6 research outputs found
Chromosome-centric Human Proteome Project (C-HPP): Chromosome 12
Following an official announcement of the Chromosome-centric Human Proteome Project (C-HPP), the Chromosome 12 (Ch12) Consortium has been established by five representative teams from five Asian countries including Thailand (Siriraj Hospital, Mahidol University), Singapore (National University of Singapore), Taiwan (Academia Sinica), Hong Kong (The Chinese University of Hong Kong), and India (Institute of Bioinformatics). We have worked closely together to extensively and systematically analyze all missing and known proteins encoded by Ch12 for their tissue/cellular/subcellular localizations. The target organs/tissues/cells include kidney, brain, gastrointestinal tissues, blood/immune cells, and stem cells. In the later phase, post-translational modifications and functional significance of Ch12-encoded proteins as well as their associations with human diseases (i.e., immune diseases, metabolic disorders, and cancers) will be defined. We have collaborated with other chromosome teams, Human Kidney and Urine Proteome Project (HKUPP), AOHUPO Membrane Proteomics Initiative, and other existing HUPO initiatives in the Biology/Disease-Based Human Proteome Project (B/D-HPP) to delineate functional roles and medical implications of Ch12-encoded proteins. The data set to be obtained from this multicountry consortium will be an important piece of the jigsaw puzzle to fulfill the missions and goals of the C-HPP and the global Human Proteome Project (HPP)
Chromosome-centric Human Proteome Project (C-HPP): Chromosome 12
Following an official announcement
of the Chromosome-centric Human
Proteome Project (C-HPP), the Chromosome 12 (Ch12) Consortium has
been established by five representative teams from five Asian countries
including Thailand (Siriraj Hospital, Mahidol University), Singapore
(National University of Singapore), Taiwan (Academia Sinica), Hong
Kong (The Chinese University of Hong Kong), and India (Institute of
Bioinformatics). We have worked closely together to extensively and
systematically analyze all missing and known proteins encoded by Ch12
for their tissue/cellular/subcellular localizations. The target organs/tissues/cells
include kidney, brain, gastrointestinal tissues, blood/immune cells,
and stem cells. In the later phase, post-translational modifications
and functional significance of Ch12-encoded proteins as well as their
associations with human diseases (i.e., immune diseases, metabolic
disorders, and cancers) will be defined. We have collaborated with
other chromosome teams, Human Kidney and Urine Proteome Project (HKUPP),
AOHUPO Membrane Proteomics Initiative, and other existing HUPO initiatives
in the Biology/Disease-Based Human Proteome Project (B/D-HPP) to delineate
functional roles and medical implications of Ch12-encoded proteins.
The data set to be obtained from this multicountry consortium will
be an important piece of the jigsaw puzzle to fulfill the missions
and goals of the C-HPP and the global Human Proteome Project (HPP)