderomotive Phase Plate for Electron Beams
We propose a scheme for constructing a phase plate for use in an ultrafast
Zernike-type phase contrast electron microscope, based on the interaction of
the electron beam with a strongly focused, high-power femtosecond laser pulse
and a pulsed electron beam. Analytical expressions for the phase shift using
the time-averaged ponderomotive potential and a paraxial approximation for the
focused laser beam are presented, as well as more rigorous quasiclassical
simulations based on the quantum phase integral along classical, relativistic
electron trajectories in an accurate, non-paraxial description of the laser
beam. The results are shown to agree well unless the laser beam is focused to a
waist size below a wavelength. For realistic (off-the-shelf) laser parameters
the optimum phase shift of is shown to be achievable. When combined
with RF-cavity based electron chopping and compression techniques to produce
electron pulses, a femtosecond regime pulsed phase contrast microscope can be
constructed. The feasibility and robustness of the scheme are further
investigated using the simulations, leading to motivated choices for design
parameters such as wavelength, focus size and polarization.Comment: 16 pages, 6 figure
Dual mode microwave deflection cavities for ultrafast electron microscopy
This paper presents the experimental realization of an ultrafast electron
microscope operating at a repetition rate of 75 MHz based on a single compact
resonant microwave cavity operating in dual mode. This elliptical cavity
supports two orthogonal TM modes with different resonance frequencies
that are driven independently. The microwave signals used to drive the two
cavity modes are generated from higher harmonics of the same Ti:Sapphire laser
oscillator. Therefore the modes are accurately phase-locked, resulting in
periodic transverse deflection of electrons described by a Lissajous pattern.
By sending the periodically deflected beam through an aperture, ultrashort
electron pulses are created at a repetition rate of 75 MHz. Electron pulses
with fs pulse duration are created with only W
of microwave input power; with normalized rms emittances of
pm rad and pm rad for
a peak current of nA. This corresponds to an rms normalized
peak brightness of A/m sr V, equal
to previous measurements for the continuous beam. In addition, the FWHM energy
spread of eV is also unaffected by the dual mode
cavity. This allows for ultrafast pump-probe experiments at the same spatial
resolution of the original TEM in which a 75 MHz Ti:Sapphire oscillator can be
used for exciting the sample. Moreover, the dual mode cavity can be used as a
streak camera or time-of-flight EELS detector with a dynamic range
Increasing survival gap between young and elderly gastric cancer patients
INTRODUCTION: This study investigates the treatment and survival of young versus elderly potentially curable gastric cancer patients in the Netherlands. PATIENTS AND METHODS: All noncardia gastric cancer patients with potentially curable gastric cancer according to stage (cTx-3, cNx-3, and cMx-0) diagnosed between 1989 and 2013 were selected from the Netherlands Cancer Registry. Trends in treatment and overall survival were compared between young patients (younger than 70 years) and elderly patients (70 years or older). Multivariable logistic regression analysis was used to examine the probability of patients undergoing surgery and chemotherapy in the most recent period. Multivariable Cox regression analysis was used to identify independent factors associated with survival. RESULTS: In total, 8107 young and 13,814 elderly gastric cancer patients were included. There was a major increase in the proportion of patients treated with resection and chemotherapy after 2004-2008. In young patients the increase was from 2.6% in 1999-2003 to 63% in 2009-2013 (p < 0.01). Also an increase was noticed among elderly patients, from 0.1% to 16% (p < 0.01). Median survival increased from 2004 to 2008 onward particularly in young patients and to a lesser extent in elderly patients (from 28 to 41 months vs from 11 to 13 months). Multivariable Cox regression analyses confirmed that overall survival improved for young and elderly patients. DISCUSSION: Young patients experienced a stronger improvement in survival than elderly patients, resulting in an increasing survival gap. The literature shows this is a problem not only in the Netherlands but also throughout Europe. The dissimilarity in treatment between young and elderly patients could be the reason for this difference
Clinical and Physiological Correlates of Irritability in Depression: Results from the Netherlands Study of Depression and Anxiety
Objective. Irritable and nonirritable depressed patients differ on demographic and clinical characteristics. We investigated whether this extends to psychological and physiological measures. Method. We compared irritable and nonirritable unipolar depressed patients on symptomatology, personality, and (psycho)physiological measures (cortisol, cholesterol, and heart rate variability). Symptomatology was reassessed after one year, and we also compared depressed patients who were irritable or non-irritable at both time points (Irr++ versus
Irr−−). Results. Almost half (46%; N = 420) of the sample was classified as irritable. These patients scored higher on depression severity, anxiety, hypomanic symptoms, and psychological variables. No differences were observed on physiological markers after correction for depression severity. The same pattern was found when comparing Irr++ and Irr−− groups. Conclusion. Irritable and non-irritable depressed patients differ on clinical and psychological variables, but not on the currently investigated physiological markers. The clinical relevance of the distinction and the significance of the hypomanic symptoms remain to be demonstrated
Construction of Special Solutions for Nonintegrable Systems
The Painleve test is very useful to construct not only the Laurent series
solutions of systems of nonlinear ordinary differential equations but also the
elliptic and trigonometric ones. The standard methods for constructing the
elliptic solutions consist of two independent steps: transformation of a
nonlinear polynomial differential equation into a nonlinear algebraic system
and a search for solutions of the obtained system. It has been demonstrated by
the example of the generalized Henon-Heiles system that the use of the Laurent
series solutions of the initial differential equation assists to solve the
obtained algebraic system. This procedure has been automatized and generalized
on some type of multivalued solutions. To find solutions of the initial
differential equation in the form of the Laurent or Puiseux series we use the
Painleve test. This test can also assist to solve the inverse problem: to find
the form of a polynomial potential, which corresponds to the required type of
solutions. We consider the five-dimensional gravitational model with a scalar
field to demonstrate this.Comment: LaTeX, 14 pages, the paper has been published in the Journal of
Nonlinear Mathematical Physics (http://www.sm.luth.se/math/JNMP/
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